Prexasertib has been on a more than two decade journey, and that doesn't include commercialization. In the drug’s latest chapter, Acrivon Therapeutics hopes to get the investigational cancer treatment across the regulatory finish line, and the biotech has picked up $100 million to do so.
The genetic signature signals deficiencies in a cellular process called the replication stress response (RSR). By studying 12 cohorts of patients with low-mutated tumors spanning seven cancer types, the MD Anderson team showed that the biomarker could predict response to PD-1/L1 checkpoint inhibitors. Inducing RSR defects improved survival in mice treated with checkpoint inhibitors, they reported in Science Translational Medicine.
Eli Lilly's top-launching new meds Trulicity and Taltz didn't deliver as expected in the first quarter, and executives faced a grilling Tuesday on what they plan to do about it.
A pair of Eli Lilly’s cancer prospects that made it through a pipeline cull in 2017 weren’t so lucky come 2019. The Big Pharma revealed in its first-quarter earnings presentation that it is dumping a PI3K/mTOR dual inhibitor it was developing for use in combinations and prexasertib, the CHK1 inhibitor it picked up from Array BioPharma.
Eli Lilly took a hit Tuesday morning as the pharma giant revealed just how painful its withdrawal of Lartruvo will be for its oncology operations while the Cialis franchise gets eaten up by generics. Less visible was a decision to dump two mid-stage drugs from its pipeline operations, both of which had figured prominently as one of its best longterm hopes in the field.