IRVING, Texas--(BUSINESS WIRE)--Arugula Sciences announced today that it has received clearance from the FDA for its investigational new drug (IND) application for a Phase 1, open-label, dose-ranging clinical trial of SIG002, a perinatal-derived secretome product. This trial will assess the safety, tolerability, preliminary efficacy, and dose effect of SIG002 in patients with symptomatic osteoarthritis of the first metatarsophalangeal joint.