Drugs in Dev.
Psychiatry/Psychology
Phase I
Japan 
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Lead Product(s) : HTL0039732
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Boehringer Ingelheim GmbH
Deal Size : $732.5 million
Deal Type : Collaboration
Boehringer and Sosei Heptares Collaborate on First-In-Class Schizophrenia Treatments
Details : The collaboration aims to focus on the development of HTL0048149, which is a GPR52 agonist. Currently it being evaluated with patients for the treatment of Schizophrenia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : $27.3 million
March 11, 2024
Lead Product(s) : HTL0039732
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Boehringer Ingelheim GmbH
Deal Size : $732.5 million
Deal Type : Collaboration

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Lead Product(s) : Brexpiprazole Fumarate
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Food Effect Study of Brexpiprazole Once-weekly (QW) Formulation in Patients With Schizophrenia
Details : Brexpiprazole Fumarate is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Schizophrenia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
September 13, 2023
Lead Product(s) : Brexpiprazole Fumarate
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : HTL’149
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : HTL’149 was developed by StaR® technology and SBDD platform, as a once-daily, orally available small molecule and selectively targeting the orphan GPR52 receptor, which is investigated for Schizophrenia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
July 03, 2023
Lead Product(s) : HTL’149
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Ulotaront
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
A Clinical Study to Learn if SEP-363856 Has Physical Dependence in Adults With Schizophrenia
Details : SEP-363856 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Schizophrenia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
May 08, 2023
Lead Product(s) : Ulotaront
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Ulotaront
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : SEP-363856 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Schizophrenia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
September 15, 2022
Lead Product(s) : Ulotaront
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : NBI-1117568
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Neurocrine Biosciences
Deal Size : $2,700.0 million
Deal Type : Collaboration
Details : NBI-1117568 (previously known as HTL-0016878 ) is an oral, selective muscarinic M4 receptor agonist in development for the treatment of schizophrenia and other neuropsychiatric disorders. Clinical studies completed to date have shown NBI-1117568 to be ge...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : $100.0 million
August 05, 2022
Lead Product(s) : NBI-1117568
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Neurocrine Biosciences
Deal Size : $2,700.0 million
Deal Type : Collaboration

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Lead Product(s) : Ulotaront
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : SEP-363856 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Schizophrenia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
July 19, 2022
Lead Product(s) : Ulotaront
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Ulotaront
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : SEP-363856 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Schizophrenia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
June 02, 2022
Lead Product(s) : Ulotaront
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Propranolol Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : IQVIA
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Propranolol is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Stress Disorders, Post-Traumatic.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
January 13, 2022
Lead Product(s) : Propranolol Hydrochloride
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : IQVIA
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : HTL0016878
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Neurocrine Biosciences
Deal Size : $2,700.0 million
Deal Type : Licensing Agreement
Sosei Heptares Announces Antitrust Clearance of License Agreement with Neurocrine Biosciences
Details : HTL0016878 was designed by Heptares using its proprietary structure-based drug design platform and is the first compound, selected from a series of selective M4 agonists, to progress into clinical studies.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : $100.0 million
December 24, 2021
Lead Product(s) : HTL0016878
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Neurocrine Biosciences
Deal Size : $2,700.0 million
Deal Type : Licensing Agreement
