Areteia Therapeutics Announces Additional $75MM in Series A Financing
Areteia Therapeutics Announces Publication of Phase II Data of Oral Dexpramipexole in Eosinophilic Asthma
Areteia Therapeutics Announces Start of Phase III Clinical Trials of Oral Dexpramipexole in Eosinophilic Asthma
Bain Capital Life Sciences is at it again. Biotech’s go-to source for big-ticket financing rounds has stepped up to lead a $350 million series A round in Areteia Therapeutics, positioning the newly created startup to run phase 3 trials of an asthma candidate designed to have biologiclike efficacy in an oral dosage form.
PITTSBURGH--(BUSINESS WIRE)--Knopp Biosciences LLC today reported further clinical data from its Phase 2 Exhale trial demonstrating oral dexpramipexole improves airflow obstruction in asthma as measured by FEV1, largely through its effect on FVC. Change in FVC was the dominant contributor to increases in FEV1, which suggests that by lowering eosinophils in the airway lumen, dexpramipexole may act to decrease mucus plugging and air trapping in small airways. As previously reported, dexpramipexole produced clinically meaningful increases in FEV1 across study arms and time points.
Knopp Biosciences LLC today announced positive top-line results in a Phase 2 dose-ranging trial of the novel oral drug dexpramipexole in patients with moderate-to-severe eosinophilic asthma.
Knopp Biosciences LLC today reported further clinical and biomarker data demonstrating that reduction in eosinophil count by oral dexpramipexole significantly correlated with improved lung function in the positive Phase 2 EXHALE trial of dexpramipexole in patients with moderate-to-severe eosinophilic asthma. The data were presented in a late-breaking abstract session at the European Respiratory Society International Congress 2021.
PITTSBURGH--(BUSINESS WIRE)--Knopp Biosciences LLC gab heute positive Ergebnisse einer Phase-2-Dosisfindungsstudie mit dem neuartigen oral verabreichten Medikament Dexpramipexol bei Patienten mit mittelschwerem bis schwerem eosinophilem Asthma bekannt.
PITTSBURGH, Sept. 16, 2020 (GLOBE NEWSWIRE) --Â Knopp Biosciences LLCÂ today announced the completion of enrollment in a Phase 2 trial of the oral small-molecule dexpramipexole in patients with moderate-to-severe eosinophilic asthma.
It’s no secret: Amyotrophic lateral sclerosis (ALS) is a tough nut to crack. And no one knows that better than Biogen, which in 2013 saw its last ALS effort, dexpramipexole, go up in flames in phase 3.