Retrophin, based in San Diego, announced that the U.S. Food and Drug Administration (FDA) had given its 100 mg and 300 mg tablets of Thiola EC (tiopronin) the thumbs-up to treat cystinuria. Cystinuria is a rare inherited disease that results in a buildup of cystine levels in the urine, causing the development of recurring cystine kidney stones.
According to a recent FDA Enforcement Report, Sandoz on Nov. 9 began recalling 19 lots of L-Cysteine Hydrochloride Injection, which is used to meet the amino acid nutritional requirements of infants receiving total parenteral nutrition. Sandoz in an email today said the recalled product had been produced for it by Allergy Labs at its facility in Oklahoma City, but that Sandoz no longer distributes that product.
Doxepin is a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa. Doxepin is one approach in treating insomnia and depression in Parkinson's disease. Patients with Parkinson's disease suffer difficulties in swallowing. Therefore, it was the aim of this study to develop a buccal-adhesive delivery system. Methods: Pectin was modified with cysteine. Stability assays in form of disintegration assay according to the Ph.Eur were performed. Furthermore, bioadhesiveness on buccal mucosa was investigated incorporating the drug doxepin. Results: The adhesiveness was improved 1.4-fold and revealed a sustained release over 3 h. Conclusion: Taking these findings into account, the modifications render this designed excipient fruitful for buccal delivery.
Compounding pharmacy Imprimis Pharmaceuticals Inc said on Wednesday it plans to make a cheaper alternative to Retrophin Inc's kidney stone drug, Thiola.nnRetrophin, under former Chief Executive Martin Shkreli, raised the price of the drug from $1.50 to $30 per tablet after buying the rights from Mission Pharmacal Co in 2014, Imprimis said.
Smart polymer nanogel-assisted drug delivery systems have attracted more and more attention in cancer chemotherapy because of their well-defined morphologies and pleiotropic functions in recent years. In this work, an L-cystine-crosslinked reduction-responsive polypeptide nanogel of methoxy poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine) (mPEG-P(LP-co-LC)) was employed as a smart excipient for RM-1 prostate cancer (PCa) chemotherapy. Doxorubicin (DOX), as a regular chemotherapy drug, was embedded in the nanogel. The loading nano gel marked as NG/DOX was shown to exhibit glutathione (GSH)-induced swelling and GSH-accelerated DOX release. Subsequently, NG/DOX showed efficient cellular uptake and proliferation inhibition. Furthermore, NG/DOX presented enhanced antitumor efficacy and security in an RM-1 PCa-grafted mouse model in vivo, indicating its great potential for clinical
A new copper-based biological nanomaterial discovered and assembled at Louisiana Tech University interacts with cells in the body and could ultimately be used as a targeted delivery tool to treat cancer and other diseases.
Drug shortages become issue in Teva and Mylan hook-up
Walgreens Infusion Services, Ongoing Class II recall of L-cysteine various strengths because of Lack of sterility assurance.