OncoSec Medical’s six-year pursuit of potentially pivotal data on its Keytruda combination has delivered a last-minute twist. After touting an 18.8% investigator-assessed response rate, the biotech has revealed that the final result per blinded independent central review (BICR) fell well short of the bar for success.
Another biotech is feeling the chill of the bear market, laying off staff in an effort to preserve cash.
Following a shake-up at the top, OncoSec Medical is now reducing its workforce by almost half as it tightens its focus on its lead melanoma trial of its only clinical-stage candidate.
OncoSec Medical announced it has entered into a Clinical Trial Collaboration and Supply Agreement with Merck (known as MSD outside the United States and Canada) to evaluate the combination of OncoSec's DNA-plasmid interleukin-12 (IL-12) Tavo (tavokinogene telseplasmid) with Merck's anti-PD-1 therapy, Keytruda (pembrolizumab), in a global phase 3 randomized clinical trial, KEYNOTE-C87. The planned clinical trial will evaluate the overall survival of patients treated with the Tavo in combination with Keytruda versus standard of care in late-stage patients with metastatic melanoma who are refractory to immune checkpoint therapy.
OncoSec Medical announced it has entered into a Clinical Trial Collaboration and Supply Agreement with Merck (known as MSD outside the United States and Canada) to evaluate the combination of OncoSec's DNA-plasmid interleukin-12 (IL-12) Tavo (tavokinogene telseplasmid) with Merck's anti-PD-1 therapy, Keytruda (pembrolizumab), in a global phase 3 randomized clinical trial, KEYNOTE-C87. The planned clinical trial will evaluate the overall survival of patients treated with the Tavo in combination with Keytruda versus standard of care in late-stage patients with metastatic melanoma who are refractory to immune checkpoint therapy.