SAN DIEGO--(BUSINESS WIRE)--LENZ Therapeutics, a privately held late-stage clinical company, today reported positive topline results from its Phase 2 INSIGHT clinical trial of two investigational formulations of aceclidine to treat presbyopia. Both LNZ100 (aceclidine), and LNZ101 (aceclidine + brimonidine) achieved the primary endpoint of three-line or greater improvement in near visual acuity, without losing one-line or more in distance visual acuity at one hour, 71% and 56% of treated subjects respectively, compared to 6% of vehicle-treated. Both LNZ100 and LNZ101 maintained statistical significance of three-line or greater improvement compared to vehicle for all timepoints including the last measured at 10 hours, 37% and 48% respectively. Both formulations maintained an average pupil size of 1.5-2mm for 10 hours which is a biomarker of efficacy. Additionally, patient feedback indicated both formulations were well-tolerated and there were no serious drug related adverse events. Based on these positive outcomes, the company plans to initiate Phase 3 trials shortly.