After Pfizer launched Mylotarg, the first antibody drug conjugate (ADC) in 2000, it seemed to be the long-awaited “magic bullet” in cancer; it was a drug that would travel straight to tumors and drop a toxic payload inside of them. But despite the excitement and the promise, it took another 11 years for the next ADC (Seagen’s Adcetris) to arrive on the market.
Wyeth’s Mylotarg (Gemtuzumab Ozogamicin) Receives Supplemental Approval In US
Wyeth Pharm’s Mylotarg (Gemtuzumab Ozogamicin) Receives Supplemental Approval In US
NICE set to reject Pfizer's leukaemia drug Besponsa
Wyeth Pharm’s Inotuzumab Ozogamicin Receives Supplemental Approval In US
Pfizer Inc. (NYSE:PFE) today announced that a Biologics License Application (BLA) for inotuzumab ozogamicin has been accepted for filing and granted Priority Review by the U.S. Food and Drug Administration (FDA). Inotuzumab ozogamicin is being evaluated for the treatment of adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).
Pfizer's latest breakthrough-designated drug, which is also being looked at by the EMA in Europe, has seen its submissions based on the phase 3 INO-VATE 1022 trial, which looked at relapsed or refractory B-cell ALL and compared inotuzumab ozogamicin to standard-of-care chemo.
Of all the drugs being discussed at this year’s meeting of the American Society of Hematology, one caught my attention. The new agent, a monoclonal antibody to CD22 with a toxin attached, is manufactured by Pfizer. It’s called inotuzumab ozogamicin. As that’s a mouthful, some doctors call it Ino.
Pfizer has invested $46m in separate collaborations with four R&D companies specialising in developing ADCs, immuno-oncology candidates and gene-therapies.
Celator Pharmaceuticals, Inc. (Nasdaq: CPXX) today announced that CPX-351 (also known as VYXEOS™) has been selected for participation in a Cardiff University-sponsored clinical trial in adult patients with newly diagnosed acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS).