Sophia Antipolis, France – 28 Aug 2021: Edoxaban is noninferior to warfarin and its analogues for adverse clinical events in patients with atrial fibrillation after transcatheter aortic valve implantation (TAVI). That’s the finding of late breaking research presented in a Hot Line session today at ESC Congress 20211 and published in the New England Journal of Medicine.2 The incidence of major bleeding was higher with edoxaban compared with vitamin K antagonists (VKAs).
ATLANTA -- New research presented at ACR Convergence, the American College of Rheumatology's annual meeting, shows that use of warfarin, a vitamin K drug widely prescribed to prevent blood clots, is associated with a significantly greater risk of knee and hip replacements in patients with osteoarthritis (ABSTRACT #0934).
Portola Pharmaceuticals, Inc.® (Nasdaq: PTLA) today announced new data reinforcing the value of Andexxa® [coagulation factor Xa (recombinant), inactivated-zhzo], the first and only FDA-approved reversal agent for the Factor Xa inhibitors rivaroxaban or apixaban. The data demonstrated that Andexxa was associated with a lower rate of in-hospital and 30-day mortality in patients with life-threatening Factor Xa inhibitor-related bleeds compared with other treatment options. This included lower mortality across multiple bleed types including intracranial hemorrhage (ICH), gastrointestinal bleeding (GI) and bleeding due to trauma, when compared to 4-factor prothrombin complex concentrate (4F-PCC) therapy, which is approved only for the reversal of warfarin.
XARELTO® (rivaroxaban) Significantly Reduced the Risk of Overall Strokes and the Most Severe Strokes and Was Associated with Fewer Stroke-Related Deaths in the Real World Versus Warfarin in Patients with Nonvalvular Atrial Fibrillation
Cereno Scientific is currently in the clinical phase of developing a new drug with the potential to redefine thrombosis prevention without causing an increased risk of bleeding.
(Reuters Health) - More patients with heart rhythm problems that put them at high risk for stroke are taking daily pills to prevent clotting - and they’re having fewer strokes as a result, a Swedish study suggests.
Armetheon, a specialty pharmaceutical company developing novel small molecule drugs for cardiovascular diseases, has announced that it has received advice from the European Medicines Agency (EMA) Scientific Advice Working Group (SAWG) for the development of its novel oral anticoagulant tecarfarin. The SAWG advised that Armetheon can conduct a single1000 patient pivotal study prior to filing the Market Authorization Application (MAA) for tecarfarin. If approved, tecarfarin is positioned to potentially be the oral anticoagulant (OAC) therapy of choice for patients who require anticoagulation with a vitamin K antagonist (VKA), such as warfarin. This includes patients with prosthetic heart valves (PHV), repeat deep vein thrombosis or patients with chronic kidney disease (CKD) which complicates anticoagulant therapy. This pivotal trial will enroll patients with all indications for anticoagulation, thereby supporting a potential broad label if the product is approved.
The Alere INRatio and INRatio2 PT/INR Monitor System are devices used to measure how fast a patient’s blood is clotting. This system is used in patients taking warfarin, a decades-old anticoagulant used to prevent blood clot and stroke in patients with atrial fibrillation. The Alere INRatio and INRatio2 were recalled in 2014, and a voluntary withdrawal was initiated in 2016.
In its Q3 earnings presentation, Johnson & Johnson rolled out a graph of total prescription share that showed Bristol-Myers Squibb and Pfizer's Eliquis steadily gaining on its own market leader, Xarelto.
Boehringer Ingelheim Pharmaceuticals, Inc. today announced the enrollment of the first patient in RE-COVERY DVT/PE™, a global observational study on the management of blood clots in the legs (deep vein thrombosis, DVT) and in the lungs (pulmonary embolism, PE). The new study will provide insights into how patients with DVT and PE are being treated in real-world clinical practice, and will add to the growing body of data on the effectiveness and safety of Pradaxa® (dabigatran etexilate mesylate) compared to warfarin.