Looking for 149845-07-8 / Tiludronic Acid API manufacturers, exporters & distributors?
Tiludronic Acid manufacturers, exporters & distributors
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API | Excipient name
Tiludronic Acid
Synonyms
149845-07-8, Tiludronic acid disodium salt, Skelid, Disodium tiludronate, Sr 41319b, Tiludronate disodium [usan]
Unique Ingredient Identifier (UNII)
BH6M93CIA0
About Tiludronic Acid
Tiludronate Disodium is the disodium salt form of tiludronate, a first-generation, non-nitrogenous bisphosphonate analogue of endogenous pyrophosphate. Tiludronate adsorbs to hydroxyapatite cells, and although the exact mechanism through which this bisphosphonate exerts its effect has yet to be fully elucidated, tiludronate appears to inhibit protein-tyrosine-phosphatase (PTP) in osteoclasts, thereby disrupting the cytoskeletal ring structure and suppressing the bone resorbing activity of osteoclasts. In addition, tiludronate appears to inhibit the vacuolar-type proton ATPase (V-ATPase) in osteoclasts. Altogether, this may reduce the number of osteoclasts, inhibit abnormal bone resorption and reduce bone turnover.
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For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.