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California Institute for Regenerative Medicine"},{"orgOrder":0,"company":"Senti Biosciences","sponsor":"GeneFab","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2023","type":"Acquisition","leadProduct":"SENTI-202","moa":"CD33\/FLT3","graph1":"Oncology","graph2":"Phase I","graph3":"Senti Biosciences","amount2":0.040000000000000001,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.040000000000000001,"dosageForm":"Inhalation","sponsorNew":"Senti Biosciences \/ GeneFab","highestDevelopmentStatusID":"6","companyTruncated":"Senti Biosciences \/ GeneFab"},{"orgOrder":0,"company":"Senti Biosciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2023","type":"Inapplicable","leadProduct":"SENTI-202","moa":"CD33\/FLT3","graph1":"Oncology","graph2":"Phase I","graph3":"Senti 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Biosciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"SENTI-202","moa":"CD33\/FLT3","graph1":"Oncology","graph2":"Phase I","graph3":"Senti Biosciences","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Senti Biosciences \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Senti Biosciences \/ Undisclosed"},{"orgOrder":0,"company":"Senti Biosciences","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"SENTI-202","moa":"CD33\/FLT3","graph1":"Oncology","graph2":"Phase I","graph3":"Senti Biosciences","amount2":0,"highestDevelopmentShortName":"Ph 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                          Top Deals by Deal Size (USD bn)

                          01

                          Fall Technical Meeting
                          Not Confirmed
                          Fall Technical Meeting
                          Not Confirmed

                          Details : Senti Bio will support the clinical development of SENTI-202, a potential first-in-class Logic Gated off-the-shelf CAR-NK cell therapy, for relapsed/refractory hematologic malignancies including AML.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          May 22, 2025

                          Lead Product(s) : SENTI-202

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : CIRM

                          Deal Size : $8.0 million

                          Deal Type : Funding

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                          02

                          Fall Technical Meeting
                          Not Confirmed
                          Fall Technical Meeting
                          Not Confirmed

                          Details : SENTI-202 is a first-in-class off-the-shelf logic gated selective CD33 OR FLT3 cell therapy product candidate which eliminates CD33 and/or FLT3-expressing hematologic malignancies, such as AML.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          April 28, 2025

                          Lead Product(s) : SENTI-202,Cytarabine,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Fall Technical Meeting
                          Not Confirmed
                          Fall Technical Meeting
                          Not Confirmed

                          Details : The Company intends to use the net proceeds from the offering to fund the continued development of its SENTI-202 program for treating acute myeloid leukemia.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          January 06, 2025

                          Lead Product(s) : SENTI-202

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Celadon Partners

                          Deal Size : $47.6 million

                          Deal Type : Financing

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                          04

                          Fall Technical Meeting
                          Not Confirmed
                          Fall Technical Meeting
                          Not Confirmed

                          Details : The net proceeds will be used to fund the clinical development of the company's lead product SENTI-202, which is being evaluated for the treatment of acute myeloid leukemia & Hematologic Malignancies

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          December 02, 2024

                          Lead Product(s) : SENTI-202

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Celadon Partners

                          Deal Size : $37.6 million

                          Deal Type : Private Placement

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                          05

                          Fall Technical Meeting
                          Not Confirmed
                          Fall Technical Meeting
                          Not Confirmed

                          Details : SENTI-202 is a potential first-in-class off-the-shelf CAR-NK cell therapy which selectively target cancer cells while sparing healthy bone marrow cells. It is being evaluated for the treatment of AML.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          December 02, 2024

                          Lead Product(s) : SENTI-202

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Fall Technical Meeting
                          Not Confirmed
                          Fall Technical Meeting
                          Not Confirmed

                          Details : The CIRM grant will support the ongoing clinical development of SENTI-202, which is being evaluated in early-stage clinical trial studies for treating acute myeloid leukemia.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          August 05, 2024

                          Lead Product(s) : SENTI-202

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : California Institute for Regenerative Medicine

                          Deal Size : $8.0 million

                          Deal Type : Funding

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                          07

                          Fall Technical Meeting
                          Not Confirmed
                          Fall Technical Meeting
                          Not Confirmed

                          Details : The proceeds will advance the development of SENTI-202, a potential first-in-class Logic Gated off-the-shelf CAR-NK cell therapy, for relapsed/refractory hematologic malignancies including AML.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          July 01, 2024

                          Lead Product(s) : SENTI-202,Cytarabine,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : California Institute for Regenerative Medicine

                          Deal Size : $8.0 million

                          Deal Type : Funding

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                          08

                          Fall Technical Meeting
                          Not Confirmed
                          Fall Technical Meeting
                          Not Confirmed

                          Details : SENTI-202 is a Logic Gated off-the-shelf CAR-NK cell therapy designed to selectively target and eliminate CD33 and/or FLT3 expressing hematologic malignancies, such as acute myeloid leukemia.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          May 13, 2024

                          Lead Product(s) : SENTI-202

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Fall Technical Meeting
                          Not Confirmed
                          Fall Technical Meeting
                          Not Confirmed

                          Details : SENTI-202 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Amyotrophic Lateral Sclerosis.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          March 22, 2024

                          Lead Product(s) : SENTI-202

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Fall Technical Meeting
                          Not Confirmed
                          Fall Technical Meeting
                          Not Confirmed

                          Details : SENTI-202 is an off-the-shelf chimeric antigen receptor natural killer (CAR-NK) cell therapy product candidate designed to selectively target and eliminate CD33 and/or FLT3 expressing hematologic malignancies including acute myeloid leukemia.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          December 22, 2023

                          Lead Product(s) : SENTI-202

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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