AFYX Therapeutics (“AFYX”), a clinical-stage biopharmaceutical company developing innovative approaches to treat mucosal diseases, announced results from a preclinical study from the company’s collaboration with the University of Sheffield in the UK exploring the potential effects of delivering antibody fragments directly to inflamed tissue in mucosal diseases using Rivelin® technology. The preclinical study demonstrated for the first time that the company’s Rivelin technology is capable of delivering biologic drugs. The study showed that a) the company’s proprietary Rivelin patch was formulated with therapeutic anti-TNF? antibody fragments, b) those fragments were successfully delivered directly to inflamed mucosal tissue, and c) that the antibodies maintained a neutralizing effect on inflammatory cells. These data were presented by investigators from the University of Sheffield at the BioMedEng21 Annual Conference.
Qlaris Bio announced the enrollment of the first patient in the phase 1/2 clinical program for QLS-101, an investigational therapy designed to lower IOP by reducing episcleral venous pressure (EVP) in individuals with glaucoma.
SAN DIEGO & COPENHAGEN--(BUSINESS WIRE)--AFYX Therapeutics (“AFYX”), a clinical-stage biopharmaceutical company developing innovative approaches to treat mucosal diseases, today announced Phase 2 clinical efficacy and safety data of Rivelin® Clobetasol (“Rivelin-CLO”), a novel mucoadhesive patch designed to deliver clobetasol to lesions on wet tissue surfaces for the treatment of oral lichen planus (OLP). In this Phase 2 study investigating Rivelin-CLO across more than 20 clinical trial sites, a 20-µg dose resulted in a clinically significant reduction in OLP ulcer size, improvements in symptoms and quality of life, and a favorable safety profile compared to placebo – demonstrating its potential to address a significant unmet need in OLP. These data were presented during an oral session at the 2021 American Academy of Oral Medicine (AAOM) Virtual Annual Conference.