[{"company":"Valo Therapeutics","sponsor":"Finnish Funding Agency for Innovation","pharmaFlowCategory":"D","amount":"$10.9 million","upfrontCash":"$1.2 million","newsHeadline":"Valo Therapeutics Announces New Funding for Immuno-Oncology Trials","therapeuticArea":"Oncology","highestDevelopmentStatus":"Preclinical","country":"UNITED KINGDOM","productType":"Vaccine","productStatus":"New Molecular Entity","date":"February 2020","url1":"","url2":"","graph1":"Vaccine","graph2":"Valo Therapeutics"},{"company":"Aptorum","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Aptorum Group Announces Significant Progress of SACT-1","therapeuticArea":"Oncology","highestDevelopmentStatus":"Preclinical","country":"UNITED KINGDOM","productType":"Undisclosed","productStatus":"New Molecular Entity","date":"February 2020","url1":"","url2":"","graph1":"Undisclosed","graph2":"Aptorum"},{"company":"F-star Therapeutics","sponsor":"Not 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Group"},{"company":"F-star Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"F-star Therapeutics Presents Data on FS222 at 2020 AACR Annual Meeting","therapeuticArea":"Oncology","highestDevelopmentStatus":"Preclinical","country":"UNITED KINGDOM","productType":"Large molecule","productStatus":"New Molecular Entity","date":"June 2020","url1":"","url2":"","graph1":"Large molecule","graph2":"F-star Therapeutics"},{"company":"F-star Therapeutics","sponsor":"Merck Group","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"F-star Therapeutics: Merck KGaA, Darmstadt, Germany Takes an Early Option in Immuno-Oncology Collaboration","therapeuticArea":"Oncology","highestDevelopmentStatus":"Preclinical","country":"UNITED KINGDOM","productType":"Large molecule","productStatus":"Undisclosed","date":"July 2020","url1":"","url2":"","graph1":"Large molecule","graph2":"F-star 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Details:
Oxilio has since progressed the product and now signed a significant service contract with Quotient Sciences, a drug development and manufacturing accelerator, to support the formulation development and preparation of clinical trials for OXL001.
Lead Product(s):
OXL001
Therapeutic Area: Oncology
Product Name: OXL001
Highest Development Status: Preclinical
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Oxilio
Deal Size: Undisclosed
Upfront Cash: Undisclosed
Deal Type: Agreement
February 18, 2022
Details:
EXALT-1 was the rst prospective trial to demonstrate signicantly improved outcomes for late-stage haematological cancer patients using an AI-supported precision medicine platform to guide personalised treatment recommendations as compared to physician’s choice of treatment.
Lead Product(s):
Undisclosed
Therapeutic Area: Oncology
Product Name: Undisclosed
Highest Development Status: Preclinical
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
September 20, 2022
Details:
AVA6000 is form of generic chemotherapy doxorubicin that has been modified using the pre|CISION technology so that it is activated predominantly in tumour with aim of sparing healthy tissue from exposure and improving the safety, tolerability and efficacy of drug.
Lead Product(s):
FAP Activated Doxorubicin Prodrug
Therapeutic Area: Oncology
Product Name: AVA6000
Highest Development Status: Preclinical
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
September 05, 2022
Details:
Under the terms of the agreement, LG Chem has the exclusive rights to develop and commercialise, on a global basis, Avacta’s Affimer® PD-L1 inhibitor (PD-L1 XT) with Affimer XT™ serum half-life extension for a range of indications.
Lead Product(s):
PD-L1 XT
Therapeutic Area: Oncology
Product Name: PD-L1 XT
Highest Development Status: Preclinical
Product Type: Large molecule
Partner/Sponsor/Collaborator:
LG Chem
Deal Size: Undisclosed
Upfront Cash: Undisclosed
Deal Type: Expanded Collaboration
June 30, 2022
Details:
The antibodies generated by OBT have been coupled with ImmunoGen's proprietary linker-payload technology, each company will have the opportunity to select one or more development programs including lead OBT0227/OBT227, to further develop on its own.
Lead Product(s):
OBT227
Therapeutic Area: Oncology
Product Name: OBT0227
Highest Development Status: Preclinical
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Immunogen
Deal Size: Undisclosed
Upfront Cash: Undisclosed
Deal Type: Collaboration
June 13, 2022
Details:
The nine presentations highlight the progress the Company has made in modulating exosome pharmacokinetics through extension of circulation half-life and improved tissue-targeting via display of ligands on Antibody-loaded Exosomes.
Lead Product(s):
Antibody-loaded Exosomes
Therapeutic Area: Oncology
Product Name: Undisclosed
Highest Development Status: Preclinical
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
May 25, 2022
Details:
Antibody-loaded exosomes, which covered recent advances on engineering exosomes as a display platform for biologics, new in vivo data on antibody-directed targeting of exosomes to tumours, and new data supporting the concept of in situ produced drug-loaded exosomes.
Lead Product(s):
Antibody-loaded Exosomes
Therapeutic Area: Oncology
Product Name: Undisclosed
Highest Development Status: Preclinical
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
May 09, 2022
Details:
Portage, Stimunity and NCI will collaborate with Center for Cancer Research to advance preclinical and clinical development of STING agonists, STI-001 and anti-Receptor for Advanced Glycation End products agents, for possible synergy to enhance the efficacy of cancer vaccines.
Lead Product(s):
STI-001,Undisclosed
Therapeutic Area: Oncology
Product Name: STI-001
Highest Development Status: Preclinical
Product Type: Large molecule
Partner/Sponsor/Collaborator:
National Cancer Institute
Deal Size: Undisclosed
Upfront Cash: Undisclosed
Deal Type: Collaboration
April 25, 2022
Details:
Exscientia designed an orally bioavailable, highly potent and selective small-molecule antagonist of CDK7, GTAEXS-617, currently in IND-enabling studies as a potential treatment for transcriptionally addicted cancers, including EXS21546.
Lead Product(s):
GTAEXS-617
Therapeutic Area: Oncology
Product Name: EXS21546
Highest Development Status: Preclinical
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
April 08, 2022
Details:
TNP – composed of proprietary polymer capsule ‘OM-PBAE’ polymers (oligopeptide end-modified poly β-amino-ester polymers) directed to specific cells through targeting agents attached capsule (an aptamer-based targeting moiety) and celtic (Lentivirus Based CAR T-cell Therapy).
Lead Product(s):
Lentivirus Based CAR T-cell Therapy
Therapeutic Area: Oncology
Product Name: Celtic
Highest Development Status: Preclinical
Product Type: Cell and Gene therapy
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
March 21, 2022
Market Place
News Type
Molecule to Cure. Fast. 
