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BNT325\/DB-1305","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"GERMANY","productType":"Large molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Large molecule","graph2":"BioNTech"},{"orgOrder":0,"company":"Bayer AG","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Bayer Receives U.S. FDA Breakthrough Therapy Designation for BAY 2927088 for Non-Small Cell Lung Cancer Harboring HER2 Activating Mutations","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"GERMANY","productType":"Small molecule","productStatus":"New Molecular Entity","date":"February 2024","url1":"","url2":"","graph1":"Small molecule","graph2":"Bayer AG"}]
Find Oncology Drugs in Phase I/II Clinical Development in GERMANY
BAY 2927088 is an oral, small molecule tyrosine kinase inhibitor, which is being evaluated for the treatment of non-small cell lung cancer harboring HER2 activating mutations.
DB-1305 (BNT325) is a next-generation antibody-drug conjugate (“ADC”) candidate targeting the TROP2. It is being evaluated in phase 1/2 clinical trials for the treatment of patients with platinum-resistant ovarian epithelial cancer, fallopian tube cancer.
AFM24 is a tetravalent, bispecific innate cell engager that binds to CD16A on innate immune cells and EGFR. It is under phase 1/2 clinical development in combination with atezolizumab for the treatment of EGFR-Wildtype Non-Small Cell Lung Cancer.
VIP152 (enitociclib) is a highly selective CDK9 inhibitor that prevents activation of RNA polymerase II, resulting in reduction of known oncogenes MYC and MCL1. It is currently in Phase 1/2 trials combination with venetoclax and prednisone for the treatment of Lymphoma.
IMA402 is the first next-generation, half-life extended TCR Bispecific targeting PRAME in HLA-A*02:01-positive patients with PRAME-expressing recurrent and/or refractory solid tumors.
TK-8001 is a CD8 TCR-T specific for the Melanoma-associated Antigen Gene-A1, or MAGE-A1. TK-8001 TCR-T cells currently being investigated in the IMAG1NE Phase 1/2 clinical trial for MAGE-A1 positive solid tumors.
MDG1011 is a TCR-T immunotherapy directed against the tumor antigen PRAME and was manufactured to be administered in a single intravenous dose to patients suffering from relapsed or refractory acute myeloid leukemia, myelodysplastic syndrome or multiple myeloma.
The financing will support the continued, promising clinical development of its lead candidate, visugromab, a humanized monoclonal antibody engineered to neutralize the tumor-produced Growth Differentiation Factor-15 (GDF-15).
CPI-0209 (tulmimetostat) is an oral, investigational next-generation selective dual inhibitor of EZH2 and EZH1 designed to improve on first generation EZH2 inhibitors via increased potency, longer residence time on target and a longer half-life.
AFM24 is a tetravalent, bispecific innate cell engager (ICE®) that activates the innate immune system by binding to CD16A on innate immune cells and EGFR, a protein widely expressed on solid tumors, to kill cancer cells.