Xalud Therapeutics has shifted its internal plans, sending its lead non-viral gene therapy on the partnering path, elevating a preclinical ALS program and letting employees go.
Xalud Therapeutics Presents Clinical Data on XT-150 in Knee Osteoarthritis at the 2023 Osteoarthritis Research Society International World Congress
NEW YORK, June 06, 2022 (GLOBE NEWSWIRE) -- Xalud Therapeutics, a clinical-stage biotechnology company developing novel non-viral gene therapies to treat pathologic inflammation, announced today...
NEW YORK--(BUSINESS WIRE)--Xalud Therapeutics, a clinical-stage biotechnology company developing DNA-delivered therapeutics, today announced the first patient dosed in a Phase 2a clinical trial of its lead product candidate, XT-150, for the treatment of facet joint osteoarthritis (FJOA) pain. XT-150 is a locally-injectable plasmid DNA gene therapy expressing IL-10v, a proprietary modified variant of human interleukin-10 (IL-10). XT-150 is currently being evaluated in additional clinical trials for the treatment of osteoarthritis of the knee and neuropathic pain.
NEW YORK--(BUSINESS WIRE)--Xalud Therapeutics, a clinical-stage biotechnology company developing DNA delivery therapies using a non-viral platform, announced today that the United States Food and Drug Administration (FDA) has granted Fast Track designation to the Company’s lead candidate, XT-150, for the treatment of pain associated with osteoarthritis of the knee. XT-150 is a locally injectable non-viral therapy expressing IL-10v, a proprietary modified variant of IL-10, that addresses pathologic inflammation and pain.
UK TCR-focused biotech Immunocore announced that it scored a priority review with the FDA for lead drug tebentafusp.
NEW YORK--(BUSINESS WIRE)--Xalud Therapeutics, a clinical-stage biotechnology company developing novel non-viral gene therapies to treat pathologic inflammation through immune modulation, today announced that the Phase 2b study of XT-150 in patients with moderate-to-severe pain due to osteoarthritis (OA) of the knee has completed enrollment. Xalud has recently presented promising data from three of its previously completed Phase 1b/2a studies in the same indication in a poster presentation at the Osteoarthritis Research Society International (OARSI) Virtual World Congress held on April 29 – May 1, 2021. XT-150 is a locally injectable, plasmid DNA gene therapy expressing IL-10v, a proprietary modified variant of the cytokine IL-10, to address pathologic inflammation and pain. The company also announced the initiation of their neuropathic pain clinical program with the first patient dosed in the Phase 1/2a study in patients with radicular neuropathic pain due to lumbar disc disease.