MANHASSET, N.Y.--(BUSINESS WIRE)--One of the main roles of the spleen is to help the body’s immune system fight infections. The spleen does this through producing and regulating antibodies – antibody production is negatively affected in various conditions, including sepsis and autoimmune diseases like lupus. New research published in Science Advances by The Feinstein Institutes for Medical Research scientists shows that activation of the vagus nerve triggers the spleen, thereby regulating the production of antibodies. This research highlights how the nervous system regulates immunity and suggests potential for non-pharmalogical, vagus nerve modulation to treat a variety of diseases, like lupus and sepsis.
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MANHASSET, N.Y.--(BUSINESS WIRE)--Sepsis affects at least 1.7 million Americans annually, causing the death of 270,000 patients and 30 percent of all hospital deaths. To better understand the molecular mechanisms of sepsis to develop treatments, The Feinstein Institutes for Medical Research has been awarded a five-year, $2.5 million grant from the National Institutes of Health (NIH).
Researchers at Montefiore Health System and Albert Einstein College of Medicine in the US have started a clinical trial to assess antiviral drug remdesivir plus rheumatoid arthritis medication baricitinib to treat hospitalised patients with severe Covid-19.