HENNIGSDORF and BERLIN, GERMANY / ACCESSWIRE / April 11, 2022 / 4TEEN4 pharmaceuticals GmbH announces today that its biomarker DPP3 will be used in a biomarker-guided trial in severe COVID-19 as communicated by the University Hospital Hamburg-Eppendorf (UKE) and SphingoTec GmbH. The study will be using two biomarkers, bioactive adrenomedullin (bio-ADM) and dipeptidyl peptidase 3 (DPP3), for patient stratification and inclusion criteria for the use of Adrecizumab (1). This revolutionary approach could serve as a precision medicine strategy in patients with severe COVID 19 infection.
Adrenomed AG, a German privately financed clinical-stage biopharmaceutical company, announced that it has received positive feedback from the European Medicines Agency (EMA) regarding the clinical development programme for its lead product candidate, Adrecizumab (INN: enibarcimab). The first-in-class antibody targets the vasoprotective peptide adrenomedullin to restore vascular integrity in patients with early septic shock, a life-threatening condition with very limited treatment options.
Adrenomed AG, the vascular integrity company, today reported positive top-line results from its proof-of-concept AdrenOSS-2 Phase II trial. AdrenOSS-2 evaluated the safety, tolerability and efficacy of Adrecizumab, a first-in-class monoclonal antibody targeting the vasoprotective peptide Adrenomedullin to restore and maintain vascular integrity in patients with early septic shock. Septic shock is a life-threatening condition with very limited treatment options. Sepsis is the main cause of death in hospitals worldwide.2