Enforcement Report - Week of November 7, 2018
The polymorphism of D-Mannitol (mannitol) is reviewed in this paper. It was found that the structure of the stable form is consistent in most literatures, but different authors have given different information about the two metastable forms. Therefore the commonly used nomenclature of mannitol was summarized based on the crystal unit cell parameters with the help of X-ray powder diffraction. Moreover, the crystal growth mechanism of mannitol polymorphs was summarized. Considering the lack of kinetic data for the metastable form especially, a reported method was attempted to apply to ? mannitol in an aqueous cooling crystallization process based on the induction time previously measured, and it was identified that the growth of the ? form follows the two-dimensional (2D) nucleation-mediated mechanism. The results also indicates that the method based on induction time and supersaturation should have the potential to be expanded to the metastable polymorphs for the growth property study in a bulk system.
This report analyzes and forecasts the market for excipients at the global and regional level. The market has been forecast based on volume (tons) and revenue (US$ Thousand) from 2015 to 2023. The study includes drivers and restraints of the global excipients market. It also covers the impact of these drivers and restraints on demand for excipients during the forecast period. The report also highlights opportunities in the excipients market at the global and regional level.
In the present study an attempt has been made to evaluate Ocimum bascilium mucilage coprocessed with Mannitol as a novel super disintegrant. Coprocessed excipients were prepared by solvent evaporation method and evaluated in the formulation of mouth dissolving tablets of Terbutaline sulphate.
A new formulation has been developed successfully, which includes production of highly-porous mannitol particles with high surface areas through the spray drying of mannitol solutions containing
The principle of carrier-based blends is well established in formulations for dry powder inhalation, as it overcomes problems of micronized drug particles often being cohesive and poorly flowable and hence, creating difficulties in powder handling and dosing.1 In carrier-based blends, micronized drug is adhered on the surface of the carrier and thus, is moved and dosed as if it were a larger particle. For nasal administration, particles larger than 10 ?m, probably
Mannitol is a frequently used diluent in the production of tablets due to its non-hygroscopic character and low drug interaction potential. Although the ?-polymorph of mannitol has superior tabletability in comparison to ?- and ?-mannitol, the latter are most commonly used because large-scale production of ?-mannitol is difficult. Therefore, a continuous method for production of ?-mannitol was developed in the current study. Spray drying an aqueous solution of mannitol and PVP in a ratio of 4:1 resulted in formation of ?-mannitol. The tabletability of a physical mixture of spray dried ?-mannitol with PVP (5%) and paracetamol (75%) was clearly superior to the tabletability of physical mixtures consisting of spray dried ?- and ?-mannitol with PVP (5%) and paracetamol (75%) which confirmed the excellent tableting properties of the ?-polymorph.