NIJMEGEN, Netherlands, Nov. 1, 2023 /PRNewswire/ -- Khondrion, a clinical stage biopharmaceutical company discovering and developing therapies targeting primary mitochondrial diseases, today announced that the United States Patent and Trademark Office and the European Patent Office have granted patents covering the use of Khondrion's lead compound sonlicromanol as an [mPGES-1 inhibiting] anti-inflammatory agent.
Khondrion announces sonlicromanol Phase IIb progress supporting Phase III development in MELAS spectrum disorders Sonlicromanol for MELAS spectrum disorders – a rare, progressive primary...
Khondrion’s mitochondrial disease candidate has missed the mark in a phase 2b clinical trial. But the Dutch biotech, clutching post hoc analyses and long-term follow-up data, plans to advance into the next stage of development anyway in the belief the totality of the evidence supports further work.
NIJMEGEN, the Netherlands – 10 January 2022: Khondrion, a clinical stage biopharmaceutical company discovering and developing therapies targeting primary mitochondrial diseases, today announced that the last patient has been dosed with sonlicromanol in the KHENERGYZE Phase IIb clinical study. Sonlicromanol is Khondrion’s wholly-owned, lead asset being developed to treat a range of mitochondrial diseases in children and adults. Topline data from KHENERGYZE is expected in the third quarter of 2022.
Khondrion moves headquarters to Novio Tech Campus to support growth
NIJMEGEN, the Netherlands – 21 April 2021: Khondrion, a clinical-stage biopharmaceutical company discovering and developing therapies targeting mitochondrial disease, today announces that the first patients have been successfully dosed in its KHENERGYC paediatric Phase II study (NCT04846036) to explore the pharmacokinetics, safety and efficacy of sonlicromanol in children with a genetically confirmed primary mitochondrial disease and suffering from motor symptoms.
Khondrion, the clinical-stage pharmaceutical company discovering and developing therapies targeting mitochondrial disease, starts 2019 with the launch of its new website.
NIJMEGEN, the Netherlands – 18 January, 2021: Khondrion, a clinical-stage biopharmaceutical company discovering and developing therapies targeting mitochondrial disease, today announces that the European Medicines Agency (EMA) has accepted its Paediatric Investigation Plan (PIP) for the development of its wholly-owned lead asset, sonlicromanol, for children.
NIJMEGEN, the Netherlands – 13 January 2021: Khondrion, a clinical-stage biopharmaceutical company discovering and developing therapies targeting mitochondrial disease, today announces the publication of the mode of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE2 by sonlicromanol’s in vivo active metabolite KH176m, in the leading peer reviewed Nature journal, Scientific Reports.
NIJMEGEN, the Netherlands – Monday, November 30, 2020: Khondrion, a clinical-stage biopharmaceutical company discovering and developing therapies targeting mitochondrial disease, today announces that the Company will provide a development overview of its Phase 2B clinical-stage drug sonlicromanol in a poster lightning talk session at the Mitochondrial Medicine 2020 virtual conference, being held from November 30 to December 2, 2020.