Sept 27 (Reuters) - Biohaven Pharmaceutical Holding Co Ltd (BHVN.N) said on Monday its drug candidate, verdiperstat, failed to show effectiveness in treating a rare neurological disorder called multiple system atrophy (MSA).
NEW HAVEN, Conn., July 21, 2020 /PRNewswire/ -- Biohaven Pharmaceutical Holding Company Ltd. (NYSE: BHVN) announced today that it has successfully completed enrollment in the M-STAR study, an international Phase 3 clinical trial evaluating the safety and efficacy of verdiperstat in multiple system atrophy (MSA). Verdiperstat is an investigational drug and potential first-in-class myeloperoxidase (MPO) inhibitor designed to target sources of neuroinflammation that contribute to brain cell death in neurodegenerative diseases including MSA and amyotrophic lateral sclerosis (ALS). Verdiperstat has received Orphan Drug and Fast Track designations for MSA from the U.S. Food and Drug Administration (FDA), as well as Orphan Drug designation from the European Medicines Agency.
Biohaven Pharmaceutical has licensed an experimental treatment of the neurodegenerative disorder multiple system atrophy (MSA) from AstraZeneca. The deal follows a midphase trial that linked oral myeloperoxidase (MPO) inhibitor AZD3241 to numerical improvements on a scale of MSA symptoms.
Biohaven Pharma has completed patient recruitment in a late-stage trial of migraine candidate rimegepant, which is looking like its best pipeline prospect after its rare-disease candidate hit a snag last month.