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III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Daiichi Sankyo \/ AstraZeneca","highestDevelopmentStatusID":"10","companyTruncated":"Daiichi Sankyo \/ AstraZeneca"},{"orgOrder":0,"company":"Daiichi Sankyo","sponsor":"AstraZeneca","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"JAPAN","productType":"Antibody-drug Conjugate","year":"2021","type":"Inapplicable","leadProduct":"Datopotamab Deruxtecan","moa":"DNA topoisomerase I","graph1":"Oncology","graph2":"Phase III","graph3":"Daiichi Sankyo","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Daiichi Sankyo \/ AstraZeneca","highestDevelopmentStatusID":"10","companyTruncated":"Daiichi Sankyo \/ AstraZeneca"},{"orgOrder":0,"company":"Kissei Pharmaceutical","sponsor":"CG Oncology","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"JAPAN","productType":"Microorganism","year":"2021","type":"Inapplicable","leadProduct":"Cretostimogene Grenadenorepvec","moa":"GM-CSF","graph1":"Oncology","graph2":"Phase III","graph3":"Kissei Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Kissei Pharmaceutical \/ CG Oncology","highestDevelopmentStatusID":"10","companyTruncated":"Kissei Pharmaceutical \/ CG Oncology"},{"orgOrder":0,"company":"Daiichi Sankyo","sponsor":"Merck & Co","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"JAPAN","productType":"Antibody-drug Conjugate","year":"2025","type":"Inapplicable","leadProduct":"Ifinatamab deruxtecan","moa":"B7-H3","graph1":"Oncology","graph2":"Phase III","graph3":"Daiichi Sankyo","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Daiichi Sankyo \/ Merck & Co","highestDevelopmentStatusID":"10","companyTruncated":"Daiichi Sankyo \/ Merck & Co"}]

Find Oncology Drugs in Phase III Clinical Development in JAPAN

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Discovery Europe
                          Not Confirmed
                          Discovery Europe
                          Not Confirmed

                          Details : I-DXd (ifinatamab deruxtecan) is comprised of a humanized anti-B7-H3 IgG1 monoclonal antibody being investigated for unresectable advanced or metastatic esophageal squamous cell carcinoma.

                          Product Name : I-DXd

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Inapplicable

                          May 19, 2025

                          Lead Product(s) : Ifinatamab deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Discovery Europe
                          Not Confirmed
                          Discovery Europe
                          Not Confirmed

                          Details : Enhertu (trastuzumab deruxtecan) in combination with fluoropyrimidine chemotherapy, pembrolizumab is being studied for unresectable, locally advanced or metastatic HER2 positive gastric or GEJ cancer.

                          Product Name : Enhertu

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Inapplicable

                          March 31, 2025

                          Lead Product(s) : Trastuzumab Deruxtecan,Cisplatin,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Discovery Europe
                          Not Confirmed
                          Discovery Europe
                          Not Confirmed

                          Details : Datroway (datopotamab deruxtecan), an TROP2 ADC, plus rilvegostomig, A PD-1/TIGIT bispecific antibody, is being investigated in patients with stage 1 adenocarcinoma non-small cell lung cancer.

                          Product Name : Datroway

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Inapplicable

                          January 30, 2025

                          Lead Product(s) : Datopotamab Deruxtecan,Rilvegostomig

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : AstraZeneca

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Discovery Europe
                          Not Confirmed
                          Discovery Europe
                          Not Confirmed

                          Details : Dato-DXd (datopotamab deruxtecan) is a DNA topoisomerase I inhibitor candidate, which is being developed in patients with EGFR-mutated non-small cell lung cancer.

                          Product Name : Dato-DXd

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Inapplicable

                          January 13, 2025

                          Lead Product(s) : Datopotamab Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Discovery Europe
                          Not Confirmed
                          Discovery Europe
                          Not Confirmed

                          Details : Dato-DXd (datopotamab deruxtecan) is a DNA topoisomerase I inhibitor candidate, which is being developed in patients with EGFR-mutated non-small cell lung cancer.

                          Product Name : Dato-DXd

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Inapplicable

                          December 09, 2024

                          Lead Product(s) : Datopotamab Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : AstraZeneca

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Discovery Europe
                          Not Confirmed
                          Discovery Europe
                          Not Confirmed

                          Details : Dato-DXd (datopotamab deruxtecan) is a DNA topoisomerase I inhibitor candidate, which is being developed in patients with EGFR-mutated non-small cell lung cancer.

                          Product Name : Dato-DXd

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Inapplicable

                          December 05, 2024

                          Lead Product(s) : Datopotamab Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : AstraZeneca

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Discovery Europe
                          Not Confirmed
                          Discovery Europe
                          Not Confirmed

                          Details : DFP-14323 (Ubenimex) is a small molecule CD13 inhibitor, currently being investigated in combination with Afatinib for patients with EGFR-mutated Non-Small-Cell Lung Cancer.

                          Product Name : DFP-14323

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          November 26, 2024

                          Lead Product(s) : ubenimex,Afatinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Discovery Europe
                          Not Confirmed
                          Discovery Europe
                          Not Confirmed

                          Details : Enhertu (trastuzumab deruxtecan) is a HER2-directed ADC which is being evaluated for the treatment of previously treated patients with HR positive, HER2 low metastatic breast cancer.

                          Product Name : Enhertu

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Inapplicable

                          September 30, 2024

                          Lead Product(s) : Trastuzumab Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : AstraZeneca

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Discovery Europe
                          Not Confirmed
                          Discovery Europe
                          Not Confirmed

                          Details : Vyloy (zolbetuximab) is a chimeric IgG1 monoclonal antibody that binds to CLDN18.2. It is being evaluated for HER2-negative gastric or gastroesophageal junction adenocarcinoma.

                          Product Name : IMAB362

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          September 20, 2024

                          Lead Product(s) : Zolbetuximab,Capecitabine,Oxaliplatin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Discovery Europe
                          Not Confirmed
                          Discovery Europe
                          Not Confirmed

                          Details : U3-1402 (patritumab deruxtecan) is an investigational HER3 directed ADC. It is under development for EGFR-mutated locally advanced or metastatic non-small cell lung cancer.

                          Product Name : U3-1402

                          Product Type : Antibody-drug Conjugate

                          Upfront Cash : Inapplicable

                          September 17, 2024

                          Lead Product(s) : Patritumab Deruxtecan

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Merck & Co

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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