Tempero Bio, Inc, a clinical-stage biopharmaceutical company focused on developing transformative therapies for the treatment and prevention of alcohol and other substance use disorders, today announced the U.S. Food and Drug Administration (FDA) clearance of its Investigational New Drug (IND) application for TMP-301. TMP-301 is the Company's investigational metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM) candidate, poised for a lead indication in the treatment of cocaine use disorders (CUD).