Despite flourishing domestic excipient units, India still imports huge quantities of excipients from various countries. Nitika MD said “A number of pharma companies still feel that imported excipients are better than domestic excipients. It takes a lot of time to build trust among pharma units about new excipients. Low cost and high quality Indian excipients are in high demand by middle and small companies.”
In wet granulation processes, coatings or binders generally consist of mixtures of various raw materials that confer or enhance specific properties to the final product. Typically, a coating solution is composed of water, film forming polymer (such as hydroxypropyl-methylcellulose, HPMC) and filler (such as stearic acid, SA).
In this study a gastric-retentive delivery system was prepared by a novel method which is reported here for the first time. An innovative floating and bioadhesive drug delivery system with a hollow structure was designed and prepared. The floating and bioadhesive drug delivery system was composed of a hollow spherical shell, a waterproof layer (Stearic acid), a drug layer (Ofloxacin), a release retarding film (the novel blended coating materials) and a bioadhesive layer (Carbomer 934P) prepared by using a liquid multi-layering process.