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    [{"orgOrder":0,"company":"Bristol Myers Squibb","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Enasidenib","moa":"||IDH","graph1":"Oncology","graph2":"Approved FDF","graph3":"Bristol Myers Squibb","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Bristol Myers Squibb \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Bristol Myers Squibb \/ Inapplicable"},{"orgOrder":0,"company":"Theravia","sponsor":"Norgine","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"FRANCE","productType":"Cytotoxic Drug","year":"2025","type":"Acquisition","leadProduct":"Hydroxyurea","moa":"||DNA synthesis","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Theravia","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral Tablet, Film Coated","sponsorNew":"Theravia \/ Norgine","highestDevelopmentStatusID":"15","companyTruncated":"Theravia \/ Norgine"},{"orgOrder":0,"company":"Global Health Uganda","sponsor":"Columbia University | The University of Pittsburgh School of Medicine | Gabrail Cancer Center Research | Mulago Hospital, Uganda | Makerere University | Gansu Provincial Maternal and Child Health Care Hospital","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"","productType":"Cytotoxic Drug","year":"2021","type":"Inapplicable","leadProduct":"Hydroxyurea","moa":"||Ribonucleoside-diphosphate reductase RR1","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Global Health Uganda","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral","sponsorNew":"Global Health Uganda \/ Columbia University | The University of Pittsburgh School of Medicine | Gabrail Cancer Center Research | Mulago Hospital, Uganda | Makerere University | Gansu Provincial Maternal and Child Health Care Hospital","highestDevelopmentStatusID":"10","companyTruncated":"Global Health Uganda \/ Columbia University | The University of Pittsburgh School of Medicine | Gabrail Cancer Center Research | Mulago Hospital, Uganda | Makerere University | Gansu Provincial Maternal and Child Health Care Hospital"},{"orgOrder":0,"company":"Theravia","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"FRANCE","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Hydroxyurea","moa":"||Ribonucleoside-diphosphate reductase RR1","graph1":"Genetic Disease","graph2":"Phase II","graph3":"Theravia","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Theravia \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Theravia \/ Inapplicable"},{"orgOrder":0,"company":"Theravia","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"FRANCE","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Hydroxyurea","moa":"||Ribonucleoside-diphosphate reductase RR1","graph1":"Genetic Disease","graph2":"Phase II","graph3":"Theravia","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Theravia \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Theravia \/ Inapplicable"},{"orgOrder":0,"company":"Novartis Pharmaceuticals Corporation","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"SWITZERLAND","productType":"Cytotoxic Drug","year":"2023","type":"Inapplicable","leadProduct":"Hydroxyurea","moa":"||Ribonucleoside-diphosphate reductase RR1","graph1":"Oncology","graph2":"Phase IV","graph3":"Novartis Pharmaceuticals Corporation","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Novartis Pharmaceuticals Corporation \/ Inapplicable","highestDevelopmentStatusID":"11","companyTruncated":"Novartis Pharmaceuticals Corporation \/ Inapplicable"},{"orgOrder":0,"company":"Brown University","sponsor":"National Heart, Lung, and Blood Institute | Novartis Pharmaceuticals Corporation","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"","productType":"Cytotoxic Drug","year":"2022","type":"Inapplicable","leadProduct":"Hydroxyurea","moa":"||Ribonucleoside-diphosphate reductase RR1","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Brown University","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Brown University \/ National Heart, Lung, and Blood Institute | Novartis Pharmaceuticals Corporation","highestDevelopmentStatusID":"10","companyTruncated":"Brown University \/ National Heart, Lung, and Blood Institute | Novartis Pharmaceuticals Corporation"},{"orgOrder":0,"company":"Uma Borate","sponsor":"Kura Oncology","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"Bone Marrow Aspiration","moa":"||Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"Uma Borate","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Uma Borate \/ Kura Oncology","highestDevelopmentStatusID":"8","companyTruncated":"Uma Borate \/ Kura Oncology"},{"orgOrder":0,"company":"Theravia","sponsor":"Simbec-Orion | Oncodesign | PhinC Development","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"FRANCE","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Hydroxyurea","moa":"||Ribonucleoside-diphosphate reductase RR1","graph1":"Undisclosed","graph2":"Phase I","graph3":"Theravia","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Theravia \/ Simbec-Orion | Oncodesign | PhinC Development","highestDevelopmentStatusID":"6","companyTruncated":"Theravia \/ Simbec-Orion | Oncodesign | PhinC Development"}]

    Find Clinical Drug Pipeline Developments & Deals for Urea, hydroxy-

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                            01

                            Sanofi

                            France
                            ChemOutsourcing
                            Attending
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

                            Lead Product(s) : Isatuximab,Dexamethasone,Fludarabine Phosphate,Cytarabine,Daunorubicin,Idarubicin Hydrochloride,Filgrastim,Mitoxantrone,Doxorubicin Hydrochloride,Vincristine Sulfate,Peg L asparaginase,Cyclophosphamide,Etoposide,Methotrexate,L - Asparaginase,Hydroxyurea

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Isatuximab in Combination With Chemotherapy in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 04, 2019

                            Lead Product(s) : Isatuximab,Dexamethasone,Fludarabine Phosphate,Cytarabine,Daunorubicin,Idarubicin Hydrochloride,Filgrastim,Mitoxantrone,Doxorubicin Hydrochloride,Vincristine Sulfate,Peg L asparaginase,Cyclophosphamide,Etoposide,Methotrexate,L - Asparaginase,Hydroxyurea

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Uma Borate

                            Country arrow
                            EPSC
                            Not Confirmed

                            Uma Borate

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                            EPSC
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

                            Lead Product(s) : Bone Marrow Aspiration,Cytarabine,Hydroxyurea,Ziftomenib

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Kura Oncology

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Ziftomenib for the Treatment of Patients With NPM1 Mutated or KMT2A Rearranged Acute Myeloid Leukemia Not Elig...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            April 16, 2025

                            Lead Product(s) : Bone Marrow Aspiration,Cytarabine,Hydroxyurea,Ziftomenib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Kura Oncology

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Theravia

                            France arrow
                            EPSC
                            Not Confirmed

                            Theravia

                            France arrow
                            EPSC
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Norgine

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Norgine Strengthens Rare Disease Portfolio with Acquisition of Theravia

                            Details : Through the acquisition, Norgine will have six core products in its rare disease portfolio, which includes Siklos (hydroxyurea) is being indicated for the treatment of sickle cell anemia.

                            Product Name : Siklos

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Undisclosed

                            April 15, 2025

                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Norgine

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            04

                            Theravia

                            France arrow
                            EPSC
                            Not Confirmed

                            Theravia

                            France arrow
                            EPSC
                            Not Confirmed
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                            • EDQM
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                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Pharmacokinetics, Efficacy and Safety of Twice Daily Dosing Regimen of Hydroxycarbamide Dispersible Tablets in...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 29, 2024

                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Novartis Pharmaceuticals Corporation

                            Switzerland arrow
                            EPSC
                            Not Confirmed

                            Novartis Pharmaceuticals Corporation

                            Switzerland arrow
                            EPSC
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Oncology

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Evaluation of HU-resistance in Adult Patients With Polycythemia Vera Who Meet PV-AIM Predictors

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            May 10, 2023

                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Theravia

                            France arrow
                            EPSC
                            Not Confirmed

                            Theravia

                            France arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Acceptability of a New Paediatric Formulation of Hydroxycarbamide in Children With Sickle Cell Disease.

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 22, 2022

                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Brown University

                            Country arrow
                            EPSC
                            Not Confirmed

                            Brown University

                            Country arrow
                            EPSC
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : National Heart, Lung, and Blood Institute | Novartis Pharmaceuticals Corporation

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Promoting Utilization and Safety of Hydroxyurea Using Precision in Africa

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            March 18, 2022

                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : National Heart, Lung, and Blood Institute | Novartis Pharmaceuticals Corporation

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Theravia

                            France arrow
                            EPSC
                            Not Confirmed

                            Theravia

                            France arrow
                            EPSC
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Simbec-Orion | Oncodesign | PhinC Development

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Bioequivalence Study to Compare the Pharmacokinetics of Two Formulations of Siklos® in Healthy Volunteers

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 27, 2021

                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Simbec-Orion | Oncodesign | PhinC Development

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Global Health Uganda

                            Country arrow
                            EPSC
                            Not Confirmed

                            Global Health Uganda

                            Country arrow
                            EPSC
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Columbia University | The University of Pittsburgh School of Medicine | Gabrail Cancer Center Research | Mulago Hospital, Uganda | Makerere University | Gansu Provincial Maternal and Child Health Care Hospital

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Hydroxyurea Therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda ( BRAI...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            February 11, 2021

                            Lead Product(s) : Hydroxyurea,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Columbia University | The University of Pittsburgh School of Medicine | Gabrail Cancer Center Research | Mulago Hospital, Uganda | Makerere University | Gansu Provincial Maternal and Child Health Care Hospital

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Bristol Myers Squibb

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Bristol Myers Squibb

                            U.S.A arrow
                            EPSC
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
                            Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

                            Lead Product(s) : Enasidenib,Hydroxyurea

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Bristol Myers Squibb Provides Update on Phase 3 IDHENTIFY Trial in Patients with Relapsed or Refractory Acute ...

                            Details : Phase 3 IDHENTIFY study evaluating IDHIFA®(enasidenib) plus best supportive care vs conventional care regimens, which include azacitidine plus BSC, low-dose cytarabine plus BSC or intermediate-dose cytarabine plus BSC, did not meet the primary endpoint.

                            Product Name : Idhifa

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 25, 2020

                            Lead Product(s) : Enasidenib,Hydroxyurea

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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