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    List of USP reference standards related to Carboxylic Acid

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    Carboxylic Acid

    APIs // Active Pharmaceutical Ingredients

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    REF. STANDARDS & IMPURITIES

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    01 Adapalene Related Compound E (25 mg) (2,2'-binaphthyl-6,6'-dicarboxylic acid) (1)

    02 Amoxicillin Related Compound A (15 mg) ((2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid) (1)

    03 Amoxicillin Related Compound G (15 mg) ((2S,5R,6R)-6-{(R)-2-[(R)-2-Amino-2-(4-hydroxyphenyl)acetamido]-2-(4-hydroxyphenyl)acetamido}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid) (1)

    04 Argatroban Related Compound A (15 mg) ((2R,4R)-1-[N8-nitro- N2-(3-methylquinoline-8-sulfonyl)-L-arginyl]-4-methylpiperidine-2-carboxylic acid) (1)

    05 Argatroban Related Compound C (20 mg) ((2R,4R)-1-[N^8-amino- N^2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonyl)-L-arginyl]-4-methylpiperidine-2-carboxylic acid) (1)

    06 Articaine Related Compound B (25 mg) (4-methyl-3-{[2-(propylamino)propanoyl]amino}thiophene-2-carboxylic acid) (1)

    07 Atorvastatin Related Compound D (10 mg) (Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2-carboxylic acid phenylamide) (1)

    08 Cefadroxil Related Compound B (25 mg) ((6R,7R)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid) (1)

    09 Cefadroxil Related Compound D (25 mg) ((6R,7R)-7-[(S)-2-Amino-2-(4-hydroxyphenyl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid) (1)

    10 Cefadroxil Related Compound I (25 mg) ((6R,7R)-7-[(R)-2-amino-2-(4-hydroxyphenyl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid) (1)

    11 Cefdinir Related Compound B (10 mg) ((6R,7R)-7-[2-(2-amino-4-thiazolyl)acetamido]-8-oxo-3-vinyl-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid) (1)

    12 Cefprozil L-Epimer (30 mg) ((6R,7R)-7-[(S)-2-amino-2-(4-hydroxyphenyl)acetamido]-8-oxo-3-[(Z)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid) (1)

    13 Cefprozil Related Compound D (30 mg) ((6R,7R)-7-amino-8-oxo-3-[(Z)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid) (1)

    14 Cefprozil Related Compound H (30 mg) ((6R,7R)-7-{(R)-2-[(R)-2-amino-2-(4-hydroxyphenyl)acetamido]-2-(4-hydroxyphenyl)acetamido}-8-oxo-3-[(Z)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid) (1)

    15 Cephalexin Related Compound F (25 mg) ((6R,7R)-7-[(R)-2-Amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid, dihydrate) (1)

    16 Chlorthalidone Related Compound A (10 mg) (4'-Chloro-3'-sulfamoyl-2-benzophenone Carboxylic Acid) (1)

    17 Ciprofloxacin Ethylenediamine Analog (25 mg) (1-Cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-[(2-aminoethyl)-amino]-3-quinolinecarboxylic acid hydrochloride) (1)

    18 Ciprofloxacin Related Compound A (25 mg) (7-Chloro-1-cyclopropyl-4-oxo-6-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride salt) (AS) (1)

    19 Cloxacillin Related Compound D (15 mg) (3-(2-Chlorophenyl)-5-methylisoxazole-4-carboxylic acid) (1)

    20 Color Related Compound 005 (20 mg) (3-hydroxy-2-naphthalenecarboxylic acid) (1)

    21 Cyclohexanecarboxylic Acid (500 mg) (1)

    22 Dicloxacillin Related Compound D (15 mg) (3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carboxylic acid) (1)

    23 Diphenoxylate Related Compound A CI (25 mg) (1-(3-Cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid) (1)

    24 Doxazosin Related Compound D (20 mg) (1,4-benzodioxane-2-carboxylic acid) (1)

    25 Drospirenone Related Compound A (15 mg) (17-Hydroxy-6beta,7beta:15beta,16beta-dimethylene-3-oxo-17beta-pregn-4-ene-21-carboxylic acid, gamma-lactone) (1)

    26 Flavoxate Related Compound A (25 mg) (3-methylflavone-8-carboxylic acid) (1)

    27 Flavoxate Related Compound B (20 mg) (3-Methylflavone-8-carboxylic acid methyl ester) (1)

    28 Flavoxate Related Compound C (20 mg) (3-Methylflavone-8-carboxylic acid ethyl ester) (1)

    29 Flumazenil Related Compound A (20 mg) (8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazol-[1,5-alpha][1,4]benzodiazepine-3-carboxylic acid) (1)

    30 Gabapentin Related Compound E (25 mg) (carboxymethyl-cyclohexanecarboxylic acid) (1)

    31 Glycopyrrolate Related Compound A (50 mg) (5-Nitrobenzene-1,3-dicarboxylic acid) (1)

    32 Granisetron Related Compound D (15 mg) (1-methyl-1H-indazole-3-carboxylic acid) (1)

    33 Irbesartan Related Compound A (25 mg) (1-pentanoylamino-cyclopentanecarboxylic acid [2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-amide) (1)

    34 Lamivudine Related Compound A (25 mg) ((2RS,5R)-5-(Cytosine-1-yl)-1,3-oxathiolane-2-carboxylic acid) (1)

    35 Levocabastine Related Compound A (50 mg) (1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-4-phenylpiperidine-4-carboxylic acid hydrochloride) (1)

    36 Levofloxacin Related Compound A (25 mg) ((S)-9-fluoro-3-methyl-10-(piperazin-1-yl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid) (1)

    37 Levofloxacin Related Compound B (35 mg) ((S)-9,10,difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid) (1)

    38 Levofloxacin Related Compound E (25 mg) ((S)-9-Fluoro-2,3-dihydro-3-methyl-10-[2-(methylamino)ethylamino]-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hydrochloride) (1)

    39 Levofloxacin Related Compound F (25 mg) ((S)-2,3-Dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid) (1)

    40 Lorazepam Related Compound D (25 mg) (6-Chloro-4-(o-chlorophenyl)-2-quinazolinecarboxylic Acid) (1)

    41 Moexipril Related Compound A (20 mg) ((3S)-2-{(2S)-N-[(1S)-1-Carboxy-3-phenylpropyl]alanyl}-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid) (1)

    42 Moxifloxacin Related Compound A (25 mg) (1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid) (1)

    43 Moxifloxacin Related Compound B (25 mg) (1-Cyclopropyl-6,8-dimethoxy-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride monohydrate) (1)

    44 Moxifloxacin Related Compound C (25 mg) (1-Cyclopropyl-8-ethoxy-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride monohydrate) (1)

    45 Moxifloxacin Related Compound D (15 mg) (1-Cyclopropyl-8-fluoro-6-methoxy-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid) (1)

    46 Moxifloxacin Related Compound E (25 mg) (1-Cyclopropyl-6-fluoro-8-hydroxy-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride) (1)

    47 Nateglinide Related Compound A (10 mg) (trans-4-isopropylcyclohexanecarboxylic acid) (1)

    48 Norfloxacin Related Compound A (15 mg) (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid) (1)

    49 Norfloxacin Related Compound E (15 mg) (7-Chloro-1-ethyl-4-oxo-6-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid) (1)

    50 Norfloxacin Related Compound H (15 mg) (7-[4-(ethoxycarbonyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid) (1)

    51 Norfloxacin Related Compound K (15 mg) (6-Fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid) (1)

    52 Ofloxacin Related Compound A (25 mg) (9-Fluoro-3-methyl-7-oxo-10-(piperazin-1-yl)-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid) (1)

    53 Oxacillin Related Compound C (15 mg) (5-Methyl-3-phenylisoxazole-4-carboxylic acid) (1)

    54 Perindopril Related Compound A (20 mg) ((2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid) (1)

    55 Perindopril Related Compound B (10 mg) ((2S,3aS,7aS)-1-{(S)-2-[(S)-1-carboxybutylamino]propanoyl}octahydro-1H-indole-2-carboxylic acid) (1)

    56 Perindopril Related Compound E (10 mg) ((2S,3aS,7aS)-1-{(S)-2-[(S)-1-isopropoxy-1-oxopentan-2-ylamino]propanoyl}octahydro-1H-indole-2-carboxylic acid, tert-butylamine) (1)

    57 Quinapril Related Compound B (50 mg) (3-Isoquinolinecarboxylic acid, 2-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-1,2,3,4-tetrahydro-,[3S-[2[R*(R*)],3R*]]-) (1)

    58 R-Ofloxacin (25 mg) ((R)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid) (1)

    59 Ramipril Related Compound A (30 mg) ((2S,3aS,6aS)-1-[(S)2-[[(S)-1-(methoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid) (1)

    60 Ribavirin Related Compound A (15 mg) (1-beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxylic acid) (1)

    61 Ropivacaine Related Compound B (50 mg) ((R)-(+)-1-Propylpiperidine-2-carboxylic acid (2,6-dimethylphenyl)-amide hydrochloride monohydrate) (1)

    62 Sennoside A (20 mg) ((9R,9'R)-5,5'-Bis(beta-d-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9',10,10'-tetrahydro-9,9'-bianthracene-2,2'-dicarboxylic acid) (1)

    63 Sulbactam Related Compound E (15 mg) ((2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide) (1)

    64 Sulbactam Related Compound F (15 mg) ((2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid) (1)

    65 Telmisartan Related Compound B (15 mg) (4'-[(1,7'-dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazol-1'-yl)methyl]biphenyl-2-carboxylic acid) (1)

    66 Trandolapril Related Compound A (25 mg) ((2S,3aR,7aS)-1-[N-[(S)-1-carboxy-3-phenylpropyl]-L-alanyl]hexahydro-2-indolinecarboxylic acid 1-methyl ester) (1)

    67 Trandolapril Related Compound C (25 mg) ((2S, 3aR, 7aS)-1-[N-[(S)-1-Carboxy-3-cyclohexylpropyl]-L-alanyl]hexahydro-2-indolinecarboxylic acid 1-ethyl ester hydrochloride) (1)

    68 Trandolapril Related Compound E (25 mg) ((2S,3aR,7aS)-1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]hexahydro-2-indolinecarboxylic acid) (1)

    69 Tranexamic Acid Related Compound C (15 mg) ((RS)-4-(aminomethyl)cyclohex-1-enecarboxylic acid) (1)

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      Perindopril Related Compound E (10 mg) ((2S,3aS,7aS)-1-...

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      F0L122
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        Perindopril Related Compound B (10 mg) ((2S,3aS,7aS)-1-...

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        1510903
        95153-31-4
        F0L113
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          Perindopril Related Compound A (20 mg) ((2S,3aS,7aS)-oc...

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          1510890
          80875-98-5
          F0L105 (30-JUN-2018)
          850
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            Oxacillin Related Compound C (15 mg) (5-Methyl-3-phenyl...

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            1481044
            1136-45-4
            F01790
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              Ofloxacin Related Compound A (25 mg) (9-Fluoro-3-methyl...

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              1478119
              82419-52-1
              R039Q0
              G0K034 (30-APR-2017)
              805
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                R-Ofloxacin (25 mg) ((R)-9-fluoro-2,3-dihydro-3-methyl-...

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                100986-86-5
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                  Norfloxacin Related Compound K (15 mg) (6-Fluoro-1-meth...

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                  1471619
                  70459-07-3
                  F000G0
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                    Norfloxacin Related Compound H (15 mg) (7-[4-(ethoxycar...

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                    105440-01-5
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                      Norfloxacin Related Compound E (15 mg) (7-Chloro-1-ethy...

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                      1471550
                      75001-78-4
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                        Norfloxacin Related Compound A (15 mg) (7-Chloro-1-ethy...

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                        1471517
                        68077-26-9
                        F000D0
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