LEXINGTON, Mass., April 8, 2024 /PRNewswire/ -- Accent Therapeutics, a biopharmaceutical company pioneering a novel class of small molecule precision cancer therapeutics presents advances in cancer targeting, including data on DHX9 and KIF18A inhibitor activity in multiple tumor types, at the 2024 American Association for Cancer Research (AACR) Annual Meeting, taking place April 5-10 in San Diego, California.
LEXINGTON, Mass., March 21, 2024 /PRNewswire/ -- Accent Therapeutics, a biopharmaceutical company pioneering a new class of small molecule precision cancer therapies, today announced four upcoming presentations and posters at the 2024 American Association for Cancer Research (AACR) Annual Meeting, taking place April 5-10 in San Diego, California.
LEXINGTON, Mass., Jan. 23, 2024 /PRNewswire/ -- Accent Therapeutics, a biopharmaceutical company pioneering a new class of small molecule precision cancer therapies, today announced the completion of a $75 million Series C financing. The financing was led by Mirae Asset Capital Life Science, with participation from other new investors, Mirae Asset Capital, Mirae Asset Venture Investment, Bristol Myers Squibb and Johnson & Johnson Innovation – JJDC, Inc., as well as all existing investors, including The Column Group, Atlas Venture, Droia Ventures, GV, EcoR1 Capital, AbbVie Ventures, The Mark Foundation for Cancer Research, Timefolio Capital (formerly known as NS Investment) and others. In conjunction with the financing, Naveen Krishnan, MD, MPhil, Managing Director of Mirae Asset Capital Life Science will join the Company's Board of Directors.
Accent Therapeutics has reeled in investments from two more pharmaceutical companies as part of a $75M series C, the latest validation for the RNA drug developer.
LEXINGTON, Mass., Oct. 10, 2023 /PRNewswire/ -- Accent Therapeutics, a biopharmaceutical company pioneering a new class of small molecule precision cancer therapies, today announced it will present data unveiling a novel, previously undisclosed program in two poster presentations at the 35th AACR-NCI-EORTC Symposium held October 11-15, 2023 in Boston, Massachusetts. The company will also present data supporting development of its ADAR1 and DHX9 programs in two additional poster presentations.
LEXINGTON, Mass., Sept. 21, 2023 /PRNewswire/ -- Accent Therapeutics, a biopharmaceutical company pioneering a new class of small molecule precision cancer therapies, today announced the appointments of Jason Sager, M.D., as Chief Medical Officer, Steven Mennen, Ph.D., as Vice President of Pre-Clinical Development and Stuart Ince, Ph.D. as Vice President of Program Leadership.
LEXINGTON, Mass., April 6, 2023 /PRNewswire/ -- Accent Therapeutics, a biopharmaceutical company developing breakthrough, oncology-focused small molecule therapies that target RNA-modifying proteins, today announced an upcoming presentation introducing DHX9 inhibition as a novel cancer treatment approach at the American Association for Cancer Research (AACR) Annual Meeting 2023, taking place April 14-19 in Orlando, Florida. nnAccent Therapeutics Logo nAccent Therapeutics Logo nThe oral presentation will provide rationale to support targeting inhibitors of DHX9, an RNA helicase which has been reported to play important roles in replication, transcription, translation, RNA processing and maintenance of genomic stability, as a novel therapeutic modality in microsatellite instable (MSI) colorectal cancer (CRC). The presentation will further describe the first identification of potent and selective small molecule inhibitors of DHX9 that demonstrate tumor cell killing in both in vitro and in vivo preclinical cancer models. nnThe presentation will be available on the Accent website following the meeting. nnDetails for the presentation are as follows: nnTitle: Targeting DHX9 Inhibition as a Novel Therapeutic Modality in Microsatellite Instable Colorectal Cancer nAuthors: Jennifer Castro, Matthew H. Daniels, Chuang Lu, David Brennan, Deepali Gotur, Young-Tae Lee, Kevin Knockenhauer, April Case, Jie Wu, Shane M. Buker, Julie Liu, Brian A. Sparling, E. Allen Sickmier, Stephen J. Blakemore, P. Ann Boriack-Sjodin, Kenneth W. Duncan, Scott Ribich, Robert A. Copeland nAccent Therapeutics, Lexington, MA nAbstract Number: 1136 nSession Category: Experimental and Molecular Therapeutics nSession Title: Innovative Therapeutic Approaches nSession Date and Time: Sunday, April 16, 2023 3:00 – 5:00 PM ET nSession Location: Room W331, Orange County Convention Center, Orlando, Florida nnAbout DHX9 nDHX9 is a multifunctional DEAH-box RNA helicase which has been reported to play important roles in replication, transcription, translation, RNA splicing and RNA processing which contribute to DHX9's role in maintenance of genomic stability. Overexpression of DHX9 has been observed in multiple cancer types, including colorectal cancer (CRC) and lung cancer. In addition, microsatellite instable (MSI) tumors exhibiting defective mismatch repair (dMMR) show a strong dependence on DHX9, making this helicase an attractive target for oncology drug discovery.
Tel Aviv-based Quris has built what it calls a “patient-on-a-chip” AI platform that it’s touting as a way to circumvent unreliable animal testing with a more efficient way to judge safety and efficacy. Animal testing, particularly involving mice, has proven a notoriously unreliable way to do preclinical testing — though it is well-established with regulators.
LEXINGTON, Mass.--(BUSINESS WIRE)--Accent Therapeutics, a biopharmaceutical company developing breakthrough treatments for cancer patients, announced today the appointment of Julie Hambleton, M.D., to its board of directors. Dr. Hambleton brings extensive clinical oncology drug development and regulatory expertise gained in leadership roles within both the biotechnology and pharmaceutical industries.
Since it launched in 2018, Accent Therapeutics has busied itself discovering new targets for cancer drugs in the space of RNA-modifying proteins. But the time for lying low is over—just weeks after the biotech raised a $63 million round, it’s striking its first Big Pharma partnership with AstraZeneca.