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Also known as: 81110-73-8, Acetorphan, Benzyl 2-(3-(acetylthio)-2-benzylpropanamido)acetate, Hidrasec, Tiorfan, Racecadotril [inn]
Molecular Formula
C21H23NO4S
Molecular Weight
385.5  g/mol
InChI Key
ODUOJXZPIYUATO-UHFFFAOYSA-N
FDA UNII
76K53XP4TO

Racecadotril
Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
1 2D Structure

Racecadotril

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
benzyl 2-[[2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]acetate
2.1.2 InChI
InChI=1S/C21H23NO4S/c1-16(23)27-15-19(12-17-8-4-2-5-9-17)21(25)22-13-20(24)26-14-18-10-6-3-7-11-18/h2-11,19H,12-15H2,1H3,(H,22,25)
2.1.3 InChI Key
ODUOJXZPIYUATO-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC2=CC=CC=C2
2.2 Other Identifiers
2.2.1 UNII
76K53XP4TO
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Acetorphan

2. Acetorphan, (r)-isomer

3. Acetorphan, (s)-isomer

4. Ecadotril

5. N-(3-acetylmercapto-2-benzylpropanoyl)glycine Benzyl Ester

6. Retorphan

7. Sinorphan

2.3.2 Depositor-Supplied Synonyms

1. 81110-73-8

2. Acetorphan

3. Benzyl 2-(3-(acetylthio)-2-benzylpropanamido)acetate

4. Hidrasec

5. Tiorfan

6. Racecadotril [inn]

7. Tiorfix

8. S049; Sinorphan

9. Racecadotril (acetorphan)

10. Nsc-759828

11. 76k53xp4to

12. Benzyl 2-[[2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]acetate

13. Benzyl (3-(acetylthio)-2-benzylpropanoyl)glycinate

14. Racecadotril (inn)

15. Glycine, N-[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]-,phenylmethyl Ester [cas]

16. Glycine, N-[(2r)-2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]-, Phenylmethyl Ester

17. Smr000449320

18. Sr-01000759384

19. Racecadotril [inn:ban]

20. Unii-76k53xp4to

21. (+/-)-acetorphan

22. Benzyl 2-[[(2s)-2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]acetate

23. 2-[[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]amino]acetic Acid (phenylmethyl) Ester

24. 2-{[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]amino}acetic Acid (phenylmethyl) Ester

25. Hidrasec (tn)

26. Prestwick_926

27. Racecadotril-[d5]

28. Tiorfan (tn)

29. Mfcd00865520

30. Cpd000449320

31. Prestwick0_000626

32. Prestwick1_000626

33. Prestwick2_000626

34. Prestwick3_000626

35. Racecadotril [mi]

36. Acetorphan [vandf]

37. (+-)-n-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine Phenylmethyl Ester

38. Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, Phenylmethyl Ester

39. Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, Phenylmethyl Ester, (+-)-

40. Bspbio_000592

41. Racecadotril [mart.]

42. Mls000758279

43. Mls001423958

44. Mls006010032

45. Racecadotril [who-dd]

46. Schembl373243

47. Spbio_002811

48. Bpbio1_000652

49. Chembl2103772

50. Dtxsid8045513

51. Chebi:91508

52. Gtpl11654

53. Racecadotril, >=98% (hplc)

54. Hms1569n14

55. Hms2051k05

56. Hms2090l07

57. Hms2096n14

58. Hms2232f17

59. Hms3370b22

60. Hms3393k05

61. Hms3656c10

62. Hms3713n14

63. Hms3744i15

64. Hms3884f04

65. Pharmakon1600-01502331

66. Racecadotril [ep Monograph]

67. Bcp14746

68. Bcp22637

69. Racecadotril For Peak Identification

70. Bdbm50247884

71. Nsc759828

72. S2503

73. Akos015894948

74. Ab07493

75. Ac-1133

76. Ccg-100764

77. Ccg-213824

78. Cs-1127

79. Db11696

80. Hs-0029

81. Nc00014

82. Nsc 759828

83. (+-)-n-(alpha-(mercaptomethyl)hydrocinnamoyl)glycine, Benzyl Ester, Acetate (ester)

84. Ncgc00179511-01

85. Ncgc00179511-04

86. Br164305

87. Hy-17399

88. Sinorphan;bay Y 7432; Bay-y 7432

89. Db-015177

90. Ft-0602523

91. Ft-0700652

92. R0103

93. Sw197043-4

94. D08464

95. 110r738

96. A840045

97. Q416677

98. Sr-01000759384-4

99. Sr-01000759384-5

100. Benzyl N-[3-(acetylthio)-2-benzylpropionyl]glycinate

101. Brd-a08187463-001-03-8

102. N-[3-acetylthio-2-benzylpropanoyl]glycine Benzyl Ester

103. N-[3-(acetylthio)-2-benzylpropionyl]glycine Benzyl Ester

104. Racecadotril, European Pharmacopoeia (ep) Reference Standard

105. N-((r,s)-3-acetylthio-2-benzylpropanoyl)glycine Benzyl Ester

106. (2-acetylsulfanylmethyl-3-phenyl-propionylamino)-acetic Acid Benzyl Ester

107. Benzyl 2-[[2-(acetylsulfanylmethyl)-3-phenyl-propanoyl]amino]acetate;racecadotril

108. Racecadotril For Peak Identification, European Pharmacopoeia (ep) Reference Standard

109. (+/-)-n-(.alpha.-(mercaptomethyl)hydrocinnamoyl)glycine, Benzyl Ester, Acetate (ester)

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 385.5 g/mol
Molecular Formula C21H23NO4S
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count11
Exact Mass385.13477939 g/mol
Monoisotopic Mass385.13477939 g/mol
Topological Polar Surface Area97.8 Ų
Heavy Atom Count27
Formal Charge0
Complexity485
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antidiarrheals

Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition. (See all compounds classified as Antidiarrheals.)


Protease Inhibitors

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES). (See all compounds classified as Protease Inhibitors.)


4.2 ATC Code

A - Alimentary tract and metabolism

A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents

A07X - Other antidiarrheals

A07XA - Other antidiarrheals

A07XA04 - Racecadotril


API Reference Price

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17-Jan-2022
24-Apr-2025
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Racecadotril

Brand Name : Tiorfix

Dosage Form :

Dosage Strength : To 20 Cps 100 Mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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02

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Racecadotril

Brand Name : Tiorfix

Dosage Form :

Dosage Strength : Early Childhood 16 Bust Grat 10 Mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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03

Peptide Forum
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Peptide Forum
Not Confirmed

Racecadotril

Brand Name : Tiorfix

Dosage Form :

Dosage Strength : Bb 16 Bust Grat 30 Mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Italy

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04

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Not Confirmed

Racecadotril

Brand Name : Hidrasec

Dosage Form : Granules to potion, suspension

Dosage Strength : 10 mg

Packaging : Dose Bag

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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05

Peptide Forum
Not Confirmed
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Peptide Forum
Not Confirmed

Racecadotril

Brand Name : Hidrasec

Dosage Form : Granules to potion, suspension

Dosage Strength : 30 mg

Packaging : Dose Bag

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

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ABOUT THIS PAGE

Looking for 81110-73-8 / Racecadotril API manufacturers, exporters & distributors?

Racecadotril manufacturers, exporters & distributors 1

87

PharmaCompass offers a list of Racecadotril API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Racecadotril manufacturer or Racecadotril supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Racecadotril manufacturer or Racecadotril supplier.

PharmaCompass also assists you with knowing the Racecadotril API Price utilized in the formulation of products. Racecadotril API Price is not always fixed or binding as the Racecadotril Price is obtained through a variety of data sources. The Racecadotril Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Racecadotril

Synonyms

81110-73-8, Acetorphan, Benzyl 2-(3-(acetylthio)-2-benzylpropanamido)acetate, Hidrasec, Tiorfan, Racecadotril [inn]

Cas Number

81110-73-8

Unique Ingredient Identifier (UNII)

76K53XP4TO

About Racecadotril

Racecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.

Racecadotril Manufacturers

A Racecadotril manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Racecadotril, including repackagers and relabelers. The FDA regulates Racecadotril manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Racecadotril API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Racecadotril manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Racecadotril Suppliers

A Racecadotril supplier is an individual or a company that provides Racecadotril active pharmaceutical ingredient (API) or Racecadotril finished formulations upon request. The Racecadotril suppliers may include Racecadotril API manufacturers, exporters, distributors and traders.

click here to find a list of Racecadotril suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Racecadotril KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Racecadotril Drug Master File in Korea (Racecadotril KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Racecadotril. The MFDS reviews the Racecadotril KDMF as part of the drug registration process and uses the information provided in the Racecadotril KDMF to evaluate the safety and efficacy of the drug.

After submitting a Racecadotril KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Racecadotril API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Racecadotril suppliers with KDMF on PharmaCompass.

Racecadotril CEP

A Racecadotril CEP of the European Pharmacopoeia monograph is often referred to as a Racecadotril Certificate of Suitability (COS). The purpose of a Racecadotril CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Racecadotril EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Racecadotril to their clients by showing that a Racecadotril CEP has been issued for it. The manufacturer submits a Racecadotril CEP (COS) as part of the market authorization procedure, and it takes on the role of a Racecadotril CEP holder for the record. Additionally, the data presented in the Racecadotril CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Racecadotril DMF.

A Racecadotril CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Racecadotril CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Racecadotril suppliers with CEP (COS) on PharmaCompass.

Racecadotril WC

A Racecadotril written confirmation (Racecadotril WC) is an official document issued by a regulatory agency to a Racecadotril manufacturer, verifying that the manufacturing facility of a Racecadotril active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Racecadotril APIs or Racecadotril finished pharmaceutical products to another nation, regulatory agencies frequently require a Racecadotril WC (written confirmation) as part of the regulatory process.

click here to find a list of Racecadotril suppliers with Written Confirmation (WC) on PharmaCompass.

Racecadotril GMP

Racecadotril Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Racecadotril GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Racecadotril GMP manufacturer or Racecadotril GMP API supplier for your needs.

Racecadotril CoA

A Racecadotril CoA (Certificate of Analysis) is a formal document that attests to Racecadotril's compliance with Racecadotril specifications and serves as a tool for batch-level quality control.

Racecadotril CoA mostly includes findings from lab analyses of a specific batch. For each Racecadotril CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Racecadotril may be tested according to a variety of international standards, such as European Pharmacopoeia (Racecadotril EP), Racecadotril JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Racecadotril USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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