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Chemistry

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Also known as: Chlorphenamine, 132-22-9, Teldrin, Chlorophenylpyridamine, Chlor-trimeton, Clorfeniramina
Molecular Formula
C16H19ClN2
Molecular Weight
274.79  g/mol
InChI Key
SOYKEARSMXGVTM-UHFFFAOYSA-N
FDA UNII
3U6IO1965U

Chlorpheniramine
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
Chlorpheniramine is a Histamine-1 Receptor Antagonist. The mechanism of action of chlorpheniramine is as a Histamine H1 Receptor Antagonist.
1 2D Structure

Chlorpheniramine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
2.1.2 InChI
InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
2.1.3 InChI Key
SOYKEARSMXGVTM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2
2.2 Other Identifiers
2.2.1 UNII
3U6IO1965U
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Aller-chlor

2. Antihistaminico Llorens

3. Chlo-amine

4. Chlor-100

5. Chlor-trimeton

6. Chlor-tripolon

7. Chlorphenamine

8. Chlorpheniramine Maleate

9. Chlorpheniramine Tannate

10. Chlorpro

11. Chlorprophenpyridamine

12. Chlorspan 12

13. Chlortab-4

14. Cloro-trimeton

15. Efidac 24

16. Kloromin

17. Maleate, Chlorpheniramine

18. Piriton

19. Tannate, Chlorpheniramine

20. Teldrin

2.3.2 Depositor-Supplied Synonyms

1. Chlorphenamine

2. 132-22-9

3. Teldrin

4. Chlorophenylpyridamine

5. Chlor-trimeton

6. Clorfeniramina

7. Phenetron

8. Haynon

9. Clorfenamina

10. Chloropheniramine-d4

11. Chlorpheniraminum

12. Polaronil

13. Chlorphenaminum

14. Chlorpheniramine Polistirex

15. Clofeniramina

16. 3-(4-chlorophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine

17. 1-(p-chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane

18. 3-(p-chlorophenyl)-3-(2-pyridyl)-n,n-dimethylpropylamine

19. Gamma-(4-chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine

20. Gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamine

21. 1-(p-chlorophenyl)-1-(2-pyridyl)-3-n,n-dimethylpropylamine

22. Chlo-amine

23. 3-(4-chlorophenyl)-n,n-dimethyl-3-pyridin-2-ylpropan-1-amine

24. Chlorphenamine [inn]

25. D-chlorpheniramine

26. 2-pyridinepropanamine, Gamma-(4-chlorophenyl)-n,n-dimethyl-

27. Chembl505

28. Chloropheniramine

29. Chlorprophenpyridamine

30. Dexchlorpheniramine Free Base

31. Allergican

32. Allergisan

33. Chloropiril

34. Cloropiril

35. Histadur

36. Chebi:52010

37. Chloroprophenpyridamine

38. 3u6io1965u

39. 25523-97-1 (free Base)

40. Chlorphenamine (inn)

41. 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine

42. 3-(4-chlorophenyl)-n,n-dimethyl-3-(2-pyridyl)propan-1-amine

43. Aller-chlor

44. 4-chloropheniramine

45. 2-[p-chloro-alpha-[2-(dimethylamino)ethyl]benzyl]pyridine

46. Chlorphenamin

47. Telachlor

48. Clorfeniramina [italian]

49. Clorfenamina [inn-spanish]

50. Chlorphenaminum [inn-latin]

51. Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-

52. Hsdb 3032

53. 113-92-8

54. Einecs 205-054-0

55. Chlorphenamine [inn:ban]

56. Piriiton

57. Unii-3u6io1965u

58. Chlor-pro

59. [3h]chlorphenamine

60. Clofeniramina (tn)

61. [3h]chlorpheniramine

62. Chlorpheniramine-[d6]

63. S-(+)-chlorpheniramine

64. Prestwick0_000117

65. Prestwick1_000117

66. Prestwick2_000117

67. Prestwick3_000117

68. Ncgc00015227-04

69. 5-ht,n-acetyl

70. Schembl4219

71. Lopac0_000261

72. Oprea1_779072

73. Bspbio_000134

74. Chlorpheniramine [mi]

75. Divk1c_000596

76. Chlorpheniramine Maleate B.p.

77. Spbio_002073

78. Chlorpheniramine [hsdb]

79. Bpbio1_000148

80. Gtpl6976

81. Chlorphenamine [who-dd]

82. Chlorpheniramine [vandf]

83. Dtxsid0022804

84. Bdbm35938

85. Kbio1_000596

86. Chlorpheniramine-d6see C424303

87. Ninds_000596

88. 783ahi015x

89. Hms2090m21

90. Hms3428j07

91. Chlorpheniramine Polistirex [usan]

92. 2-pyridinepropanamine, .gamma.-(4-chlorophenyl)-n,n-dimethyl-

93. Hy-b0286

94. Bbl012285

95. Stk736174

96. Akos001650136

97. Ccg-108982

98. Db01114

99. Sb19135

100. Sdccgsbi-0050249.p002

101. Idi1_000596

102. Ncgc00015227-03

103. Ncgc00015227-05

104. Ncgc00015227-06

105. Ncgc00015227-09

106. Ncgc00015227-19

107. Ncgc00162108-01

108. Ncgc00162108-02

109. Chlorpheniramine Component Of Tuzistra

110. Cs-0009285

111. Ft-0665002

112. Ft-0772034

113. Tuzistra Componenet Of Chlorpheniramine

114. C06905

115. D07398

116. L000003

117. Q420133

118. W-108317

119. Brd-a04553218-050-03-0

120. Brd-a04553218-050-08-9

121. .gamma.-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamine

122. 2-(p-chloro-.alpha.-(2-(dimethylamino)ethyl)benzyl)pyridine

123. N-[3-(4-chlorophenyl)-3-(2-pyridinyl)propyl]-n,n-dimethylamine #

124. N.-propanamine, 3-(4-chlorophenyl)-3-(2-pyridyl)-n,n-dimethyl-

125. (?)-3-(4-chlorophenyl)-n,n-dimethyl-3-(2-pyridinyl)propan-1-amine

126. 2-pyridinepropanamine, .gamma.-(4-chlorophenyl)-n,n-dimethyl-, (s)-

127. Pyridine, 2-[p-chloro-.alpha.-[2-(dimethylamino)ethyl]benzyl]-, (s)-(+)-

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 274.79 g/mol
Molecular Formula C16H19ClN2
XLogP33.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass274.1236763 g/mol
Monoisotopic Mass274.1236763 g/mol
Topological Polar Surface Area16.1 Ų
Heavy Atom Count19
Formal Charge0
Complexity249
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameChlorpheniramine maleate
Drug LabelEd Chlortan Tablets are yellow, round, plain bottom, debossed "PH above 012" on top....
Active IngredientChlorpheniramine maleate
Dosage FormTablet, extended release
RouteOral
Strength12mg
Market StatusOver the Counter
CompanyAvanthi

2 of 4  
Drug NameChlor-trimeton
Active IngredientChlorpheniramine maleate; pseudoephedrine sulfate
Dosage FormTablet, extended release
RouteOral
Strength12mg; 8mg; 120mg
Market StatusOver the Counter
CompanySchering Plough

3 of 4  
Drug NameChlorpheniramine maleate
Drug LabelEd Chlortan Tablets are yellow, round, plain bottom, debossed "PH above 012" on top....
Active IngredientChlorpheniramine maleate
Dosage FormTablet, extended release
RouteOral
Strength12mg
Market StatusOver the Counter
CompanyAvanthi

4 of 4  
Drug NameChlor-trimeton
Active IngredientChlorpheniramine maleate; pseudoephedrine sulfate
Dosage FormTablet, extended release
RouteOral
Strength12mg; 8mg; 120mg
Market StatusOver the Counter
CompanySchering Plough

4.2 Therapeutic Uses

Anti-Allergic Agents; Antipruritics; Histamine H1 Antagonists

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


Antihistamines are indicated in the prophylactic and symptomatic treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, and allergic conjunctivitis due to inhalant allergens and foods. /Antihistamines; Included in US product labeling/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 303


Antihistamines are indicated for the symptomatic treatment of pruritus associated with allergic reactions and of mild, uncomplicated allergic skin manifestations of urticaria and angioedema, in dermatographism, and in urticaria associated with transfusions. /Antihistamines; Included in US product labeling/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 303


Antihistamines are also used in the treatment of pruritus associated with pityriasis rosea. /Antihistamines; NOT included in US product labeling/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 303


For more Therapeutic Uses (Complete) data for CHLORPHENIRAMINE (10 total), please visit the HSDB record page.


4.3 Drug Warning

Use is not recommended in newborn or premature infants because this age group has an increased susceptibility to anticholinergic side effects, such as central nervous system excitation, and an increased tendency toward convulsions. A paradoxical reaction characterized by hyperexcitability may occur in children taking antihistamines. /Antihistamines/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 306


Dizziness, sedation, confusion, and hypotension may be more likely to occur in geriatric patients taking antihistamines. Geriatric patients are especially susceptible to the anticholinergic side effects, such as dryness of mouth and urinary retention (especially in males), of the antihistamines. If these side effects occur and continue or are severe, medication should probably be discontinued. /Antihistamines/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 306


Prolonged use of antihistamines ... may decrease or inhibit salivary flow, thus contributing to the development of caries, periodontal disease, oral candidiasis, and discomfort. /Antihistamines/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 306


ANTIHISTAMINE DRUGS MAY BE OF SOME USE IN MINIMIZING SERUM REACTIONS BUT ARE OF NO THERAPEUTIC VALUE...& MAY EVEN POTENTIATE TOXIC ACTION OF VENOM... /ANTIHISTAMINES/

Garner's Veterinary Toxicology. 3rd ed., rev. by E.G.C. Clarke and M.L. Clarke. Baltimore: Williams and Wilkins, 1967., p. 445


For more Drug Warnings (Complete) data for CHLORPHENIRAMINE (14 total), please visit the HSDB record page.


4.4 Minimum/Potential Fatal Human Dose

5. 5= EXTREMELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 5-50 MG/KG, BETWEEN 7 DROPS & 1 TEASPOONFUL FOR 70 KG PERSON (150 LB). /ANTIHISTAMINICS/

Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-15


4.5 Drug Indication

For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.


5 Pharmacology and Biochemistry
5.1 Pharmacology

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Chlorpheniramine, is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.


5.2 MeSH Pharmacological Classification

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)


Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)


Antipruritics

Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
CHLORPHENIRAMINE
5.3.2 FDA UNII
3U6IO1965U
5.3.3 Pharmacological Classes
Established Pharmacologic Class [EPC] - Histamine-1 Receptor Antagonist
5.4 ATC Code

R06AB54

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


R - Respiratory system

R06 - Antihistamines for systemic use

R06A - Antihistamines for systemic use

R06AB - Substituted alkylamines

R06AB04 - Chlorphenamine


5.5 Absorption, Distribution and Excretion

Absorption

Well absorbed in the gastrointestinal tract.


STUDIES IN MAN & EXPTL ANIMALS INDICATE THAT (3)H-CHLORPHENIRAMINE MALEATE IS RAPIDLY & QUANT ABSORBED FROM GUT. ALTHOUGH PLASMA LEVELS OF TOTAL RADIOACTIVITY ARE PROLONGED, PLASMA T/2 OF CHLORPHENIRAMINE IS ONLY 12-15 HR IN MAN & 3 HR IN DOG. T/2 IN MAN IS ABOUT 3 TIMES LONGER THAN THERAPEUTIC EFFECT...

The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 194


The H1 antagonists are well absorbed from the GI tract. Following oral administration, peak plasma concn are achieved in 2 to 3 hr and effects usually last 4 to 6 hr; however, some of the drugs are much longer acting ... . /Histamine Antagonists: H1 Antagonists/

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 584


H1 blockers are among the many drugs that induce hepatic microsomal enzymes, and they may facilitate their own metabolism. /Histamine Antagonists: H1 Antagonists/

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 584


5.6 Metabolism/Metabolites

Primarily hepatic via Cytochrome P450 (CYP450) enzymes.


MAIN SITE OF METABOLIC TRANSFORMATION IS LIVER. /ANTIHISTAMINES/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 607


5.7 Biological Half-Life

21-27 hours


IN MAN...PLASMA T/2 OF CHLORPHENIRAMINE IS...12-15 HR...ALTHOUGH PLASMA LEVELS OF TOTAL RADIOACTIVITY ARE PROLONGED...

The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 194


Elimination: 14 to 25 hours

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 305


5.8 Mechanism of Action

Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.


Antihistamines used in the treatment of allergy act by competing with histamine for H1-receptor sites on effector cells. They thereby prevent, but do not reverse, responses mediated by histamine alone. Antihistamines antagonize, in varying degrees, most of the pharmacological effects of histamine, including urticaria and pruritus. Also, the anticholinergic actions of most antihistamines provide a drying effect on the nasal mucosa. /Antihistamines/

USP Convention. USPDI - Drug Information for the Health Care Professional. 15 th ed. Volume 1. Rockville, MD: United States Pharmacopeial Convention, Inc., 1995. (Plus updates.), p. 304


H1 antagonists inhibit most responses of smooth muscle to histamine. Antagonism of the constrictor action of histamine on respiratory smooth muscle is easily shown in vivo and in vitro. /Histamine Antagonists: H1 Antagonists/

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 582


H1 antagonists strongly block the action of histamine that results in increased permeability and formation of edema and wheal. /Histamine Antagonists: H1 Antagonists/

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 583


Within the vascular tree, the H1 antagonists inhibit both the vasoconstrictor effects of histamine and, to a degree, the more rapid vasodilator effects that are mediated by H1 receptors on endothelial cells. Residual vasodilatation reflects the involvement of H2 receptors on smooth muscle and can be suppressed only by the concurrent administration of an H2 antagonist. Effects of the histamine antagonists on histamine induced changes in systemic blood pressure parallel these vascular effects. /Histamine Antagonists: H1 Antagonists/

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 583


Many of the H1 antagonists tend to inhibit responses to acetylcholine that are mediated by muscarinic receptors. These atropine like actions are sufficiently prominent in some of the drugs to be manifest during clinical usage ... . /Histamine Antagonists: H1 Antagonists/

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 584


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30-Apr-2025
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ABOUT THIS PAGE

Looking for 113-92-8 / Chlorpheniramine API manufacturers, exporters & distributors?

Chlorpheniramine manufacturers, exporters & distributors 1

46

PharmaCompass offers a list of Chlorpheniramine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Chlorpheniramine manufacturer or Chlorpheniramine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Chlorpheniramine manufacturer or Chlorpheniramine supplier.

PharmaCompass also assists you with knowing the Chlorpheniramine API Price utilized in the formulation of products. Chlorpheniramine API Price is not always fixed or binding as the Chlorpheniramine Price is obtained through a variety of data sources. The Chlorpheniramine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Chlorpheniramine

Synonyms

Chlorphenamine, 132-22-9, Teldrin, Chlorophenylpyridamine, Chlor-trimeton, Clorfeniramina

Cas Number

113-92-8

Unique Ingredient Identifier (UNII)

3U6IO1965U

About Chlorpheniramine

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.

Chlorpheniramine Manufacturers

A Chlorpheniramine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Chlorpheniramine, including repackagers and relabelers. The FDA regulates Chlorpheniramine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Chlorpheniramine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Chlorpheniramine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Chlorpheniramine Suppliers

A Chlorpheniramine supplier is an individual or a company that provides Chlorpheniramine active pharmaceutical ingredient (API) or Chlorpheniramine finished formulations upon request. The Chlorpheniramine suppliers may include Chlorpheniramine API manufacturers, exporters, distributors and traders.

click here to find a list of Chlorpheniramine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Chlorpheniramine USDMF

A Chlorpheniramine DMF (Drug Master File) is a document detailing the whole manufacturing process of Chlorpheniramine active pharmaceutical ingredient (API) in detail. Different forms of Chlorpheniramine DMFs exist exist since differing nations have different regulations, such as Chlorpheniramine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Chlorpheniramine DMF submitted to regulatory agencies in the US is known as a USDMF. Chlorpheniramine USDMF includes data on Chlorpheniramine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Chlorpheniramine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Chlorpheniramine suppliers with USDMF on PharmaCompass.

Chlorpheniramine CEP

A Chlorpheniramine CEP of the European Pharmacopoeia monograph is often referred to as a Chlorpheniramine Certificate of Suitability (COS). The purpose of a Chlorpheniramine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Chlorpheniramine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Chlorpheniramine to their clients by showing that a Chlorpheniramine CEP has been issued for it. The manufacturer submits a Chlorpheniramine CEP (COS) as part of the market authorization procedure, and it takes on the role of a Chlorpheniramine CEP holder for the record. Additionally, the data presented in the Chlorpheniramine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Chlorpheniramine DMF.

A Chlorpheniramine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Chlorpheniramine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Chlorpheniramine suppliers with CEP (COS) on PharmaCompass.

Chlorpheniramine NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Chlorpheniramine as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Chlorpheniramine API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Chlorpheniramine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Chlorpheniramine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Chlorpheniramine NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Chlorpheniramine suppliers with NDC on PharmaCompass.

Chlorpheniramine GMP

Chlorpheniramine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Chlorpheniramine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Chlorpheniramine GMP manufacturer or Chlorpheniramine GMP API supplier for your needs.

Chlorpheniramine CoA

A Chlorpheniramine CoA (Certificate of Analysis) is a formal document that attests to Chlorpheniramine's compliance with Chlorpheniramine specifications and serves as a tool for batch-level quality control.

Chlorpheniramine CoA mostly includes findings from lab analyses of a specific batch. For each Chlorpheniramine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Chlorpheniramine may be tested according to a variety of international standards, such as European Pharmacopoeia (Chlorpheniramine EP), Chlorpheniramine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Chlorpheniramine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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