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Chemistry

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Also known as: 481-49-2, Cepharanthin, (+)-cepharanthine, O-methylcepharanoline, Cepharantin, Cepharanthine [jan]
Molecular Formula
C37H38N2O6
Molecular Weight
606.7  g/mol
InChI Key
YVPXVXANRNDGTA-WDYNHAJCSA-N
FDA UNII
7592YJ0J6T

Cepharanthine
(14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2,.1,.1,.0,.0,.0,]nonatriaconta-1(34),3,8,10(39),16,18,21(36),22,24,31(35),32,37-dodecaene is a natural product found in Stephania sinica, Stephania cephalantha, and other organisms with data available.
1 2D Structure

Cepharanthine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene
2.1.2 InChI
InChI=1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1
2.1.3 InChI Key
YVPXVXANRNDGTA-WDYNHAJCSA-N
2.1.4 Canonical SMILES
CN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
2.1.5 Isomeric SMILES
CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
2.2 Other Identifiers
2.2.1 UNII
7592YJ0J6T
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6',12'-dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan

2. Cepharanthin

2.3.2 Depositor-Supplied Synonyms

1. 481-49-2

2. Cepharanthin

3. (+)-cepharanthine

4. O-methylcepharanoline

5. Cepharantin

6. Cepharanthine [jan]

7. 6',12'-dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan

8. Nsc-623442

9. Chebi:3546

10. 7592yj0j6t

11. Nsc623442

12. Cepharanthine (jan)

13. (14s,27r)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene

14. Oxyacanthan, 6',12'-dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))-

15. Ecaene (non-preferred Name)

16. Dsstox_cid_25957

17. Dsstox_rid_81253

18. Dsstox_gsid_45957

19. 22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene

20. Cas-481-49-2

21. Ccris 6539

22. Sr-01000779734

23. Nsc 623442

24. Brn 0075231

25. Unii-7592yj0j6t

26. Cepharanthin,(s)

27. Ncgc00095194-01

28. (14s,27r)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dod

29. Cepharanthine (tn)

30. Spectrum2_000832

31. Spectrum3_001963

32. 12-o-methylcepharanoline

33. Cepharanthine [mi]

34. Upcmld-dp054

35. Bspbio_003563

36. 4-27-00-09061 (beilstein Handbook Reference)

37. Mls000728518

38. Schembl154545

39. Spectrum1505322

40. Spbio_000783

41. Cepharanthine [who-dd]

42. Chembl449782

43. Dtxsid6045957

44. Upcmld-dp054:001

45. Kbio3_002909

46. Cepharanthine, >=95% (hplc)

47. Cepharanthine, >=98% (hplc)

48. Hms1922j12

49. Hms2232f21

50. Pharmakon1600-01505322

51. Hy-n6972

52. Tox21_111483

53. Bbl030154

54. Bdbm50423643

55. Ccg-40294

56. Mfcd00210482

57. Nsc758965

58. S4238

59. Stk801907

60. Zinc30726863

61. Akos004119865

62. Tox21_111483_1

63. Nsc-758965

64. Sdccgmls-0066893.p001

65. Ncgc00161621-01

66. Ncgc00161621-02

67. Ncgc00161621-03

68. Ncgc00161621-05

69. Ncgc00161621-13

70. Ac-15206

71. As-17451

72. Smr000445632

73. Sbi-0207049.p001

74. Cs-0007138

75. M2968

76. C09391

77. D01035

78. Ab00643356_08

79. Ab00643356_09

80. 481c492

81. A871948

82. Q-100524

83. Sr-01000779734-3

84. Sr-01000779734-4

85. Brd-k96194081-001-06-0

86. Q15410888

87. (14s,27r)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2(16,19).1(3,10).1(21,25).0(4,8).0(14,39).0(31,35)]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene

88. (14s,27r)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2??,??.1?,??.1??,??.0?,?.0??,??.0??,??]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 606.7 g/mol
Molecular Formula C37H38N2O6
XLogP36.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count2
Exact Mass606.27298694 g/mol
Monoisotopic Mass606.27298694 g/mol
Topological Polar Surface Area61.9 Ų
Heavy Atom Count45
Formal Charge0
Complexity994
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


Radiation-Protective Agents

Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other purposes, e.g. military. (See all compounds classified as Radiation-Protective Agents.)


Antineoplastic Agents, Phytogenic

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)


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ABOUT THIS PAGE

Looking for 481-49-2 / Cepharanthine API manufacturers, exporters & distributors?

Cepharanthine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Cepharanthine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Cepharanthine manufacturer or Cepharanthine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Cepharanthine manufacturer or Cepharanthine supplier.

PharmaCompass also assists you with knowing the Cepharanthine API Price utilized in the formulation of products. Cepharanthine API Price is not always fixed or binding as the Cepharanthine Price is obtained through a variety of data sources. The Cepharanthine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Cepharanthine

Synonyms

481-49-2, Cepharanthin, (+)-cepharanthine, O-methylcepharanoline, Cepharantin, Cepharanthine [jan]

Cas Number

481-49-2

Unique Ingredient Identifier (UNII)

7592YJ0J6T

About Cepharanthine

(14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2,.1,.1,.0,.0,.0,]nonatriaconta-1(34),3,8,10(39),16,18,21(36),22,24,31(35),32,37-dodecaene is a natural product found in Stephania sinica, Stephania cephalantha, and other organisms with data available.

Cepharanthine Manufacturers

A Cepharanthine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Cepharanthine, including repackagers and relabelers. The FDA regulates Cepharanthine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Cepharanthine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Cepharanthine Suppliers

A Cepharanthine supplier is an individual or a company that provides Cepharanthine active pharmaceutical ingredient (API) or Cepharanthine finished formulations upon request. The Cepharanthine suppliers may include Cepharanthine API manufacturers, exporters, distributors and traders.

Cepharanthine GMP

Cepharanthine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Cepharanthine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Cepharanthine GMP manufacturer or Cepharanthine GMP API supplier for your needs.

Cepharanthine CoA

A Cepharanthine CoA (Certificate of Analysis) is a formal document that attests to Cepharanthine's compliance with Cepharanthine specifications and serves as a tool for batch-level quality control.

Cepharanthine CoA mostly includes findings from lab analyses of a specific batch. For each Cepharanthine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Cepharanthine may be tested according to a variety of international standards, such as European Pharmacopoeia (Cepharanthine EP), Cepharanthine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Cepharanthine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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