Looking for 126544-47-6 / Ciclesonide API manufacturers, exporters & distributors?
Ciclesonide manufacturers, exporters & distributors
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API | Excipient name
Ciclesonide
Synonyms
Alvesco, Omnaris, 126544-47-6, Zetonna, Rpr251526, Rpr-251526
Unique Ingredient Identifier (UNII)
S59502J185
About Ciclesonide
Ciclesonide is a nonhalogenated, synthetic, inhaled corticosteroid (ICS) with anti-inflammatory and potential antiviral activities. Upon administration by oral inhalation into the lungs, ciclesonide (CIC) is converted by local esterases to its active metabolite desisobutyryl-ciclesonide (des-CIC), which binds to intracellular glucocorticoid receptors (GRs). The ligand-bound GRs regulate gene expressions, which lead to inhibitory activities against multiple cell types, such as mast cells, eosinophils, basophils, lymphocytes, macrophages and neutrophils, and various mediators associated with inflammation, such as histamine, eicosanoids, leukotrienes and cytokines. In addition, ciclesonide may suppress the replication of human coronavirus by targeting viral nonstructural protein 15 (NSP15).