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    Chemistry

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    Also known as: 1332-58-7, China clay, Argilla, Porcelain clay, Bolus alba, White bole
    Molecular Formula
    Al2H4O9Si2
    Molecular Weight
    258.16  g/mol
    InChI Key
    NLYAJNPCOHFWQQ-UHFFFAOYSA-N
    Kaolin
    The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: "high ridge"), the original site. (From Grant and Hackh's Chemical Dictionary, 5th ed)
    1 2D Structure

    Kaolin

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    oxo-oxoalumanyloxy-[oxo(oxoalumanyloxy)silyl]oxysilane;dihydrate
    2.1.2 InChI
    InChI=1S/2Al.O5Si2.2H2O.2O/c;;1-6(2)5-7(3)4;;;;/h;;;2*1H2;;/q2*+1;-2;;;;
    2.1.3 InChI Key
    NLYAJNPCOHFWQQ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Kaolinite

    2.2.2 Depositor-Supplied Synonyms

    1. 1332-58-7

    2. China Clay

    3. Argilla

    4. Porcelain Clay

    5. Bolus Alba

    6. White Bole

    7. Kaolin(superfine)

    8. Glomax

    9. Light Kaolin

    10. Hydrated Aluminum Silicate

    11. Kaolin Clay Slurry

    12. Bentone

    13. Alphagloss

    14. Altowhites

    15. Alfaplate

    16. Alphacoat

    17. Altowhite

    18. Apsilex

    19. Argiflex

    20. Comalco

    21. Electros

    22. Emathlite

    23. Hydrite

    24. Kaopaous

    25. Langford

    26. Mcnamee

    27. Parclay

    28. Vanclay

    29. Fitrol

    30. Arcilla Blanca

    31. Oxo-oxoalumanyloxy-[oxo(oxoalumanyloxy)silyl]oxysilane;dihydrate

    32. Argilla Alba

    33. Comalco Kaolin

    34. Osmo Kaolin

    35. Kaolin Colloidal

    36. Beta Coat

    37. Astra-glaze

    38. Snow Tex

    39. Asp Ultrafine

    40. Kao-gel

    41. Century Hc

    42. Kaophills-2

    43. Aa Kaolin

    44. Clay (kaolin)

    45. Acidic White Clays

    46. Bol Blanc

    47. Asp (mineral)

    48. Burgess 10

    49. Airflo V 8

    50. Amazon 88

    51. Amazon 90

    52. Argirec B 22

    53. Argirec Kn 15

    54. Bilt Plate 156

    55. Fitrol Desiccite 25

    56. Clays, White, Acidic

    57. Amazon Kaolin 855d

    58. Kaolin [usp:jan]

    59. Cb 1 (clay)

    60. Cb 2 (clay)

    61. Clay 347

    62. Aluminum Silicate Hydroxide

    63. Unii-24h4nwx5co

    64. Metakaolin

    65. Kaolinum

    66. Clay Nanopowder

    67. Clay Slurry

    68. Kaolin Nanoclay

    69. Nanoclay Powder

    70. Ccris 9288

    71. Hsdb 630

    72. Perlite Clay Mix

    73. Clay Nanoparticles

    74. Epa Pesticide Chemical Code 100104

    75. Expanded Perlite Powder

    76. Perlite Nanoclay Powder

    77. Halloysite Clay Nanotubes

    78. Aluminium Silicate Dihydrate

    79. Aluminum Silicate (hydrated)

    80. Nanoclay Montmorillonite 20a

    81. Expanded Perlite Nanoparticles

    82. Montmorillonite Bentonite Clay

    83. Halloysite Nanotubes Properties

    84. Chembl3833365

    85. Chebi:140503

    86. Nanoclay Modified Asphalt Materials

    87. Expanded Perlite Powder / Nanopowder

    88. Shelsite 30b Montmorillonite Nanoparticles

    89. Ft-0627569

    90. J-521617

    91. 95077-05-7

    2.3 Create Date
    2012-03-21
    3 Chemical and Physical Properties
    Molecular Weight 258.16 g/mol
    Molecular Formula Al2H4O9Si2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count4
    Exact Mass257.902462 g/mol
    Monoisotopic Mass257.902462 g/mol
    Topological Polar Surface Area98 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity167
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Antidiarrheals; Pharmaceutic Aids

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    /Kaolin/ either alone or as...mixt with pectin, is used medicinally as an adsorbent...of value chiefly in treatment of diarrhea caused by agents capable of being adsorbed, as, for example, diarrhea of food poisoning or dysentery.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 751

    Kaolin has...been used in treatment of chronic ulcerative colitis, but it is doubtful whether any adsorptive capacity is retained by time prepn reaches colon.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 751

    VET: adsorbent, protective antidiarrheal. A physical adsorbent with hydrophilic capacity. Topical skin & GI protectant. It incr bulk & slows .. Passage of feces. Has/ ability to absorb toxins...topically & intrauterine in addn to GI.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 297

    For more Therapeutic Uses (Complete) data for KAOLIN (8 total), please visit the HSDB record page.

    4.2 Drug Warning

    ... Formulation changes ... have occurred with Kaopectate ... The current Kaopectate marketed is not the formulation ... with Kaolin and Pectin. In the late 1980's or early '90s, the manufacturer reformulated the product to contain attapulgite. Then in 2003, the sponsor reformulated the product again, this time to include bismuth subsalicylate as the active ingredient. ...

    FDA Safety Drug Page. Drug Topics April 19, 2004. Available from the website www.fda.gov/cder/drug/mederrors/kaopectate.pdf as of July 25, 2007

    If/...kaolin-containing product must be used...should be given...2 hr before lincomycin. If this...proves impractical, lincomycin may be administered by injection or a nondiarrhea-producing antibiotic should be substituted.

    Evaluations of Drug Interactions. 2nd ed. and supplements. Washington, DC: American Pharmaceutical Assn., 1976, 1978., p. 136

    Inert except for dangers of obstruction, perforation, & granuloma formation.

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-95

    The use of antidiarrheal mixtures containing opioids or poorly absorbed antibacterial agents with adsorbents and protectants (most commonly, kaolin and pectin) and antispasmodic agents is unwarranted, since additional benefits beyond those afforded by the single effective agent are questionable and the patient is subjected to the added expense and the combined adverse effects of the individual ingredients.

    American Medical Association, Council on Drugs. AMA Drug Evaluations Annual 1994. Chicago, IL: American Medical Association, 1994., p. 935

    4.3 Minimum/Potential Fatal Human Dose

    Practically non-toxic: probable oral lethal dose (human) above 15 g/kg; more than 1 quart (2.2 lb) for 70 kg person (150 lb).

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-95

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antidiarrheals

    Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition. (See all compounds classified as Antidiarrheals.)

    5.2 ATC Code

    A - Alimentary tract and metabolism

    A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents

    A07B - Intestinal adsorbents

    A07BC - Other intestinal adsorbents

    A07BC02 - Kaolin

    5.3 Absorption, Distribution and Excretion

    Kaolin and pectin are not absorbed following oral administration.

    McEvoy, G.K. (ed.). American Hospital Formulary Service--Drug Information 94. Bethesda, MD: American Society of Hospital Pharmacists, Inc. 1994 (Plus Supplements)., p. 1879

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    [{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1634754600,"product":"PERKADOX 14-40K-PD-S DI(TERT-BUTYLPEROXYISOPROPYL) BENZENE40% ACTIVE INGREDIENT ON KAOLIN CLAY IN POWDER","address":"2106 \/ 5 BRIJWASI INDUSTRIAL ESTAT E,GROUND FLOOR I B PATEL ROAD","city":"GOREGAON EAST,MAHARASHTRA","supplier":"NOURYON FUNCTIONAL CHEMICALS ","supplierCountry":"GERMANY","foreign_port":"NA","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"2400.00","actualQuantity":"2400","unit":"KGS","unitRateFc":"5.8","totalValueFC":"16229.4","currency":"EUR","unitRateINR":"506.6","date":"21-Oct-2021","totalValueINR":"1215780","totalValueInUsd":"16229.4","indian_port":"JNPT","hs_no":"29096000","bill_no":"5924473","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"2106 \/ 5 BRIJWASI INDUSTRIAL ESTAT E,GROUND FLOOR I B PATEL ROAD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702319400,"product":"PERKADOX 14-40K-PD-S DI(TERT-BUTYLPEROXYISOPROPYL) BENZENE40% ACTIVE INGREDIENT ON KAOLIN CLAY IN POWDER","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON FUNCTIONAL CHEMICALS ","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"2400.00","actualQuantity":"2400","unit":"KGS","unitRateFc":"466.9","totalValueFC":"14956.3","currency":"INR","unitRateINR":"518.8","date":"12-Dec-2023","totalValueINR":"1245009.53","totalValueInUsd":"14956.3","indian_port":"JNPT","hs_no":"29096000","bill_no":"9193096","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"HAAKSBERGWEG 88 1101 BZAMSTERDAM POBOX 873621080 JJ AMSTERDAMSDNF NETHERLANDS","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704997800,"product":"PERKADOX 14-40K-PD-S DI(TERT-BUTYLPEROXYISOPROPYL) BENZENE40% ACTIVE INGREDIENT ON KAOLIN CLAY IN POWDER","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON FUNCTIONAL CHEMICALS ","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"2400.00","actualQuantity":"2400","unit":"KGS","unitRateFc":"466.9","totalValueFC":"14980","currency":"INR","unitRateINR":"518.8","date":"12-Jan-2024","totalValueINR":"1245009.53","totalValueInUsd":"14980","indian_port":"JNPT","hs_no":"29096000","bill_no":"9629668","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"HAAKSBERGWEG 88 1101 BZAMSTERDAM POBOX 873621080 JJ AMSTERDAMSDNF NETHERLANDS","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725301800,"product":"PERKADOX 14-40K-PD-S DI(TERT-BUTYLPEROXYISOPROPYL) BENZENE40% ACTIVE INGREDIENT ON KAOLIN CLAY IN POWDER","address":"NARAYAN PLAZA,UNIT NO A 7,26 A ,","city":"ANDHERI(E)MUMBAI","supplier":"NOURYON FUNCTIONAL CHEMICALS ","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"M K MARKETING","customerCountry":"INDIA","quantity":"400.00","actualQuantity":"400","unit":"KGS","unitRateFc":"466.9","totalValueFC":"2773.2","currency":"INR","unitRateINR":"581","date":"03-Sep-2024","totalValueINR":"232398.37","totalValueInUsd":"2773.2","indian_port":"JNPT","hs_no":"29096000","bill_no":"5389511","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"HAAKSBERGWEG 88 1101 BZAMSTERDAM PO BOX 873621080 JJ AMSTERDAM SDNF NETHERLANDS NETHERLANDS","customerAddress":"NARAYAN PLAZA,UNIT NO A 7,26 A ,"}]
    21-Oct-2021
    03-Sep-2024
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    ABOUT THIS PAGE

    Looking for 1332-58-7 / Kaolin API manufacturers, exporters & distributors?

    Kaolin manufacturers, exporters & distributors 1

    26

    PharmaCompass offers a list of Kaolin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Kaolin manufacturer or Kaolin supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Kaolin manufacturer or Kaolin supplier.

    PharmaCompass also assists you with knowing the Kaolin API Price utilized in the formulation of products. Kaolin API Price is not always fixed or binding as the Kaolin Price is obtained through a variety of data sources. The Kaolin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Kaolin

    Synonyms

    1332-58-7, China clay, Argilla, Porcelain clay, Bolus alba, White bole

    Cas Number

    1332-58-7

    About Kaolin

    The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: "high ridge"), the original site. (From Grant and Hackh's Chemical Dictionary, 5th ed)

    Kaolin Manufacturers

    A Kaolin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Kaolin, including repackagers and relabelers. The FDA regulates Kaolin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Kaolin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Kaolin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Kaolin Suppliers

    A Kaolin supplier is an individual or a company that provides Kaolin active pharmaceutical ingredient (API) or Kaolin finished formulations upon request. The Kaolin suppliers may include Kaolin API manufacturers, exporters, distributors and traders.

    click here to find a list of Kaolin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Kaolin WC

    A Kaolin written confirmation (Kaolin WC) is an official document issued by a regulatory agency to a Kaolin manufacturer, verifying that the manufacturing facility of a Kaolin active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Kaolin APIs or Kaolin finished pharmaceutical products to another nation, regulatory agencies frequently require a Kaolin WC (written confirmation) as part of the regulatory process.

    click here to find a list of Kaolin suppliers with Written Confirmation (WC) on PharmaCompass.

    Kaolin GMP

    Kaolin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Kaolin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Kaolin GMP manufacturer or Kaolin GMP API supplier for your needs.

    Kaolin CoA

    A Kaolin CoA (Certificate of Analysis) is a formal document that attests to Kaolin's compliance with Kaolin specifications and serves as a tool for batch-level quality control.

    Kaolin CoA mostly includes findings from lab analyses of a specific batch. For each Kaolin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Kaolin may be tested according to a variety of international standards, such as European Pharmacopoeia (Kaolin EP), Kaolin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Kaolin USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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