It is common practice within the pharmaceutical industry to enhance the aesthetic appearance of dosage forms by using suitably colored film coatings (1). Colored coatings increase patient acceptability and compliance, improve safety via easy identification and differentiation and may reduce degradation via increased opacity to light. Indigo Carmine (FD & C Blue #2) or Indigotine is approved in US and European Markets to be used as a colorant in oral and topical preparations. It is known to have good heat stability but poor stability to light and oxidizing agents. Thus formulations containing Indigo Carmine tend to fade with time.
BASF halts production at Ludwigshafen plant after deadly explosion
JRS PHARMA, headquartered in Germany, has entered into a joint venture agreement with SSP, headquartered in Chongqing, China, for the commercialization of povidone products. The new JV company is Star-Tech & JRS Specialty Products.
Specific values of technological properties of excipients allow the establishment of numerical parameters to de ne and compare their functionality. This study investigates the functionality of Polyplasdones XL and XL10.
This study evaluated the feasibility of liquisolid pellets as an innovative drug delivery system to improve the dissolution rate of low solubility drugs, combining the advantageous properties of multiple-unit dosage forms and the liquisolid formulations. The effects of crospovidone (Kollidon® CL-SF) as a coating and disintegrating material (4 or 8%) and the type of non-volatile solvent, PEG 400 or Cremophor® EL, on the felodipine (model drug) dissolution profile were assessed. All liquisolid formulations had increased drug dissolution rates compared to its correspondent conventional formulations. Cremophor® EL was more effective in improving the drug dissolution rate when compared to PEG 400 due to the formation of softer and more porous structures.