BELLEVUE, WA / ACCESSWIRE / June 10, 2021 / Allysta Pharmaceuticals, Inc. (Allysta) today announced dosing of the first subject in its Phase 1 trial (ALY688-SR-101) of ALY688-SR, a synthetic peptide with sustained release properties that induces adiponectin-related signaling pathways. Adiponectin is a major cytokine produced by adipose tissues that plays a key protective role in reducing the adverse effects of caloric excess. Adiponectin and ALY688-SR have been shown to reduce insulin resistance, improve lipid metabolism, and decrease inflammation and fibrosis in a range of animal models. There is evidence that increasing adiponectin levels, which are low in obesity-related conditions such as metabolic syndrome, Type 2 diabetes, and fatty liver disease, may prevent or reduce the damage associated with chronic caloric excess. ALY688-SR is being developed for obesity-associated indications including non-alcoholic steatohepatitis (NASH), cardiac remodeling associated with metabolic dysfunction such as heart failure with preserved ejection fraction (HFpEF), and others.
SAN MATEO, CA / ACCESSWIRE / January 8, 2020 / Allysta Pharmaceuticals, Inc. (Allysta) today announced dosing of the first patient in its Phase 1/2a trial (ALY688-201) of ALY688 Ophthalmic Solution for the treatment of dry eye disease. Dry eye is a very common condition affecting millions of people in the US and causes eye symptoms (e.g., burning, foreign body sensation, pain) which can limit daily activities such as computer use, reading and driving. In advanced cases, significant inflammation and even scarring of the eye surface can occur.
SAN MATEO, CA / ACCESSWIRE / January 8, 2020 / Allysta Pharmaceuticals, Inc. (Allysta) today announced dosing of the first patient in its Phase 1/2a trial (ALY688-201) of ALY688 Ophthalmic Solution for the treatment of dry eye disease. Dry eye is a very common condition affecting millions of people in the US and causes eye symptoms (e.g., burning, foreign body sensation, pain) which can limit daily activities such as computer use, reading and driving. In advanced cases, significant inflammation and even scarring of the eye surface can occur.
SAN MATEO, CA / ACCESSWIRE / January 8, 2020 / Allysta Pharmaceuticals, Inc. (Allysta) today announced dosing of the first patient in its Phase 1/2a trial (ALY688-201) of ALY688 Ophthalmic Solution for the treatment of dry eye disease. Dry eye is a very common condition affecting millions of people in the US and causes eye symptoms (e.g., burning, foreign body sensation, pain) which can limit daily activities such as computer use, reading and driving. In advanced cases, significant inflammation and even scarring of the eye surface can occur.