NEWPORT BEACH, Calif.--(BUSINESS WIRE)--ImmunogenX is pleased to report the successful completion of the CeliacShield™ trial (NCT03585478), focused on treating celiac disease (CeD) patients, will be published in the premier journal Gastroenterology and is entitled:
WALTHAM, Mass.--(BUSINESS WIRE)--May 19, 2021-- ImmunoGen Inc. (Nasdaq: IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, today announced mature data from the FORWARD II study evaluating mirvetuximab soravtansine in combination with Avastin® (bevacizumab) in patients with medium and high folate receptor alpha (FR?)-expressing recurrent ovarian cancer for whom a non-platinum based combination regimen is appropriate. These findings will be highlighted in an oral presentation at the 2021 American Society of Clinical Oncology (ASCO) Virtual Annual Meeting, which is being held June 4-8, 2021. Two posters highlighting mirvetuximab combination regimens will also be presented by ImmunoGen’s collaborators during the meeting.
NEWPORT BEACH, Calif.--(BUSINESS WIRE)--ImmunogenX is happy to announce the successful completion of the CeliacShield™ trial (NCT03585478). This gluten-challenge trial measured several outcomes including histology, symptoms, serology, and gluten in urine. The trial also incorporated our CypCel diagnostic technology as a monitor of small intestinal villous health utilizing the drug biomarker simvastatin as measured in blood samples. Histologic protection was assessed by measuring changes in villous height to crypt death ratio (?Vh:Cd) and intraepithelial lymphocytes (?IEL) before and after a 6-week, 2g per day gluten challenge period. The attenuation of ?Vh:Cd and ?IEL for the active (1200-mg latiglutenase) group relative to placebo was 82% and 60% with p-values of 0.0758 and 0.0181 (ANCOVA), respectively. Measurements of gluten immunogenic peptides in urine showed reduction of gluten of 77% for latiglutenase vs. placebo with p = 0.0009 (unpaired, 2-tailed t-test). Symptom attenuation was 93% (abdominal pain), 53% (bloating) and 99% (tiredness) with a 3 x 2-week trend-line significance of p = 0.0142, 0.0298 and 0.0018 (unpaired, 2-tailed t-test), respectively. Serology measurements for TTG-IgA, DGP-IgG and DGP-IgG all showed worsening for placebo and improvement for latiglutenase groups relative to baseline.
NEWPORT BEACH, Calif.--(BUSINESS WIRE)--ImmunogenX is happy to announce the successful completion of the CeliacShield™ trial (NCT03585478). This gluten-challenge trial measured several outcomes including histology, symptoms, serology, and gluten in urine. The trial also incorporated our CypCel diagnostic technology as a monitor of small intestinal villous health utilizing the drug biomarker simvastatin as measured in blood samples. Histologic protection was assessed by measuring changes in villous height to crypt death ratio (?Vh:Cd) and intraepithelial lymphocytes (?IEL) before and after a 6-week, 2g per day gluten challenge period. The attenuation of ?Vh:Cd and ?IEL for the active (1200-mg latiglutenase) group relative to placebo was 82% and 60% with p-values of 0.0758 and 0.0181 (ANCOVA), respectively. Measurements of gluten immunogenic peptides in urine showed reduction of gluten of 77% for latiglutenase vs. placebo with p = 0.0009 (unpaired, 2-tailed t-test). Symptom attenuation was 93% (abdominal pain), 53% (bloating) and 99% (tiredness) with a 3 x 2-week trend-line significance of p = 0.0142, 0.0298 and 0.0018 (unpaired, 2-tailed t-test), respectively. Serology measurements for TTG-IgA, DGP-IgG and DGP-IgG all showed worsening for placebo and improvement for latiglutenase groups relative to baseline.