Two years since Novo Nordisk made a push into the ribonucleic acid space spearheaded by its acquisition of Dicerna Pharmaceuticals, the Danish drugmaker has announced a new collaboration to find ways to fine-tune RNA tech.
LEXINGTON, Mass.--(BUSINESS WIRE)--Novo Nordisk today announced that the acquisition of Dicerna Pharmaceuticals, Inc. (Dicerna; Nasdaq: DRNA), announced on 18 November 2021, has been completed.
LEXINGTON, Mass.--(BUSINESS WIRE)--Dicerna Pharmaceuticals, Inc. (Nasdaq: DRNA) today announced that the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended (“HSR”), in connection with Novo Nordisk’s cash tender offer for Dicerna expired at 11:59 p.m., Eastern Time, on December 24, 2021.
Mike Macaluso will be taking a one-year medical leave of absence from his duties as chairman and CEO of Englewood, CO-based Ampio Pharmaceuticals after disclosing last month that he is undergoing treatment. Michael Martino took a seat at the board of directors at the time of that October announcement, and the company will now be entrusted to him as interim chairman and CEO while Macaluso is away. Ampio also revealed a month ago that COO Holli Cherevka was elevated to president and COO, while Howard Levy — a CSL Behring and Novo Nordisk vet who retired from Catalyst Biosciences this summer — was named CMO. Dicerna chairman Kevin Buchi has also been added to Ampio’s board of directors.
Alnylam Pharmaceuticals is a prime potential buyout target for Novartis, Bloomberg reported, citing people with knowledge of the matter.
Lars Fruergaard Jørgensen has landed the major takeover he has targeted since taking over as CEO of Novo Nordisk. Having missed out on Ablynx to Sanofi in 2018, Novo Nordisk has agreed to a $3.3 billion buyout of its RNAi partner Dicerna Pharmaceuticals as part of its search for new growth drivers.
LEXINGTON, Mass.--(BUSINESS WIRE)--Dicerna Pharmaceuticals, Inc. (Nasdaq: DRNA), a leading developer of investigational ribonucleic acid interference (RNAi) therapeutics, today presented results from its Phase 1 double-blind, placebo-controlled, randomized trial of belcesiran, an investigational GalXC™ RNAi therapeutic in development for the treatment of alpha-1 antitrypsin (AAT) deficiency-associated liver disease (AATLD). These data expand upon interim results announced in July 2021, demonstrating the safety and tolerability of single ascending doses of belcesiran in healthy volunteers (up to and including the final 12 mg/kg dose cohort) and further reaffirming the dosing regimen established for the ESTRELLA Phase 2 study of belcesiran. In addition, the data demonstrated robust, dose?dependent reductions in serum AAT through the 6 mg/kg dose level, with a maximum individual reduction of 91%. The data were presented in a poster at The Liver Meeting® 2021, the annual meeting of the American Association for the Study of Liver Diseases (AASLD).
Dicerna is no longer looking to move from being a clinical- to a commercial-stage biotech.
LEXINGTON, Mass.--(BUSINESS WIRE)--Dicerna Pharmaceuticals, Inc. (Nasdaq: DRNA) (the “Company” or “Dicerna”), a leading developer of investigational ribonucleic acid interference (RNAi) therapeutics, today announced the U.S. Food and Drug Administration (“FDA”) acceptance of the Investigational New Drug (“IND”) application filed by Eli Lilly and Company (“Lilly”) for LY3819469, the second clinical-stage candidate to emerge from Dicerna’s collaboration with Lilly. The IND milestone triggers a $10 million payment to Dicerna and enables Lilly to initiate a Phase 1 clinical trial of LY3819469, an investigational GalXC™ RNAi candidate targeting the LPA gene as a potential treatment of cardiometabolic diseases.
LEXINGTON, Mass.--(BUSINESS WIRE)--Dicerna Pharmaceuticals, Inc. (Nasdaq: DRNA), a leading developer of investigational ribonucleic acid interference (RNAi) therapeutics, today reported its financial results for the third quarter ended September 30, 2021 and provided a business update.