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5-Aza-t-dcyd manufacturers, exporters & distributors
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API | Excipient name
5-Aza-t-dcyd
Synonyms
U2ptn0rzf6, 169514-76-5, 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]-1,3,5-triazin-2-one, Unii-u2ptn0rzf6, Schembl19244084, 4-amino-1(2'-deoxy-4-thio-.beta.-d-erythropentofuranosyl)-1,3,5-triazin-2(1h)-one
Unique Ingredient Identifier (UNII)
U2PTN0RZF6
About 5-Aza-t-dcyd
5-Aza-4'-thio-2'-deoxycytidine is an orally bioavailable, nucleoside analog and DNA methyltransferase I (DNMT1) inhibitor, with potential DNA hypomethylating and antineoplastic activities. Upon administration, 5-aza-4'-thio-2'-deoxycytidine (Aza-TdC) gets incorporated into DNA, where it binds to the active site of DNMT1, a maintenance methyltransferase that contributes to the hypermethylation and silencing of tumor suppressor genes. The formation of covalent DNMT1-DNA complexes inhibits DNMT1, prevents DNA methylation of CpG sites, causes CpG demethylation, and results in the re-expression and re-activation of silenced tumor suppressor genes. This inhibits tumor cell proliferation. DNMT1, overactivated in tumor cells, plays a key role in tumor cell proliferation.