GLP-1 (glucagon-like peptide-1) receptor agonists make up a well-established class of treatment for Type 2 diabetes. AstraZeneca’s Byetta and Bydureon, Novo Nordisk’s Victoza and Ozempic, and Eli Lilly’s Trulicity all belong to this family. Because of their possible actions on nerve cells, scientists are now exploring the potential of GLP-1 receptor agonists in treating neurodegenerative diseases.
Peptron has developed a novel form of SR-exenatide that effectively crosses the blood-brain barrier and provides sustained release of the neuroprotective peptide
Peptron Inc. (087010:KS), a Korean-based public pharmaceutical company that focuses on peptide engineering and developing sustained-release medicine technology, announced today a new exclusive worldwide license of intellectual property from the National Institute on Aging, an institute or center of the National Institutes of Health (NIH), an agency of the United States Department of Health & Human Services. The exclusive license covers the delivery and use of sustained-release (SR) exenatide, a GLP-1 receptor agonist, in the treatment of neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. This intellectual property was developed as part of a Cooperative Research and Development Agreement (CRADA) between Peptron and the NIH to develop and advance a form of exenatide that effectively crosses the blood-brain barrier and provides sustained release of the neuroprotective peptide to treat degenerative diseases of the central nervous system (CNS).