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Find Drugs for Trauma (Emergency, Injury, Surgery) in Preclinical Development in UNITED STATES

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            Lead Product(s): ST266

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: ST266

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Walter Reed Army Institute

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration February 01, 2021

            Details:

            The TBI models will utilize targeted intranasal nose-to-brain administration of ST266. The ultimate goals are to advance ST266 into human clinical trials of targeted intranasal administration for TBI.

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            Lead Product(s): Tipelukast

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: MN-001

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: National Institute of General Medical Sciences

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 12, 2020

            Details:

            The study sought to examine the pathogenic role of phosphodiesterase 4 (PDE4) in hepatic stellate cell (HSC) activation and TGFβ1 (transforming growth factor beta 1) signaling. TGFβ1 induced HSC activation.

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            Lead Product(s): CX717

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: CX717

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 06, 2020

            Details:

            Studies describes the ability of CX717, one of the Company’s lead ampakines, to improve motor nerve function in an animal model of spinal cord injury. CX717 improved the electrical activity of the phrenic motor nerve when recorded below the site of the spinal injury.

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            Lead Product(s): Mesenchymal Stem Cells

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: JadiCell

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 28, 2020

            Details:

            Using animal models, Company collaborators demonstrated stimulation of stem cell proliferation that reside in parts of the brain called the "dentate gyrus".

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            Lead Product(s): BA-1049

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: BA-1049

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 28, 2020

            Details:

            The latest notice covers the critical patent application (US 16/214,973) for the proprietary method of treatment of cerebral aneurysms with BA-1049 and other ROCK2 oral drug candidates now in development.

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            Lead Product(s): AV-001

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: AV-001

            Highest Development Status: Preclinical Product Type: Peptide

            Partner/Sponsor/Collaborator: US Department of Defense

            Deal Size: $2.8 million Upfront Cash: Undisclosed

            Deal Type: Funding August 18, 2020

            Details:

            Funding will support the development AV-001 for the treatment of COVID-19-associated acute lung injury and acute respiratory distress syndrome (ARDS).

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            Lead Product(s): Undisclosed

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 01, 2020

            Details:

            The study used mouse model to demonstrate that calpain-2 genetic deletion or blockade with NeurAegis' novel calpain-2 inhibitor eliminated the consequences of repeated concussions and protected the brain against neuroinflammation, neurodegeneration and cognitive impairment.