OEGSTGEEST, The Netherlands, Dec. 12, 2023 /PRNewswire/ -- ISA Pharmaceuticals B.V. (ISA), a clinical-stage immunotherapy company, today announced positive anti-tumor response data with ISA101b, an HPV16 directed therapeutic cancer vaccine given in combination with Libtayo®, an anti-PD1 checkpoint inhibitor (CPI). The data were generated in the OpcemISA trial, a large scale randomized double blind study that is ongoing in patients with advanced oropharyngeal cancer (OPC), a type of head and neck cancer. It is the first time that the combination of a tumor-specific therapeutic vaccine and a CPI has generated such high response rates, albeit in a predefined subpopulation of metastatic cancer patients.
ISA Pharmaceuticals' cancer vaccine may have failed to improve the overall response rate in a phase 2 trial, but the Netherlands-based biotech is insistent that honing in on a subgroup of patients that it hopes will reap rewards in phase 3.
OEGSTGEEST, Netherlands, Aug. 31, 2023 /PRNewswire/ -- ISA Pharmaceuticals B.V., a clinical-stage biotech company developing immunotherapies to treat cancers and serious infectious diseases, is pleased to announce that the first patient has been dosed in the HEB-PEP study. This first-in-human (FIH) phase 1 study investigates the use of ISA104, a novel treatment aimed to establish functional cure in Chronic Hepatitis B patients. Dosing took place at the Liver Unit of the Erasmus Medical Center in Rotterdam, the sponsor of this dose escalation study.
ISA Pharmaceuticals has announced that the first patient has been dosed in its phase 1 HEB-PEP study, assessing the use of ISA104 for the treatment of patients with chronic hepatitis B. This is a first-in-human trial assessing the novel treatment with the intention of finding a functional cure for this indication.
OEGSTGEEST, The Netherlands, June 6, 2023 /PRNewswire/ -- ISA Pharmaceuticals B.V., a clinical-stage biotechnology company developing immunotherapies to treat cancers and serious infectious diseases, presented the first clinical data of the combination of ISA101b (peltopepimut-S) and Regeneron's anti-PD-1 Libtayo® (cemiplimab) at the ASCO annual meeting in Chicago.
OEGSTGEEST, Netherlands, May 25, 2023 /PRNewswire/ -- ISA Pharmaceuticals B.V., a clinical-stage biotechnology company developing immunotherapies to treat cancers and serious infectious diseases, today announces that it will present the first clinical data of the combination of ISA101b and Regeneron's PD-1 inhibitor Libtayo® (cemiplimab) in patients with recurrent metastatic Human Papilloma Virus type 16 (HPV16) induced head and neck cancers who progressed on pembrolizumab or nivolumab.
ISA Pharmaceuticals to Present Pre-clinical Data on its Protective SLP Therapy Against SARS-CoV-2 at the CIMT Annual Meeting
OEGSTGEEST, Netherlands, April 20, 2023 /PRNewswire/ -- ISA Pharmaceuticals, B.V., a clinical stage biotech company developing immunotherapies to treat cancers and infectious diseases, is pleased to announce that it will be participating and presenting in person, at the following scientific and business conferences in May and June of 2023.
OEGSTGEEST, Netherlands and HOUSTON, Jan. 4, 2023 /PRNewswire/ -- ISA Pharmaceuticals, B.V., a clinical stage biotech company developing immunotherapies to treat cancers and infectious diseases, and Cancer Focus Fund, LP, a unique investment fund established in collaboration with The University of Texas MD Anderson Cancer Center to provide funding and clinical expertise to advance promising cancer therapies, today announced that Cancer Focus Fund is investing $5 million in funding to support ISA103, ISA's PRAME-targeting immunotherapy, in a first-in-human study for the treatment of uveal melanoma, a rare ocular cancer.
ISA Pharmaceuticals has completed participant enrolment in the Phase II OpcemISA clinical trial of ISA101b in Human Papilloma Virus type 16 (HPV16) induced oropharyngeal cancer (OPC).