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    Chemistry

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    Also known as: Chlorphenamine, 132-22-9, Teldrin, Chlorophenylpyridamine, Chlor-trimeton, Clorfeniramina
    Molecular Formula
    C16H19ClN2
    Molecular Weight
    274.79  g/mol
    InChI Key
    SOYKEARSMXGVTM-UHFFFAOYSA-N
    FDA UNII
    3U6IO1965U
    Chlorpheniramine
    A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
    Chlorpheniramine is a Histamine-1 Receptor Antagonist. The mechanism of action of chlorpheniramine is as a Histamine H1 Receptor Antagonist.
    1 2D Structure

    Chlorpheniramine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
    2.1.2 InChI
    InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
    2.1.3 InChI Key
    SOYKEARSMXGVTM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
    2.2 Other Identifiers
    2.2.1 UNII
    3U6IO1965U
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aller-chlor

    2. Antihistaminico Llorens

    3. Chlo-amine

    4. Chlor-100

    5. Chlor-trimeton

    6. Chlor-tripolon

    7. Chlorphenamine

    8. Chlorpheniramine Maleate

    9. Chlorpheniramine Tannate

    10. Chlorpro

    11. Chlorprophenpyridamine

    12. Chlorspan 12

    13. Chlortab-4

    14. Cloro-trimeton

    15. Efidac 24

    16. Kloromin

    17. Maleate, Chlorpheniramine

    18. Piriton

    19. Tannate, Chlorpheniramine

    20. Teldrin

    2.3.2 Depositor-Supplied Synonyms

    1. Chlorphenamine

    2. 132-22-9

    3. Teldrin

    4. Chlorophenylpyridamine

    5. Chlor-trimeton

    6. Clorfeniramina

    7. Phenetron

    8. Haynon

    9. Clorfenamina

    10. Chloropheniramine-d4

    11. Chlorpheniraminum

    12. Polaronil

    13. Chlorphenaminum

    14. Chlorpheniramine Polistirex

    15. Clofeniramina

    16. 3-(4-chlorophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine

    17. 1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane

    18. 3-(p-chlorophenyl)-3-(2-pyridyl)-n,n-dimethylpropylamine

    19. Gamma-(4-chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine

    20. Gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamine

    21. 1-(p-chlorophenyl)-1-(2-pyridyl)-3-n,n-dimethylpropylamine

    22. Chlo-amine

    23. 3-(4-chlorophenyl)-n,n-dimethyl-3-pyridin-2-ylpropan-1-amine

    24. Chlorphenamine [inn]

    25. D-chlorpheniramine

    26. 2-pyridinepropanamine, Gamma-(4-chlorophenyl)-n,n-dimethyl-

    27. Chembl505

    28. Chloropheniramine

    29. Chlorprophenpyridamine

    30. Dexchlorpheniramine Free Base

    31. Allergican

    32. Allergisan

    33. Chloropiril

    34. Cloropiril

    35. Histadur

    36. Chebi:52010

    37. Chloroprophenpyridamine

    38. 3u6io1965u

    39. 25523-97-1 (free Base)

    40. Chlorphenamine (inn)

    41. 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine

    42. 3-(4-chlorophenyl)-n,n-dimethyl-3-(2-pyridyl)propan-1-amine

    43. Aller-chlor

    44. 4-chloropheniramine

    45. 2-[p-chloro-alpha-[2-(dimethylamino)ethyl]benzyl]pyridine

    46. Chlorphenamin

    47. Telachlor

    48. Clorfeniramina [italian]

    49. Clorfenamina [inn-spanish]

    50. Chlorphenaminum [inn-latin]

    51. Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-

    52. Hsdb 3032

    53. 113-92-8

    54. Einecs 205-054-0

    55. Chlorphenamine [inn:ban]

    56. Piriiton

    57. Unii-3u6io1965u

    58. Chlor-pro

    59. [3h]chlorphenamine

    60. Clofeniramina (tn)

    61. [3h]chlorpheniramine

    62. Chlorpheniramine-[d6]

    63. S-(+)-chlorpheniramine

    64. Prestwick0_000117

    65. Prestwick1_000117

    66. Prestwick2_000117

    67. Prestwick3_000117

    68. Ncgc00015227-04

    69. 5-ht,n-acetyl

    70. Schembl4219

    71. Lopac0_000261

    72. Oprea1_779072

    73. Bspbio_000134

    74. Chlorpheniramine [mi]

    75. Divk1c_000596

    76. Chlorpheniramine Maleate B.p.

    77. Spbio_002073

    78. Chlorpheniramine [hsdb]

    79. Bpbio1_000148

    80. Gtpl6976

    81. Chlorphenamine [who-dd]

    82. Chlorpheniramine [vandf]

    83. Dtxsid0022804

    84. Bdbm35938

    85. Kbio1_000596

    86. Chlorpheniramine-d6see C424303

    87. Ninds_000596

    88. 783ahi015x

    89. Hms2090m21

    90. Hms3428j07

    91. Chlorpheniramine Polistirex [usan]

    92. 2-pyridinepropanamine, .gamma.-(4-chlorophenyl)-n,n-dimethyl-

    93. Hy-b0286

    94. Bbl012285

    95. Stk736174

    96. Akos001650136

    97. Ccg-108982

    98. Db01114

    99. Sb19135

    100. Sdccgsbi-0050249.p002

    101. Idi1_000596

    102. Ncgc00015227-03

    103. Ncgc00015227-05

    104. Ncgc00015227-06

    105. Ncgc00015227-09

    106. Ncgc00015227-19

    107. Ncgc00162108-01

    108. Ncgc00162108-02

    109. Chlorpheniramine Component Of Tuzistra

    110. Cs-0009285

    111. Ft-0665002

    112. Ft-0772034

    113. Tuzistra Componenet Of Chlorpheniramine

    114. C06905

    115. D07398

    116. L000003

    117. Q420133

    118. W-108317

    119. Brd-a04553218-050-03-0

    120. Brd-a04553218-050-08-9

    121. .gamma.-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamine

    122. 2-(p-chloro-.alpha.-(2-(dimethylamino)ethyl)benzyl)pyridine

    123. N-[3-(4-chlorophenyl)-3-(2-pyridinyl)propyl]-n,n-dimethylamine #

    124. N.-propanamine, 3-(4-chlorophenyl)-3-(2-pyridyl)-n,n-dimethyl-

    125. (?)-3-(4-chlorophenyl)-n,n-dimethyl-3-(2-pyridinyl)propan-1-amine

    126. 2-pyridinepropanamine, .gamma.-(4-chlorophenyl)-n,n-dimethyl-, (s)-

    127. Pyridine, 2-[p-chloro-.alpha.-[2-(dimethylamino)ethyl]benzyl]-, (s)-(+)-

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 274.79 g/mol
    Molecular Formula C16H19ClN2
    XLogP33.4
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count5
    Exact Mass274.1236763 g/mol
    Monoisotopic Mass274.1236763 g/mol
    Topological Polar Surface Area16.1 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity249
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameChlorpheniramine maleate
    Drug LabelEd Chlortan Tablets are yellow, round, plain bottom, debossed "PH above 012" on top....
    Active IngredientChlorpheniramine maleate
    Dosage FormTablet, extended release
    RouteOral
    Strength12mg
    Market StatusOver the Counter
    CompanyAvanthi

    2 of 4  
    Drug NameChlor-trimeton
    Active IngredientChlorpheniramine maleate; pseudoephedrine sulfate
    Dosage FormTablet, extended release
    RouteOral
    Strength12mg; 8mg; 120mg
    Market StatusOver the Counter
    CompanySchering Plough

    3 of 4  
    Drug NameChlorpheniramine maleate
    Drug LabelEd Chlortan Tablets are yellow, round, plain bottom, debossed "PH above 012" on top....
    Active IngredientChlorpheniramine maleate
    Dosage FormTablet, extended release
    RouteOral
    Strength12mg
    Market StatusOver the Counter
    CompanyAvanthi

    4 of 4  
    Drug NameChlor-trimeton
    Active IngredientChlorpheniramine maleate; pseudoephedrine sulfate
    Dosage FormTablet, extended release
    RouteOral
    Strength12mg; 8mg; 120mg
    Market StatusOver the Counter
    CompanySchering Plough

    4.2 Therapeutic Uses

    Anti-Allergic Agents; Antipruritics; Histamine H1 Antagonists

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    Antihistamines are indicated in the prophylactic and symptomatic treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, and allergic conjunctivitis due to inhalant allergens and foods. /Antihistamines; Included in US product labeling/

    USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 303

    Antihistamines are indicated for the symptomatic treatment of pruritus associated with allergic reactions and of mild, uncomplicated allergic skin manifestations of urticaria and angioedema, in dermatographism, and in urticaria associated with transfusions. /Antihistamines; Included in US product labeling/

    USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 303

    Antihistamines are also used in the treatment of pruritus associated with pityriasis rosea. /Antihistamines; NOT included in US product labeling/

    USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 303

    For more Therapeutic Uses (Complete) data for CHLORPHENIRAMINE (10 total), please visit the HSDB record page.

    4.3 Drug Warning

    Use is not recommended in newborn or premature infants because this age group has an increased susceptibility to anticholinergic side effects, such as central nervous system excitation, and an increased tendency toward convulsions. A paradoxical reaction characterized by hyperexcitability may occur in children taking antihistamines. /Antihistamines/

    USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 306

    Dizziness, sedation, confusion, and hypotension may be more likely to occur in geriatric patients taking antihistamines. Geriatric patients are especially susceptible to the anticholinergic side effects, such as dryness of mouth and urinary retention (especially in males), of the antihistamines. If these side effects occur and continue or are severe, medication should probably be discontinued. /Antihistamines/

    USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 306

    Prolonged use of antihistamines ... may decrease or inhibit salivary flow, thus contributing to the development of caries, periodontal disease, oral candidiasis, and discomfort. /Antihistamines/

    USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 306

    ANTIHISTAMINE DRUGS MAY BE OF SOME USE IN MINIMIZING SERUM REACTIONS BUT ARE OF NO THERAPEUTIC VALUE...& MAY EVEN POTENTIATE TOXIC ACTION OF VENOM... /ANTIHISTAMINES/

    Garner's Veterinary Toxicology. 3rd ed., rev. by E.G.C. Clarke and M.L. Clarke. Baltimore: Williams and Wilkins, 1967., p. 445

    For more Drug Warnings (Complete) data for CHLORPHENIRAMINE (14 total), please visit the HSDB record page.

    4.4 Minimum/Potential Fatal Human Dose

    5. 5= EXTREMELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 5-50 MG/KG, BETWEEN 7 DROPS & 1 TEASPOONFUL FOR 70 KG PERSON (150 LB). /ANTIHISTAMINICS/

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-15

    4.5 Drug Indication

    For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

    5.2 MeSH Pharmacological Classification

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

    Antipruritics

    Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    CHLORPHENIRAMINE
    5.3.2 FDA UNII
    3U6IO1965U
    5.3.3 Pharmacological Classes
    Established Pharmacologic Class [EPC] - Histamine-1 Receptor Antagonist
    5.4 ATC Code

    R06AB54

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    R - Respiratory system

    R06 - Antihistamines for systemic use

    R06A - Antihistamines for systemic use

    R06AB - Substituted alkylamines

    R06AB04 - Chlorphenamine

    5.5 Absorption, Distribution and Excretion

    Absorption

    Well absorbed in the gastrointestinal tract.

    STUDIES IN MAN & EXPTL ANIMALS INDICATE THAT (3)H-CHLORPHENIRAMINE MALEATE IS RAPIDLY & QUANT ABSORBED FROM GUT. ALTHOUGH PLASMA LEVELS OF TOTAL RADIOACTIVITY ARE PROLONGED, PLASMA T/2 OF CHLORPHENIRAMINE IS ONLY 12-15 HR IN MAN & 3 HR IN DOG. T/2 IN MAN IS ABOUT 3 TIMES LONGER THAN THERAPEUTIC EFFECT...

    The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 194

    The H1 antagonists are well absorbed from the GI tract. Following oral administration, peak plasma concn are achieved in 2 to 3 hr and effects usually last 4 to 6 hr; however, some of the drugs are much longer acting ... . /Histamine Antagonists: H1 Antagonists/

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 584

    H1 blockers are among the many drugs that induce hepatic microsomal enzymes, and they may facilitate their own metabolism. /Histamine Antagonists: H1 Antagonists/

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 584

    5.6 Metabolism/Metabolites

    Primarily hepatic via Cytochrome P450 (CYP450) enzymes.

    MAIN SITE OF METABOLIC TRANSFORMATION IS LIVER. /ANTIHISTAMINES/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 607

    5.7 Biological Half-Life

    21-27 hours

    IN MAN...PLASMA T/2 OF CHLORPHENIRAMINE IS...12-15 HR...ALTHOUGH PLASMA LEVELS OF TOTAL RADIOACTIVITY ARE PROLONGED...

    The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 194

    Elimination: 14 to 25 hours

    USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 305

    5.8 Mechanism of Action

    Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

    Antihistamines used in the treatment of allergy act by competing with histamine for H1-receptor sites on effector cells. They thereby prevent, but do not reverse, responses mediated by histamine alone. Antihistamines antagonize, in varying degrees, most of the pharmacological effects of histamine, including urticaria and pruritus. Also, the anticholinergic actions of most antihistamines provide a drying effect on the nasal mucosa. /Antihistamines/

    USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 304

    H1 antagonists inhibit most responses of smooth muscle to histamine. Antagonism of the constrictor action of histamine on respiratory smooth muscle is easily shown in vivo and in vitro. /Histamine Antagonists: H1 Antagonists/

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 582

    H1 antagonists strongly block the action of histamine that results in increased permeability and formation of edema and wheal. /Histamine Antagonists: H1 Antagonists/

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 583

    Within the vascular tree, the H1 antagonists inhibit both the vasoconstrictor effects of histamine and, to a degree, the more rapid vasodilator effects that are mediated by H1 receptors on endothelial cells. Residual vasodilatation reflects the involvement of H2 receptors on smooth muscle and can be suppressed only by the concurrent administration of an H2 antagonist. Effects of the histamine antagonists on histamine induced changes in systemic blood pressure parallel these vascular effects. /Histamine Antagonists: H1 Antagonists/

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 583

    Many of the H1 antagonists tend to inhibit responses to acetylcholine that are mediated by muscarinic receptors. These atropine like actions are sufficiently prominent in some of the drugs to be manifest during clinical usage ... . /Histamine Antagonists: H1 Antagonists/

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 584

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    68

    PharmaCompass offers a list of Chlorpheniramine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Chlorpheniramine manufacturer or Chlorpheniramine supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Chlorpheniramine manufacturer or Chlorpheniramine supplier.

    API | Excipient name

    Chlorpheniramine

    Synonyms

    Chlorphenamine, 132-22-9, Teldrin, Chlorophenylpyridamine, Chlor-trimeton, Clorfeniramina

    Cas Number

    113-92-8

    Unique Ingredient Identifier (UNII)

    3U6IO1965U

    About Chlorpheniramine

    A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.

    Chlorpheniramine Manufacturers

    A Chlorpheniramine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chlorpheniramine, including repackagers and relabelers. The FDA regulates Chlorpheniramine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chlorpheniramine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Chlorpheniramine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PhamaCompass.

    Chlorpheniramine Suppliers

    A Chlorpheniramine supplier is an individual or a company that provides Chlorpheniramine active pharmaceutical ingredient (API) or Chlorpheniramine finished formulations upon request. The Chlorpheniramine suppliers may include Chlorpheniramine API manufacturers, exporters, distributors and traders.

    click here to find a list of Chlorpheniramine suppliers with USDMF, JDMF, KDMF, CEP, GMP, and COA related information on PharmaCompass.

    Chlorpheniramine USDMF

    A Chlorpheniramine DMF (Drug Master File) is a document detailing the whole manufacturing process of Chlorpheniramine active pharmaceutical ingredient (API) in detail. Different forms of Chlorpheniramine DMFs exist exist since differing nations have different regulations, such as Chlorpheniramine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Chlorpheniramine DMF submitted to regulatory agencies in the US is known as a USDMF. Chlorpheniramine USDMF includes data on Chlorpheniramine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Chlorpheniramine USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Chlorpheniramine suppliers with USDMF on PharmaCompass.

    Chlorpheniramine CEP

    A Chlorpheniramine CEP of the European Pharmacopoeia monograph is often referred to as a Chlorpheniramine Certificate of Suitability (COS). The purpose of a Chlorpheniramine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Chlorpheniramine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Chlorpheniramine to their clients by showing that a Chlorpheniramine CEP has been issued for it. The manufacturer submits a Chlorpheniramine CEP (COS) as part of the market authorization procedure, and it takes on the role of a Chlorpheniramine CEP holder for the record. Additionally, the data presented in the Chlorpheniramine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Chlorpheniramine DMF.

    A Chlorpheniramine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Chlorpheniramine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Chlorpheniramine suppliers with CEP (COS) on PharmaCompass.

    Chlorpheniramine NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Chlorpheniramine as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Chlorpheniramine API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Chlorpheniramine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Chlorpheniramine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Chlorpheniramine NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Chlorpheniramine suppliers with NDC on PharmaCompass.

    Chlorpheniramine GMP

    Chlorpheniramine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Chlorpheniramine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, and more, enabling you to easily find the right Chlorpheniramine GMP manufacturer or Chlorpheniramine GMP API supplier for your needs.

    Chlorpheniramine CoA

    A Chlorpheniramine CoA (Certificate of Analysis) is a formal document that attests to Chlorpheniramine's compliance with Chlorpheniramine specifications and serves as a tool for batch-level quality control.

    Chlorpheniramine CoA mostly includes findings from lab analyses of a specific batch. For each Chlorpheniramine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Chlorpheniramine may be tested according to a variety of international standards, such as European Pharmacopoeia (Chlorpheniramine EP), Chlorpheniramine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chlorpheniramine USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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