
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

Silexion Submits Phase 2/3 Trial for SIL204 in Advanced Pancreatic Cancer to Israel
Details : SIL-204, an oligonucleotide targeting KRAS G12D/V, shows promise in treating locally advanced pancreatic cancer (LAPC).
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
December 16, 2025

Silexion Completes Toxicology Studies for SIL204 Before Pancreatic Cancer Trial
Details : SIL-204, an oligonucleotide targeting KRAS G12D/V, shows promising results in treating undisclosed Key Focus Area.
Product Name : SIL204
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
November 25, 2025

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Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Silexion Therapeutics Confirms Pan-KRAS Activity of SIL204 with Up to 99.7% Inhibition
Details : SIL-204, an oligonucleotide targeting KRAS G12D/V, shows promising results in treating undisclosed Key Focus Area.
Product Name : SIL204
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
September 30, 2025
Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : H.C. Wainwright & Co
Deal Size : $6.0 million
Deal Type : Public Offering
Silexion Therapeutics Announces Pricing of $6.0 Million Public Offering
Details : The net proceeds will be used to advance the Company’s pre-clinical studies, including SIL-204, encapsulated in biodegradable PLGA MP, for direct release and injection into KRAS mutated solid tumors.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Undisclosed
September 11, 2025
Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : H.C. Wainwright & Co
Deal Size : $6.0 million
Deal Type : Public Offering

Silexion Reports 97% Cancer Cell Growth Inhibition, Including New KRAS Mutation
Details : SIL204 is a KRAS inhibitor siRNA candidate, which is being evaluated for the treatment of pancreatic cancer.
Product Name : SIL204
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
July 31, 2025

Silexion's SIL204 Shows Strong Preclinical Efficacy in Multiple Cancer Types
Details : Silexion is also advancing its next-generation siRNA candidate, SIL204, designed to target a broader range of KRAS mutations and showing significant potential in preclinical studies.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
May 29, 2025

Details : SIL204 is designed to inhibit the KRAS-driven oncogenic process, currently being investigated for patients with pancreatic cancers.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
May 29, 2025

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Lead Product(s) : SIL204
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Silexion Wraps Up Preclinical Studies of SIL204 for Lung and Colorectal Cancer
Details : Silexion is also advancing its next-generation siRNA candidate, SIL204, designed to target a broader range of KRAS mutations and showing significant potential in preclinical studies.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
May 21, 2025
Lead Product(s) : SIL204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Study Phase : Preclinical
Recipient : Catalent Pharma Solutions
Deal Size : Undisclosed
Deal Type : Collaboration
Silexion Partners with Catalent on Advanced siRNA Development
Details : The collaboration aims to advnace the clinical development of Silexion's SIL-204, which is a next-generation siRNA candidate. It is being evaluated for KRAS-mutated cancers.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Undisclosed
April 23, 2025
Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Recipient : Catalent Pharma Solutions
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Silexion Reports Positive SIL204 Data in Pancreatic Cancer Models
Details : SIL204 is an innovative RNA interference (RNAi) therapies, which is currently being evaluated for the treatment of solid tumors driven by KRAS mutations.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
March 05, 2025
Lead Product(s) : SIL-204
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
