A tumultuous stretch for Scandion Oncology apparently has more treacherous terrain ahead. The company announced Friday a critical trial failure just one month after the CEO and chief operating officer announced their departures.
Scandion Oncology A/S, the Cancer Drug Resistance Company, today announced that the company has obtained approval from the Danish Medicines Agency and the Ethics Com-mittee in Denmark of the amendment of part 2 of the CORIST Phase II study. This means that the company can commence the inclusion of patients. To increase the recruitment rate, Scandion Oncology is expanding the number of sites in Denmark from 2 to 5 and will further add additional sites in the EU.
Scandion Oncology A/S today announced that the company has obtained approval from the German regulatory authorities to initiate clinical trials in Germany with SCO-101 in the PANTAX Ib study.
Scandion Oncology A/S (“Scandion Oncology”) reports that the next evaluable colorectal cancer patient at the 8 weeks CT-scanning shows stable disease in the patients liver metastases, which are used to measure disease activity but a new metastatic lesion has appeared in the lung of the patient. According to the clinical protocol the patient will discontinue protocol treatment.
Scandion Oncology A/S (“Scandion Oncology”) reports on data from the first cohort of chemotherapy resistant colorectal cancer patients treated with SCO-101 and chemotherapy (FOLFIRI). All patients in the first cohort have now completed at least one treatment cycle (14 days). The main result is that 150 mg daily oral SCO-101 potentiates the effects of chemotherapy (FOLFIRI). Based on the safety data from this first cohort of patients, the Data Safety Monitoring Board has recommended to include 3 additional patients at 150 mg SCO-101 in order to get more details on the interactions between SCO-101 and FOLFIRI.
The current Phase II clinical study with SCO-101 is treating a serious diseases with no satisfactory treatment option and therefore Scandion Oncology has together with its clinical partners at the hospitals decided to continue the colorectal cancer study with FOLFIRI resistant patients. Due to the current situation related to the COVID-19 pandemic, Scandion Oncology is not able to predict how many patients that will be included in the next couple of months. Enrolment into the study will be solely based on the discretion of the clinical investigators.