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    [{"orgOrder":0,"company":"Kintai Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"KTX-0200","moa":"Undisclosed","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Kintai Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Kintai Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Kintai Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"9 Meters Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Antibody","year":"2023","type":"Inapplicable","leadProduct":"NM-136","moa":"GIP","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"9 Meters Biopharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Injection","sponsorNew":"9 Meters Biopharma \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"9 Meters Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"9 Meters Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Antibody","year":"2022","type":"Inapplicable","leadProduct":"NM-136","moa":"GIP","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"9 Meters Biopharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Injection","sponsorNew":"9 Meters Biopharma \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"9 Meters Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Kexing Biopharm","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"CHINA","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"GB18","moa":"GDF-15","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Kexing Biopharm","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Kexing Biopharm \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Kexing Biopharm \/ Inapplicable"},{"orgOrder":0,"company":"TransThera Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"CHINA","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"TT-02332","moa":"Undisclosed","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"TransThera Biosciences","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"TransThera Biosciences \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"TransThera Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Biolexis Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"BLX 0871","moa":"Undisclosed","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Biolexis Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Biolexis Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Biolexis Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Fractyl Health","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Cell and Gene therapy","year":"2024","type":"Inapplicable","leadProduct":"RJVA-001","moa":"Undisclosed","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Fractyl Health","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Fractyl Health \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Fractyl Health \/ Inapplicable"},{"orgOrder":0,"company":"Fractyl Health","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"RJVA-001","moa":"Undisclosed","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Fractyl Health","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Fractyl Health \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Fractyl Health \/ Inapplicable"},{"orgOrder":0,"company":"Fractyl Health","sponsor":"Nantahala Capital","pharmaFlowCategory":"D","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Public Offering","leadProduct":"RJVA-001","moa":"GLP-1 receptor","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Fractyl Health","amount2":0.02,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0.02,"dosageForm":"Undisclosed","sponsorNew":"Fractyl Health \/ Nantahala Capital","highestDevelopmentStatusID":"5","companyTruncated":"Fractyl Health \/ Nantahala Capital"},{"orgOrder":0,"company":"Fractyl Health","sponsor":"Nantahala Capital","pharmaFlowCategory":"D","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Public Offering","leadProduct":"RJVA-001","moa":"GLP-1 receptor","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Fractyl Health","amount2":0.02,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0.02,"dosageForm":"Undisclosed","sponsorNew":"Fractyl Health \/ Nantahala Capital","highestDevelopmentStatusID":"5","companyTruncated":"Fractyl Health \/ Nantahala Capital"},{"orgOrder":0,"company":"Superluminal Medicines","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Undisclosed","moa":"MC4 receptor","graph1":"Nutrition and Weight Loss","graph2":"IND Enabling","graph3":"Superluminal Medicines","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Superluminal Medicines \/ Undisclosed","highestDevelopmentStatusID":"5","companyTruncated":"Superluminal Medicines \/ Undisclosed"}]

    Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                            01

                            Fractyl Health

                            U.S.A arrow
                            Boulder Peptide
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                            Fractyl Health

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                            Lead Product(s) : RJVA-001

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Nantahala Capital

                            Deal Size : $23.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Fractyl Health Announces Closing of $23 Million Underwritten Public Offering

                            Details : Fractyl intends to use net proceeds to support development of its Revita and Rejuva platforms, including RJVA-001, designed to express glucagon-like peptide-1 (GLP-1) locally in pancreatic beta cells.

                            Product Name : RJVA-001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            August 07, 2025

                            Lead Product(s) : RJVA-001

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Nantahala Capital

                            Deal Size : $23.0 million

                            Deal Type : Public Offering

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                            02

                            Fractyl Health

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                            Boulder Peptide
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                            Fractyl Health

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                            Boulder Peptide
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                            Lead Product(s) : RJVA-001

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Nantahala Capital

                            Deal Size : $20.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Fractyl Health Announces Pricing of $20 Million Underwritten Public Offering

                            Details : Fractyl intends to use net proceeds to support development of its Revita and Rejuva platforms, including RJVA-001, designed to express glucagon-like peptide-1 (GLP-1) locally in pancreatic beta cells.

                            Product Name : RJVA-001

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            August 06, 2025

                            Lead Product(s) : RJVA-001

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Nantahala Capital

                            Deal Size : $20.0 million

                            Deal Type : Public Offering

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                            03

                            Superluminal Medicines

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                            Boulder Peptide
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                            Superluminal Medicines

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                            Boulder Peptide
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Superluminal Advances Selective MC4R Agonist To IND Studies For Obesity

                            Details : Superluminal's compound is an orally administered, highly selective, biased MC4R agonist initially targeting rare genetic forms of obesity and hypothalamic obesity.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 22, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            MBX Biosciences

                            U.S.A arrow
                            Boulder Peptide
                            Not Confirmed

                            MBX Biosciences

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                            Boulder Peptide
                            Not Confirmed
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                            Lead Product(s) : MBX 4291

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            MBX Biosciences Submits IND for MBX 4291 to Treat Obesity with GLP1/GIP Co-Agonist

                            Details : MBX 4291 is a long-acting GLP1/GIP Receptor co-agonist prodrug, which is currently being evaluated for the treatment of obesity.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            June 16, 2025

                            Lead Product(s) : MBX 4291

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Kexing Biopharm

                            China arrow
                            Boulder Peptide
                            Not Confirmed

                            Kexing Biopharm

                            China arrow
                            Boulder Peptide
                            Not Confirmed
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                            Lead Product(s) : GB18

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kexing Biopharm's GB18 project received clearance of IND application from NMPA and FDA

                            Details : GB18 is an innovative biologic product and a nanobody targeting GDF-15 developed for the treatment of cancer cachexia.

                            Product Name : Undisclosed

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            May 28, 2025

                            Lead Product(s) : GB18

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Zealand Pharma

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                            Boulder Peptide
                            Not Confirmed

                            Zealand Pharma

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                            Boulder Peptide
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                            Lead Product(s) : Petrelintide,CT-388

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $5,300.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Roche & Zealand Partner to Develop Petrelintide for Obesity & Overweight Therapy

                            Details : The two companies will collaborate to co-develop and co-commercialise ZP8396 (petrelintide) in combination with CT-388 for the treatment of obesity.

                            Product Name : Undisclosed

                            Product Type : Peptide

                            Upfront Cash : $1,650.0 million

                            March 12, 2025

                            Lead Product(s) : Petrelintide,CT-388

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $5,300.0 million

                            Deal Type : Collaboration

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                            07

                            Arrowhead Pharmaceuticals

                            U.S.A arrow
                            Boulder Peptide
                            Not Confirmed

                            Arrowhead Pharmaceuticals

                            U.S.A arrow
                            Boulder Peptide
                            Not Confirmed
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                            Lead Product(s) : ARO-ALK7

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Arrowhead Pharmaceuticals Presents Preclinical Data on ARO-ALK7 for Treatment of Obesity

                            Details : ARO-ALK7 is the first RNAi-based therapy to directly target a gene expressed in adipose tissue. It is being evaluated for the treatment of obesity.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            February 25, 2025

                            Lead Product(s) : ARO-ALK7

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Arrowhead Pharmaceuticals

                            U.S.A arrow
                            Boulder Peptide
                            Not Confirmed

                            Arrowhead Pharmaceuticals

                            U.S.A arrow
                            Boulder Peptide
                            Not Confirmed
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                            Lead Product(s) : ARO-ALK7

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Arrowhead Seeks Approval for ARO-ALK7 Phase 1/2a Trial in Obesity Treatment

                            Details : ARO-ALK7 is an ACVR1C gene expression silencer, in adipose tissue, which led to reduced body weight and fat mass with preservation of lean muscle, in obese patients

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            December 03, 2024

                            Lead Product(s) : ARO-ALK7

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Biolexis Therapeutics

                            U.S.A arrow
                            Boulder Peptide
                            Not Confirmed

                            Biolexis Therapeutics

                            U.S.A arrow
                            Boulder Peptide
                            Not Confirmed
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                            Lead Product(s) : BLX 0871

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Biolexis Advances AMPK Agonists for Weight Loss in Preclinical Development

                            Details : BLX 0871 is an AMPK activator, which is being evaluated in the early-stage clinical trial studies for the treatment of obesity and Type 2 diabetes.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 29, 2024

                            Lead Product(s) : BLX 0871

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Resalis Therapeutics

                            Italy arrow
                            Boulder Peptide
                            Not Confirmed

                            Resalis Therapeutics

                            Italy arrow
                            Boulder Peptide
                            Not Confirmed
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                            Lead Product(s) : RES-010

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : IND Enabling

                            Sponsor : Sanofi

                            Deal Size : Undisclosed

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Resalis Therapeutics Gains Strategic Equity Investment from Sanofi

                            Details : The company intends to use the proceeds to accelerate the development of its lead investigational candidate, RES-010 for the treatment of obesity.

                            Product Name : Undisclosed

                            Product Type : Other Large Molecule

                            Upfront Cash : Undisclosed

                            October 28, 2024

                            Lead Product(s) : RES-010

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : IND Enabling

                            Sponsor : Sanofi

                            Deal Size : Undisclosed

                            Deal Type : Financing

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