KSQ Therapeutics and CTMC Announce Strategic Collaboration to Accelerate the Development of Novel Engineered Tumor Infiltrating Lymphocyte (eTIL®) Therapies for the Treatment of Solid Tumors
Roche is pushing deeper into synthetic lethality. One year after paying $125 million to join the ATR race, the Swiss drug developer has secured an exclusive global license to KSQ Therapeutics’ early-phase USP1 inhibitor.
Takeda has doubled down on KSQ Therapeutics, handing over “double-digit millions of dollars” on day one and committing up to $510 million on the back end to research and validate novel tumor-intrinsic targets.
LEXINGTON, Mass.--(BUSINESS WIRE)--KSQ Therapeutics, a clinical-stage biotechnology company developing therapies to treat cancer and autoimmune diseases using its proprietary, integrated discovery CRISPRomics platform, announced today that Ono Pharmaceutical Co., Ltd. (“ONO”), has acquired multiple research-stage DNA damage response (DDR) programs identified using KSQ’s CRISPRomics platform technology. All the programs are novel and have the potential to become first-in-class therapies.
KSQ Appoints Mahesh Karande to its Board of Directors
KSQ Therapeutics Announces First Patient Dosed in Combination Portion of the Ongoing Phase 1 Study of KSQ-4279, a First-In-Class USP1 Inhibitor, in Patients with Advanced Solid Tumors
LEXINGTON, Mass.--(BUSINESS WIRE)--KSQ Therapeutics, a clinical-stage biotechnology company developing therapies to treat cancer and autoimmune diseases using its proprietary, integrated discovery CRISPRomics® platform, today named Micah Benson, PhD as the new Chief Scientific Officer (CSO) and announced the addition of a new Chief Technology Officer (CTO), Tom Leitch, to the KSQ leadership team. Dr. Benson previously served as Senior Vice President, Immunobiology for KSQ and has been a catalyst for the company’s adaptive cell therapy programs. He will succeed Frank Stegmeier, PhD, who served as KSQ's founding CSO, who is leaving to pursue a new opportunity. Dr. Stegmeier will join KSQ's Board of Directors. Board member Pearl Huang, PhD, is stepping down from the board.
CAMBRIDGE, Mass.--(BUSINESS WIRE)--KSQ Therapeutics (KSQ), a clinical-stage biotechnology company developing therapies to treat cancer and autoimmune diseases using its proprietary, integrated discovery CRISPRomics® platform, will give an oral presentation as part of the “New Drugs on the Horizon: Part 1” session at the upcoming American Association for Cancer Research (AACR) 2022 Annual Meeting in New Orleans. The company will provide an overview of preclinical data on its first-in-class USP1 inhibitor, KSQ-4279, which supports the ongoing Phase 1 clinical trial of KSQ-4279 being conducted in patients with advanced solid tumors.
CAMBRIDGE, Mass.--(BUSINESS WIRE)--KSQ Therapeutics, a biotechnology company developing drugs to treat cancer and autoimmune diseases using its proprietary, integrated discovery platform to systematically screen the whole genome in cancer and immune cells, today announced the initiation of dosing in a Phase 1 clinical study of KSQ-4279, a first-in-class USP1 inhibitor, in patients with advanced solid tumors.
The potential applications for CRISPR/Cas9 continue to grow as drugmakers look for novel ways to use the powerful gene editing platform to rework drug discovery and development. Japanese drugmaker Takeda has dabbled on the gene editing front, and now it’s pairing up with a biotech using CRISPR screening to laser in on oncology candidates.