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Lymphoma","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"SINGAPORE","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"December 2022","url1":"","url2":"","graph1":"Cell and Gene therapy","graph2":"Tessa Therapeutics"}]

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            Details:

            Teliso-V, an investigational antibody-drug conjugate (ADC), is being studied in patients with previously treated non-small cell lung cancer (NSCLC) with c-Met overexpression.

            Lead Product(s): Telisotuzumab Vedotin

            Therapeutic Area: Oncology Product Name: Teliso-V

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 04, 2022

            Abbvie Company Banner

            TMF Summit 2024

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            Ibrutinib plus venetoclax is an investigational fixed-duration combination. Patients received 3 cycles of ibrutinib lead-in followed by 12 cycles of ibrutinib + venetoclax (Ibr 420 mg/day PO; Ven ramp up to 400 mg/day PO).

            Lead Product(s): Venetoclax,Ibrutinib

            Therapeutic Area: Oncology Product Name: Venclexta

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 07, 2021

            Abbvie Company Banner

            TMF Summit 2024

            Not Confirmed

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            The results show the ibrutinib plus venetoclax combination providing continued disease-free survival for CLL patients once treatment is complete.

            Lead Product(s): Ibrutinib,Venetoclax

            Therapeutic Area: Oncology Product Name: Imbruvica

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Johnson & Johnson Innovative Medicine

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 05, 2020

            Abbvie Company Banner

            TMF Summit 2024

            Not Confirmed

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            AbbVie will present updated results from the CAPTIVATE study, evaluating disease-free survival in previously untreated patients with chronic lymphocyctic leukemia/small lymphocytic leukemia who received ibrutinib (IMBRUVICA®) + venetoclax (VENCLEXTA®/ VENCLYXTO®) regimen.

            Lead Product(s): Venetoclax,Ibrutinib

            Therapeutic Area: Oncology Product Name: Venclexta

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 05, 2020

            Abbvie Company Banner

            TMF Summit 2024

            Not Confirmed

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            Details:

            AUM001 is a mRNA translation inhibitor that targets MNK 1/2 and the chokepoint of multiple pro-oncogenic signalling pathways, being investigated for the treatment of metastatic colorectal cancer.

            Lead Product(s): AUM001,Pembrolizumab,Irinotecan Hydrochloride

            Therapeutic Area: Oncology Product Name: AUM001

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 30, 2023

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            The results demonstrated TT11 to be well-tolerated with promising efficacy in relapsed or refractory (r/r) CD30-positive classical Hodgkin lymphoma (cHL). The CD30.CAR-T cell therapy was demonstrated to be well tolerated with no unexpected safety signals.

            Lead Product(s): CD30.CAR-T,Fludarabine Phosphate,Bendamustine Hydrochloride

            Therapeutic Area: Oncology Product Name: TT11

            Highest Development Status: Phase II Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 12, 2022

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            AUM001 is highly selective translation inhibitor. In vitro, it was observed to selectively inhibit MAPK – interacting protein kinase (MNK) types 1/2 and is expected to thereby block phosphorylation of eIF4E, and in turn, interfere with CAP mediated RNA translation.

            Lead Product(s): AUM001,Pembrolizumab

            Therapeutic Area: Oncology Product Name: AUM001

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 15, 2022

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            TT11 – is an autologous CD30 targeting CAR-T therapy currently being investigated as a potential treatment for relapsed or refractory classical Hodgkin lymphoma.

            Lead Product(s): CD30.CAR-T,Fludarabine Phosphate,Bendamustine Hydrochloride

            Therapeutic Area: Oncology Product Name: TT11

            Highest Development Status: Phase II Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 13, 2022

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            Details:

            Tessa plans to use the proceeds from the financing to advance the ongoing clinical development of the company’s autologous CD30-CAR-T therapy (TT11) and allogeneic CD30.CAR EBVST therapy (TT11X) programs.

            Lead Product(s): CD30.CAR-T,Fludarabine Phosphate,Bendamustine Hydrochloride

            Therapeutic Area: Oncology Product Name: TT11

            Highest Development Status: Phase II Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Polaris Partners

            Deal Size: $126.0 million Upfront Cash: Undisclosed

            Deal Type: Series A Financing June 09, 2022

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            This collaboration with MSD marks a major milestone and enables the joint clinical development of AUM001 in combination with KEYTRUDA. As a monotherapy, AUM001 demonstrated encouraging safety, tolerability and target engagement in two Phase 1 studies.

            Lead Product(s): AUM001,Pembrolizumab

            Therapeutic Area: Oncology Product Name: AUM001

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: MSD Pharmaceuticals

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration May 05, 2022

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