Despite flourishing domestic excipient units, India still imports huge quantities of excipients from various countries. Nitika MD said “A number of pharma companies still feel that imported excipients are better than domestic excipients. It takes a lot of time to build trust among pharma units about new excipients. Low cost and high quality Indian excipients are in high demand by middle and small companies.”
This study assesses the solid-solid interactions between the commercial form of Ketoprofen (KET), a non- steroidal anti-inflammatory drug of the propionic acid class, and several widely used pharmaceutical excipients. The work was carried out on drug-excipient mixtures, in 1:1 (w:w) ratio, blended in an agate mortar at room temperature. The compatibility/incompatibility of KET with the proposed excipients was highlighted by the most commonly used analytic methods: differential scanning calorimetry (DSC), Fourier transformed infrared spectroscopy (FT-IR) and powder X-ray diffraction (PXRD). The interactions between KET and three of the excipients, namely Macrogol 6000, magnesium stearate dehydrate and lactose monohydrate were evidenced by DSC and further confirmed by FT-IR and PXRD analysis.
The Story of Magnesium Stearate as a Powder and a Tablet Lubricant