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Cancer Research","sponsor":"Oracle Cancer Trust","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"PLX4720","moa":"||Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"The Institute of Cancer Research","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"The Institute of Cancer Research \/ Oracle Cancer Trust","highestDevelopmentStatusID":"4","companyTruncated":"The Institute of Cancer Research \/ Oracle Cancer Trust"}]

Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : OXL001

                          Therapeutic Area : Oncology

                          Study Phase : Preclinical

                          Sponsor : Oxilio

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Details : Oxilio has since progressed the product and now signed a significant service contract with Quotient Sciences, a drug development and manufacturing accelerator, to support the formulation development and preparation of clinical trials for OXL001.

                          Product Name : OXL001

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 18, 2022

                          Lead Product(s) : OXL001

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Oxilio

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Quotient

                          02

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : The net proceeds from the placement will be used to support the clinical development of AKTX-101, is a novel payload is a spliceosome inhibitor. It is being evaluating for treating neoplasms.

                          Product Name : AKTX-101

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Undisclosed

                          March 03, 2025

                          Lead Product(s) : AKTX-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Paulson Investment Company

                          Deal Size : $7.6 million

                          Deal Type : Private Placement

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                          03

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : The financing will accelerate the lead asset, Jankistomig, a PD1/VEGFR2 bifunctional antibody for multiple solid tumor indications and a pipeline of follow-on bifunctional assets.

                          Product Name : Undisclosed

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          December 19, 2024

                          Lead Product(s) : Jankistomig

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : OrbiMed Advisors

                          Deal Size : $140.0 million

                          Deal Type : Series A Financing

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                          04

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : The agreement aims for clinical trial production of GNX102-ADC in preparation for a planned Phase 1 clinical program investigating the drug technology.

                          Product Name : GNX102-ADC

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          December 11, 2024

                          Lead Product(s) : GNX102-ADC

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : GlycoNex

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          05

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : The net proceeds from the funding will be used to advance the development of company's Cryptigen immunotherapeutics, discovered by Epitopea’s CryptoMap platform, for cancer.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          December 09, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Innovate Biopharmaceuticals

                          Deal Size : $0.6 million

                          Deal Type : Funding

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                          06

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : Trogenix lead product candidate is being evaluated in preclinical studies for the treatment of patients with aggressive cancers including glioblastoma.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          November 18, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : Ottimo is developing Jankistomig, a PD1-VEGFR2 bi-functional antibody, designed as a dual-pathway, IgG therapy targeting immune checkpoint inhibition and angiogenesis in the treatment of cancer.

                          Product Name : Undisclosed

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          October 28, 2024

                          Lead Product(s) : Jankistomig

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : The proceeds will be used to advance the Company’s immunomodulatory alpha neutrophils (IMANs) into clinical trials, a type of super enhanced neutrophil that can kill cancer cells.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          September 23, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Sijbrandij Foundation

                          Deal Size : $13.1 million

                          Deal Type : Series A Financing

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                          09

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : The proceeds will be used to accelerate the development of company's MST-0300, a first-in-class bispecific antibody designed to induce TLS in solid tumors.

                          Product Name : MST-0300

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          August 29, 2024

                          Lead Product(s) : MST-0300

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Innovate Biopharmaceuticals

                          Deal Size : $1.9 million

                          Deal Type : Funding

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                          10

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : The proceeds will be used to accelerate the development of drug discovery programmes in the area of DNA damage response, towards clinical Proof of Concept.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          August 01, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Eos Advisory

                          Deal Size : $11.4 million

                          Deal Type : Financing

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