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    [{"orgOrder":0,"company":"Prokarium","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"Salmonella Typhi","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Prokarium","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Prokarium \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"Prokarium \/ Undisclosed"},{"orgOrder":0,"company":"Prokarium","sponsor":"Prokarium","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"SWITZERLAND","productType":"Microorganism","year":"2020","type":"Licensing Agreement","leadProduct":"Salmonella Typhi Ty21a","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Prokarium","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Prokarium \/ Prokarium","highestDevelopmentStatusID":"4","companyTruncated":"Prokarium \/ Prokarium"},{"orgOrder":0,"company":"Prokarium","sponsor":"Korea Investment Partners","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2020","type":"Series B Financing","leadProduct":"Vesibax","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Prokarium","amount2":0.02,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0.02,"dosageForm":"Undisclosed","sponsorNew":"Prokarium \/ Korea Investment Partners","highestDevelopmentStatusID":"4","companyTruncated":"Prokarium \/ Korea Investment Partners"},{"orgOrder":0,"company":"Prokarium","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2023","type":"Inapplicable","leadProduct":"ZH9","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"Prokarium","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Prokarium \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Prokarium \/ Undisclosed"},{"orgOrder":0,"company":"Prokarium","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Vaccine","year":"2024","type":"Inapplicable","leadProduct":"ZH9","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"Prokarium","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Prokarium \/ 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I","graph3":"Prokarium","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Prokarium \/ Simbec Research","highestDevelopmentStatusID":"6","companyTruncated":"Prokarium \/ Simbec Research"},{"orgOrder":0,"company":"Prokarium","sponsor":"Prokarium","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"SWITZERLAND","productType":"Undisclosed","year":"2022","type":"Licensing Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Prokarium","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Prokarium \/ Prokarium","highestDevelopmentStatusID":"4","companyTruncated":"Prokarium \/ Prokarium"},{"orgOrder":0,"company":"Prokarium","sponsor":"Ginkgo Bioworks","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2023","type":"Partnership","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Discovery","graph3":"Prokarium","amount2":0,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Prokarium \/ Ginkgo Bioworks","highestDevelopmentStatusID":"2","companyTruncated":"Prokarium \/ Ginkgo Bioworks"},{"orgOrder":0,"company":"Prokarium","sponsor":"Ginkgo Bioworks","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2023","type":"Financing","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"IND Enabling","graph3":"Prokarium","amount2":0.029999999999999999,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0.029999999999999999,"dosageForm":"Undisclosed","sponsorNew":"Prokarium \/ Ginkgo Bioworks","highestDevelopmentStatusID":"5","companyTruncated":"Prokarium \/ Ginkgo Bioworks"}]

    Find Clinical Drug Pipeline Developments & Deals by Prokarium

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                            01

                            Prokarium

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                            Lead Product(s) : ZH9

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prokarium Doses First Patient in PARADIGM-1 Trial for Non-Muscle Invasive Bladder Cancer

                            Details : ZH9 is a live attenuated S. enterica serovar Typhi ZH9, a differentiated novel microbial immunotherapy. It is being evaluated in phase 1 clinical trials for non-muscle invasive bladder cancer.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            February 07, 2024

                            Lead Product(s) : ZH9

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Prokarium

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                            Lead Product(s) : ZH9

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Phase 1/1b Study of ZH9 Treatment in Patients With Non-Muscle Invasive Bladder Cancer

                            Details : ZH9 is a Vaccine drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Non-Muscle Invasive Bladder Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            December 26, 2023

                            Lead Product(s) : ZH9

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Prokarium

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                            Lead Product(s) : ZH9

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prokarium Achieves Major Milestone with FDA's IND Approval for Bladder Cancer Program

                            Details : ZH9 is being developed as an intravesical monotherapy treatment for the prevention of recurrences in bladder cancer. The PARADIGM-1 study is expected to enroll in H1 2024 across multiple centers in the United States.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            November 02, 2023

                            Lead Product(s) : ZH9

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Prokarium

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Ginkgo Bioworks

                            Deal Size : $30.0 million

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Prokarium Announces $30 Million Financing to Deliver Lead Program into Clinic and Build Novel Therapeutic Plat...

                            Details : Proceeds will support clinical development of the Company’s lead oncology candidate in non-muscle invasive bladder cancer and accelerate platform discovery.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            February 09, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Ginkgo Bioworks

                            Deal Size : $30.0 million

                            Deal Type : Financing

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                            05

                            Prokarium

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                            AIChE Annual Meeting
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Discovery

                            Sponsor : Ginkgo Bioworks

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            Prokarium and Ginkgo Bioworks Announce Partnership to Discover Multiple Targets for RNA Therapeutics and Immun...

                            Details : Bactofection, the process of transferring genetic material into a mammalian cell via a bacterium, is an alternative gene delivery system that could deliver therapeutic agents to a patient in RNA-based therapy.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            January 09, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Discovery

                            Sponsor : Ginkgo Bioworks

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            06

                            Prokarium

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                            Lead Product(s) : Salmonella Typhi

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Prokarium Strengthens Patent Position Through Notice of Allowance of US Patent for Immunotherapy Prime in Comb...

                            Details : Salmonella Typhi delivered orally with an adoptive T cell therapy or an allogeneic or autologous CAR T-cell therapy to increase the therapeutic efficacy of the cell therapy.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            October 05, 2022

                            Lead Product(s) : Salmonella Typhi

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Prokarium

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : Lausanne University Hospital

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Prokarium Exercises Option for an Exclusive Worldwide License for the Use of Salmonella Immunotherapy in the T...

                            Details : Department of Urology at CHUV has generated a robust preclinical data package demonstrating that Prokarium’s proprietary Salmonella bacteria generates quantitatively and qualitatively superior immune responses with different kinetics compared to the st...

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            March 02, 2022

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : Lausanne University Hospital

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            08

                            Prokarium

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                            Lead Product(s) : Vesibax

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Korea Investment Partners

                            Deal Size : $21.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            Prokarium Closes $21M Series B Financing Round and Strengthens Board

                            Details : Financing will support the clinical development of Prokarium’s microbial immunotherapy for non-muscle invasive bladder cancer as well as expansion of pipeline across multiple solid tumours.

                            Product Name : Vesibax

                            Product Type : Vaccine

                            Upfront Cash : Undisclosed

                            October 27, 2020

                            Lead Product(s) : Vesibax

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Korea Investment Partners

                            Deal Size : $21.0 million

                            Deal Type : Series B Financing

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                            09

                            Prokarium

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                            Lead Product(s) : Salmonella Typhi Ty21a

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : Lausanne University Hospital

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Prokarium Signs an Exclusive Option Agreement with the Lausanne University Hospital for the Treatment of Non-M...

                            Details : Agreement with the Lausanne University Hospital gives Prokarium access to a license to cover the treatment of Non-Muscle Invasive Bladder Cancer patients with intravesical instillations of Salmonella.

                            Product Name : Undisclosed

                            Product Type : Microorganism

                            Upfront Cash : Undisclosed

                            April 28, 2020

                            Lead Product(s) : Salmonella Typhi Ty21a

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : Lausanne University Hospital

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            10

                            Prokarium

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                            Lead Product(s) : ZH9PA

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I

                            Sponsor : Simbec Research

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study to Evaluate the Safety, Tolerability and Immunogenicity of a Potential Enteric Fever Vaccine

                            Details : ZH9PA is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Typhoid Fever.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            April 16, 2020

                            Lead Product(s) : ZH9PA

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I

                            Sponsor : Simbec Research

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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