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    Find Clinical Drug Pipeline Developments & Deals by Silexion Therapeutics

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                            01

                            Silexion Therapeutics

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                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silexion Therapeutics Confirms Pan-KRAS Activity of SIL204 with Up to 99.7% Inhibition

                            Details : SIL-204, an oligonucleotide targeting KRAS G12D/V, shows promising results in treating undisclosed Key Focus Area.

                            Product Name : SIL204

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            September 30, 2025

                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Silexion Therapeutics

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                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : H.C. Wainwright & Co

                            Deal Size : $6.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Silexion Therapeutics Announces Pricing of $6.0 Million Public Offering

                            Details : The net proceeds will be used to advance the Company’s pre-clinical studies, including SIL-204, encapsulated in biodegradable PLGA MP, for direct release and injection into KRAS mutated solid tumors.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Undisclosed

                            September 11, 2025

                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : H.C. Wainwright & Co

                            Deal Size : $6.0 million

                            Deal Type : Public Offering

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                            03

                            Silexion Therapeutics

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                            ISPOR Europe 2025
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                            Lead Product(s) : SIL204

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silexion Reports 97% Cancer Cell Growth Inhibition, Including New KRAS Mutation

                            Details : SIL204 is a KRAS inhibitor siRNA candidate, which is being evaluated for the treatment of pancreatic cancer.

                            Product Name : SIL204

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            July 31, 2025

                            Lead Product(s) : SIL204

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Silexion Therapeutics

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                            ISPOR Europe 2025
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                            Silexion Therapeutics

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                            Lead Product(s) : SIL204

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silexion's SIL204 Shows Strong Preclinical Efficacy in Multiple Cancer Types

                            Details : Silexion is also advancing its next-generation siRNA candidate, SIL204, designed to target a broader range of KRAS mutations and showing significant potential in preclinical studies.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            May 29, 2025

                            Lead Product(s) : SIL204

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Silexion Therapeutics

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                            Lead Product(s) : SIL204

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silexion Therapeutics Announces Groundbreaking Preclinical Results: SIL204 Shows Strong Efficacy in Pancreatic...

                            Details : SIL204 is designed to inhibit the KRAS-driven oncogenic process, currently being investigated for patients with pancreatic cancers.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            May 29, 2025

                            Lead Product(s) : SIL204

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Silexion Therapeutics

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                            Lead Product(s) : SIL204

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silexion Wraps Up Preclinical Studies of SIL204 for Lung and Colorectal Cancer

                            Details : Silexion is also advancing its next-generation siRNA candidate, SIL204, designed to target a broader range of KRAS mutations and showing significant potential in preclinical studies.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            May 21, 2025

                            Lead Product(s) : SIL204

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Silexion Therapeutics

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                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : Catalent Pharma Solutions

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Silexion Partners with Catalent on Advanced siRNA Development

                            Details : The collaboration aims to advnace the clinical development of Silexion's SIL-204, which is a next-generation siRNA candidate. It is being evaluated for KRAS-mutated cancers.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Undisclosed

                            April 23, 2025

                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : Catalent Pharma Solutions

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            08

                            Silexion Therapeutics

                            Israel arrow
                            ISPOR Europe 2025
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                            Silexion Therapeutics

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                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silexion Reports Positive SIL204 Data in Pancreatic Cancer Models

                            Details : SIL204 is an innovative RNA interference (RNAi) therapies, which is currently being evaluated for the treatment of solid tumors driven by KRAS mutations.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            March 05, 2025

                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Silexion Therapeutics

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                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silexion Completes Study on SIL-204 in Orthotopic Pancreatic Cancer Models

                            Details : SIL 204 is an anti KRAS G12D/V short-interfering RNA, which is being evaluated for KRAS G12D/V-mutated pancreatic neoplasms.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            February 25, 2025

                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Silexion Therapeutics

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                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Silexion Reports SIL-204 Reduces Pancreatic Tumor Growth

                            Details : SIL-204 is a next-generation siRNA therapeutic candidate administered subcutaneously inhibited tumor growth in KRAS G12D/V-mutated pancreatic neoplasms mouse models.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            January 28, 2025

                            Lead Product(s) : SIL-204

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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