SAN FRANCISCO, May 18, 2020 /PRNewswire/ -- The article describes the evaluation of dutogliptin in healthy volunteers that preceded Recardio's ongoing Phase 2 safety and efficacy study in patients who experience a severe heart attack. It established the safety, tolerability, and dosing regimen required for subcutaneously administered dutogliptin to effectively inhibit dipeptidyl peptidase 4 (DPP-IV). Pre-clinical research suggests that inhibition of DPP-IV may improve homing of G-CSF mobilized stem cells and improve healing at the site of injury and cardiac function following a heart attack.
Medical research group Recardio has reportedly halted a trial of an experimental heart drug because of uncertainties surrounding the UK’s departure from the European Union.