Find Antroquinonol manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

API REF. PRICE (USD/KG)

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Regulatory FDF Prices

NA

API/FDF Prices: Book a Demo to
explore the features and consider
upgrading later

MARKET PLACE

0

API

0

FDF

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Hocena, Antroquinonol a, (+)-antroquinonol a, 1010081-09-0, (+)-antroquinonol, Ax9p92t7jz
Molecular Formula
C24H38O4
Molecular Weight
390.6  g/mol
InChI Key
LJTSIMVOOOLKOL-FNRDIUJOSA-N
FDA UNII
AX9P92T7JZ

Antroquinonol
Antroquinonol Capsule is an orally available capsule containing antroquinonol, a farnesylated quinone derivative isolated from the mycelium of Antrodia camphorata, with potential antineoplastic activity. Upon oral administration, antroquinonol binds to and inhibits protein prenylation mediated by the enzymes farnesyltransferase (FTase) and geranylgeranyltransferase 1 (GGTase-1). This prevents both post-translational prenylation and signaling activity of a number of Ras superfamily proteins, such as Ras and Rho. This results in the inhibition of downstream signaling, such as the PI3K/mTOR signaling pathway, and induces apoptosis in susceptible tumor cells. Ras superfamily proteins are overexpressed in numerous cancer cell types, and play a key role in tumor cell proliferation and survival.
1 2D Structure

Antroquinonol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R,5R,6R)-4-hydroxy-2,3-dimethoxy-6-methyl-5-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]cyclohex-2-en-1-one
2.1.2 InChI
InChI=1S/C24H38O4/c1-16(2)10-8-11-17(3)12-9-13-18(4)14-15-20-19(5)21(25)23(27-6)24(28-7)22(20)26/h10,12,14,19-20,22,26H,8-9,11,13,15H2,1-7H3/b17-12+,18-14+/t19-,20-,22-/m1/s1
2.1.3 InChI Key
LJTSIMVOOOLKOL-FNRDIUJOSA-N
2.1.4 Canonical SMILES
CC1C(C(C(=C(C1=O)OC)OC)O)CC=C(C)CCC=C(C)CCC=C(C)C
2.1.5 Isomeric SMILES
C[C@@H]1[C@H]([C@H](C(=C(C1=O)OC)OC)O)C/C=C(\C)/CC/C=C(\C)/CCC=C(C)C
2.2 Other Identifiers
2.2.1 UNII
AX9P92T7JZ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (+)-antroquinonol A

2. Antroquinonol A

3. Antroquinonol D

2.3.2 Depositor-Supplied Synonyms

1. Hocena

2. Antroquinonol A

3. (+)-antroquinonol A

4. 1010081-09-0

5. (+)-antroquinonol

6. Ax9p92t7jz

7. Chebi:65415

8. J3.387.174k

9. Antroquinonol D

10. (4r,5r,6r)-4-hydroxy-2,3-dimethoxy-6-methyl-5-((2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)cyclohex-2-en-1-one

11. (4r,5r,6r)-4-hydroxy-2,3-dimethoxy-6-methyl-5-((2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)cyclohex-2-enone

12. (4r,5r,6r)-4-hydroxy-2,3-dimethoxy-6-methyl-5-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]cyclohex-2-en-1-one

13. 2-cyclohexen-1-one, 4-hydroxy-2,3-dimethoxy-6-methyl-5-((2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)-, (4r,5r,6r)-

14. Unii-ax9p92t7jz

15. Antroquinonol [who-dd]

16. Chembl3235620

17. Schembl16919581

18. Db12326

19. Hy-19893

20. Cs-0016956

21. Q27133859

22. (4r)-2,3-dimethoxy-4.alpha.-hydroxy-5.alpha.-((2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrienyl)-6.beta.-methyl-2-cyclohexene-1-one

23. (4r)-2,3-dimethoxy-4alpha-hydroxy-5alpha-((2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrienyl)-6beta-methyl-2-cyclohexene-1-one

24. (4r,5r,6r)-4-hydroxy-2,3-dimethoxy-6-methyl-5-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trienyl]cyclohex-2-en-1-one

2.4 Create Date
2008-08-18
3 Chemical and Physical Properties
Molecular Weight 390.6 g/mol
Molecular Formula C24H38O4
XLogP35.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count10
Exact Mass390.27700969 g/mol
Monoisotopic Mass390.27700969 g/mol
Topological Polar Surface Area55.8 Ų
Heavy Atom Count28
Formal Charge0
Complexity648
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Looking for 1010081-09-0 / Antroquinonol API manufacturers, exporters & distributors?

Antroquinonol manufacturers, exporters & distributors 1

98

PharmaCompass offers a list of Antroquinonol API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Antroquinonol manufacturer or Antroquinonol supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Antroquinonol manufacturer or Antroquinonol supplier.

PharmaCompass also assists you with knowing the Antroquinonol API Price utilized in the formulation of products. Antroquinonol API Price is not always fixed or binding as the Antroquinonol Price is obtained through a variety of data sources. The Antroquinonol Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Antroquinonol

Synonyms

Hocena, Antroquinonol a, (+)-antroquinonol a, 1010081-09-0, (+)-antroquinonol, Ax9p92t7jz

Cas Number

1010081-09-0

Unique Ingredient Identifier (UNII)

AX9P92T7JZ

About Antroquinonol

Antroquinonol Capsule is an orally available capsule containing antroquinonol, a farnesylated quinone derivative isolated from the mycelium of Antrodia camphorata, with potential antineoplastic activity. Upon oral administration, antroquinonol binds to and inhibits protein prenylation mediated by the enzymes farnesyltransferase (FTase) and geranylgeranyltransferase 1 (GGTase-1). This prevents both post-translational prenylation and signaling activity of a number of Ras superfamily proteins, such as Ras and Rho. This results in the inhibition of downstream signaling, such as the PI3K/mTOR signaling pathway, and induces apoptosis in susceptible tumor cells. Ras superfamily proteins are overexpressed in numerous cancer cell types, and play a key role in tumor cell proliferation and survival.

Antroquinonol Manufacturers

A Antroquinonol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Antroquinonol, including repackagers and relabelers. The FDA regulates Antroquinonol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Antroquinonol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Antroquinonol Suppliers

A Antroquinonol supplier is an individual or a company that provides Antroquinonol active pharmaceutical ingredient (API) or Antroquinonol finished formulations upon request. The Antroquinonol suppliers may include Antroquinonol API manufacturers, exporters, distributors and traders.

Antroquinonol GMP

Antroquinonol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Antroquinonol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Antroquinonol GMP manufacturer or Antroquinonol GMP API supplier for your needs.

Antroquinonol CoA

A Antroquinonol CoA (Certificate of Analysis) is a formal document that attests to Antroquinonol's compliance with Antroquinonol specifications and serves as a tool for batch-level quality control.

Antroquinonol CoA mostly includes findings from lab analyses of a specific batch. For each Antroquinonol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Antroquinonol may be tested according to a variety of international standards, such as European Pharmacopoeia (Antroquinonol EP), Antroquinonol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Antroquinonol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty