VITRAC Therapeutics Initiates a Phase 1 Clinical Trial with the Aurora Kinase A Inhibitor VIC-1911 and G12C Inhibitor Sotorasib for the Treatment of KRAS G12C-Mutant Non-Small Cell Lung Cancer
BOSTON--(BUSINESS WIRE)--VITRAC Therapeutics, LLC (VITRAC) initiated a Phase 1/2 clinical trial of VIC-1911 in combination with sirolimus and post-transplant cyclophosphamide (PTCy) as graft-versus-host disease (GVHD) prophylaxis in myeloablative allogeneic stem cell transplantation. VIC-1911 is an oral selective Aurora kinase A inhibitor (AURKA). The trial is being carried out at the University of Minnesota Medical School, Hematology and Transplantation, with Shernan G. Holtan, M.D., the Principal Investigator, and Brian C. Betts, MD. The scientific rationale is based on preclinical work led by Dr. Betts, where AURKA inhibition reduced xenogeneic GVHD in mice and enhanced human regulatory T cell suppression over pathogenic, alloreactive T cells (Betts BC et al. Science Translational Medicine. 2017).